Bone density in long term users of depot medroxyprogesterone acetate.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91974
Title:
Bone density in long term users of depot medroxyprogesterone acetate.
Authors:
Gbolade, B; Ellis, S; Murby, Brian; Randall, S; Kirkman, R
Abstract:
OBJECTIVE: To identify any adverse effect on bone density in long term users of depot medroxyprogesterone acetate (DMPA) for contraception. DESIGN: Cross-sectional measurement of bone density in users with amenorrhoea of more than one year or any woman using DMPA for more than five years. SETTING: Community Family Planning Clinics in Portsmouth and Manchester. POPULATION: One hundred and eighty-five women aged 17-52 years (mean 33.3 years) who had used DMPA for between 1 and 16 years and were attending the clinics for further injections, between August 1994 and August 1996. METHODS: Dual energy X-ray measurement of bone density of femoral neck and lumbar spine, and venous blood sample taken just prior to the next injection of DMPA. MAIN OUTCOME MEASURES: Bone density of femoral neck and lumbar spine and serum oestradiol in relationship to years of DMPA use and duration of amenorrhoea. RESULTS: Most women (n=153) had serum oestradiol levels < 150 pmol/l. Despite this, the mean bone density of the lumbar spine compared with the population mean for women aged 20-59 years gave a Z score (95% CI) of -0.332 (-0.510 to -0.154). There was no significant difference in the mean density of the femoral neck from the normal population mean. CONCLUSION: Despite amenorrhoea and low serum oestradiol, this sample of long term DMPA users had bone density only minimally below the normal population mean. We therefore found no clinically important adverse effect on bone density and therefore no reason to recommend bone conserving measures, such as add-back oestrogen.
Affiliation:
Palatine Centre, University of Manchester, UK.
Citation:
Bone density in long term users of depot medroxyprogesterone acetate. 1998, 105 (7):790-4 Br J Obstet Gynaecol
Journal:
British Journal of Obstetrics and Gynaecology
Issue Date:
Jul-1998
URI:
http://hdl.handle.net/10541/91974
PubMed ID:
9692421
Type:
Article
Language:
en
ISSN:
0306-5456
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGbolade, Ben
dc.contributor.authorEllis, Sen
dc.contributor.authorMurby, Brianen
dc.contributor.authorRandall, Sen
dc.contributor.authorKirkman, Ren
dc.date.accessioned2010-02-12T12:27:41Z-
dc.date.available2010-02-12T12:27:41Z-
dc.date.issued1998-07-
dc.identifier.citationBone density in long term users of depot medroxyprogesterone acetate. 1998, 105 (7):790-4 Br J Obstet Gynaecolen
dc.identifier.issn0306-5456-
dc.identifier.pmid9692421-
dc.identifier.urihttp://hdl.handle.net/10541/91974-
dc.description.abstractOBJECTIVE: To identify any adverse effect on bone density in long term users of depot medroxyprogesterone acetate (DMPA) for contraception. DESIGN: Cross-sectional measurement of bone density in users with amenorrhoea of more than one year or any woman using DMPA for more than five years. SETTING: Community Family Planning Clinics in Portsmouth and Manchester. POPULATION: One hundred and eighty-five women aged 17-52 years (mean 33.3 years) who had used DMPA for between 1 and 16 years and were attending the clinics for further injections, between August 1994 and August 1996. METHODS: Dual energy X-ray measurement of bone density of femoral neck and lumbar spine, and venous blood sample taken just prior to the next injection of DMPA. MAIN OUTCOME MEASURES: Bone density of femoral neck and lumbar spine and serum oestradiol in relationship to years of DMPA use and duration of amenorrhoea. RESULTS: Most women (n=153) had serum oestradiol levels < 150 pmol/l. Despite this, the mean bone density of the lumbar spine compared with the population mean for women aged 20-59 years gave a Z score (95% CI) of -0.332 (-0.510 to -0.154). There was no significant difference in the mean density of the femoral neck from the normal population mean. CONCLUSION: Despite amenorrhoea and low serum oestradiol, this sample of long term DMPA users had bone density only minimally below the normal population mean. We therefore found no clinically important adverse effect on bone density and therefore no reason to recommend bone conserving measures, such as add-back oestrogen.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshBone Density-
dc.subject.meshContraceptive Agents, Female-
dc.subject.meshCross-Sectional Studies-
dc.subject.meshFemale-
dc.subject.meshFemur Neck-
dc.subject.meshHumans-
dc.subject.meshLumbar Vertebrae-
dc.subject.meshMedroxyprogesterone Acetate-
dc.subject.meshMiddle Aged-
dc.subject.meshTime Factors-
dc.titleBone density in long term users of depot medroxyprogesterone acetate.en
dc.typeArticleen
dc.contributor.departmentPalatine Centre, University of Manchester, UK.en
dc.identifier.journalBritish Journal of Obstetrics and Gynaecologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.