A comparative analysis of lipid-complexed and liposomal amphotericin B preparations in haematological oncology.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91949
Title:
A comparative analysis of lipid-complexed and liposomal amphotericin B preparations in haematological oncology.
Authors:
Clark, A D; McKendrick, S; Tansey, P J; Franklin, Ian M; Chopra, Rajesh
Abstract:
No comparative clinical information on the properties of lipid-associated amphotericin preparations is presently available. In this single-centre retrospective analysis over a 5-year period the indications, efficacy and toxicity of true liposomal amphotericin (AmBisome) were compared with a lipid complexed preparation (Abelcet). In a novel approach APACHE III scores were used in addition to neutrophil counts, disease status and additional immunosuppression to accurately assess the severity of illness in both groups and enable valid comparison. Overall, AmBisome at a median dose of 1.9 mg/kg/d was found to have similar clinical outcome to Abelcet at a median dose of 4.8 mg/kg/d. Nephrotoxicity and electrolyte abnormalities were similar in both groups. Rigors and febrile episodes were more common with Abelcet. Prospective randomized comparative trials are required to clarify the optimum dosages and therapeutic and economic issues associated with these agents.
Affiliation:
Glasgow Royal Infirmary.
Citation:
A comparative analysis of lipid-complexed and liposomal amphotericin B preparations in haematological oncology. 1998, 103 (1):198-204 Br. J. Haematol.
Journal:
British Journal of Haematology
Issue Date:
Oct-1998
URI:
http://hdl.handle.net/10541/91949
DOI:
10.1046/j.1365-2141.1998.00934.x
PubMed ID:
9792308
Type:
Article
Language:
en
ISSN:
0007-1048
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorClark, A Den
dc.contributor.authorMcKendrick, Sen
dc.contributor.authorTansey, P Jen
dc.contributor.authorFranklin, Ian Men
dc.contributor.authorChopra, Rajeshen
dc.date.accessioned2010-02-12T11:20:30Z-
dc.date.available2010-02-12T11:20:30Z-
dc.date.issued1998-10-
dc.identifier.citationA comparative analysis of lipid-complexed and liposomal amphotericin B preparations in haematological oncology. 1998, 103 (1):198-204 Br. J. Haematol.en
dc.identifier.issn0007-1048-
dc.identifier.pmid9792308-
dc.identifier.doi10.1046/j.1365-2141.1998.00934.x-
dc.identifier.urihttp://hdl.handle.net/10541/91949-
dc.description.abstractNo comparative clinical information on the properties of lipid-associated amphotericin preparations is presently available. In this single-centre retrospective analysis over a 5-year period the indications, efficacy and toxicity of true liposomal amphotericin (AmBisome) were compared with a lipid complexed preparation (Abelcet). In a novel approach APACHE III scores were used in addition to neutrophil counts, disease status and additional immunosuppression to accurately assess the severity of illness in both groups and enable valid comparison. Overall, AmBisome at a median dose of 1.9 mg/kg/d was found to have similar clinical outcome to Abelcet at a median dose of 4.8 mg/kg/d. Nephrotoxicity and electrolyte abnormalities were similar in both groups. Rigors and febrile episodes were more common with Abelcet. Prospective randomized comparative trials are required to clarify the optimum dosages and therapeutic and economic issues associated with these agents.en
dc.language.isoenen
dc.subjectHaematologic Canceren
dc.subject.meshAdult-
dc.subject.meshAmphotericin B-
dc.subject.meshAntifungal Agents-
dc.subject.meshCreatinine-
dc.subject.meshDrug Combinations-
dc.subject.meshFemale-
dc.subject.meshHematologic Neoplasms-
dc.subject.meshHumans-
dc.subject.meshImmune Tolerance-
dc.subject.meshLeukocyte Count-
dc.subject.meshMale-
dc.subject.meshMycoses-
dc.subject.meshNeutrophils-
dc.subject.meshOpportunistic Infections-
dc.subject.meshPhosphatidylcholines-
dc.subject.meshPhosphatidylglycerols-
dc.subject.meshRetrospective Studies-
dc.subject.meshTreatment Outcome-
dc.subject.meshWater-Electrolyte Imbalance-
dc.titleA comparative analysis of lipid-complexed and liposomal amphotericin B preparations in haematological oncology.en
dc.typeArticleen
dc.contributor.departmentGlasgow Royal Infirmary.en
dc.identifier.journalBritish Journal of Haematologyen

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