Lack of association between childhood common acute lymphoblastic leukaemia and an HLA-C locus dimorphism influencing the specificity of natural killer cells.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91993
Title:
Lack of association between childhood common acute lymphoblastic leukaemia and an HLA-C locus dimorphism influencing the specificity of natural killer cells.
Authors:
Ghodsi, K; Taylor, G M; Gokhale, D A; Dearden, S; Stevens, R F; Birch, Jillian M; Fergusson, W D; Eden, Tim O B; Ollier, W
Abstract:
Previous serological studies documenting an association between acute lymphoblastic leukaemia (ALL) and HLA-Cw antigens suggested that the HLA-C locus might influence susceptibility to ALL. However, associations with more than one Cw antigen suggest that polymorphic variants shared by more than Cw allele could be involved. Recent studies have shown that the HLA-C locus encodes two ligands (NK1 and NK2) recognized by receptors on natural killer (NK) cells. HLA-Cw alleles encoding these ligands are dimorphic, dependent on whether they encode one or other NK ligand. To determine whether susceptibility to the common (CD10+) form of childhood ALL (c-ALL) is associated with NK1 or NK2, we carried out a molecular analysis of 94 childhood c-ALL patients and 136 infant controls. We found no difference in the frequency of NK1 and NK2 alleles, phenotypes or genotypes between the patients and controls, suggesting that this does not explain the role of the HLA-C locus in susceptibility to childhood c-ALL.
Affiliation:
Immunogenetics Laboratory, St Mary's Hospital, Manchester.
Citation:
Lack of association between childhood common acute lymphoblastic leukaemia and an HLA-C locus dimorphism influencing the specificity of natural killer cells. 1998, 102 (5):1279-83 Br. J. Haematol.
Journal:
British Journal of Haematology
Issue Date:
Sep-1998
URI:
http://hdl.handle.net/10541/91993
DOI:
10.1046/j.1365-2141.1998.00919.x
PubMed ID:
9753057
Type:
Article
Language:
en
ISSN:
0007-1048
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGhodsi, Ken
dc.contributor.authorTaylor, G Men
dc.contributor.authorGokhale, D Aen
dc.contributor.authorDearden, Sen
dc.contributor.authorStevens, R Fen
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorFergusson, W Den
dc.contributor.authorEden, Tim O Ben
dc.contributor.authorOllier, Wen
dc.date.accessioned2010-02-12T12:29:08Z-
dc.date.available2010-02-12T12:29:08Z-
dc.date.issued1998-09-
dc.identifier.citationLack of association between childhood common acute lymphoblastic leukaemia and an HLA-C locus dimorphism influencing the specificity of natural killer cells. 1998, 102 (5):1279-83 Br. J. Haematol.en
dc.identifier.issn0007-1048-
dc.identifier.pmid9753057-
dc.identifier.doi10.1046/j.1365-2141.1998.00919.x-
dc.identifier.urihttp://hdl.handle.net/10541/91993-
dc.description.abstractPrevious serological studies documenting an association between acute lymphoblastic leukaemia (ALL) and HLA-Cw antigens suggested that the HLA-C locus might influence susceptibility to ALL. However, associations with more than one Cw antigen suggest that polymorphic variants shared by more than Cw allele could be involved. Recent studies have shown that the HLA-C locus encodes two ligands (NK1 and NK2) recognized by receptors on natural killer (NK) cells. HLA-Cw alleles encoding these ligands are dimorphic, dependent on whether they encode one or other NK ligand. To determine whether susceptibility to the common (CD10+) form of childhood ALL (c-ALL) is associated with NK1 or NK2, we carried out a molecular analysis of 94 childhood c-ALL patients and 136 infant controls. We found no difference in the frequency of NK1 and NK2 alleles, phenotypes or genotypes between the patients and controls, suggesting that this does not explain the role of the HLA-C locus in susceptibility to childhood c-ALL.en
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshFemale-
dc.subject.meshGene Frequency-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHLA-C Antigens-
dc.subject.meshHeterozygote-
dc.subject.meshHomozygote-
dc.subject.meshHumans-
dc.subject.meshKiller Cells, Natural-
dc.subject.meshMale-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.titleLack of association between childhood common acute lymphoblastic leukaemia and an HLA-C locus dimorphism influencing the specificity of natural killer cells.en
dc.typeArticleen
dc.contributor.departmentImmunogenetics Laboratory, St Mary's Hospital, Manchester.en
dc.identifier.journalBritish Journal of Haematologyen

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