The effect of diclofenac (voltarol) and pethidine on ureteric peristalsis and the isotope renogram.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91930
Title:
The effect of diclofenac (voltarol) and pethidine on ureteric peristalsis and the isotope renogram.
Authors:
Brough, R J; Lancashire, M J; Prince, Jennie R; Rose, Marge R; Prescott, M C; Payne, S R; Testa, H J
Abstract:
Diclofenac (a non-steroidal anti-inflammatory drug) and pethidine (a synthetic opiate) are the two analgesics most commonly used to relieve the pain of ureteric colic. Fast frame renography is a non-invasive means of imaging ureteric peristalsis and renal drainage. The aim of this study was to determine the effects of each of these drugs on the drainage pattern of the upper tracts. Twelve normal male volunteers were studied. All underwent a standard fast frame renogram using 75 MBq of technetium-99m-mercaptoacetyltriglycine, and were then administered either 100 mg pethidine or 75 mg diclofenac by intramuscular injection. Fast frame renography was then repeated. Peristalsis was determined from the condensed image of each ureter and the renogram curves were analysed to obtain standard parameters and deconvolution analysis. Diclofenac caused a profound disruption to both ureteric peristalsis and the renogram curve. This effect was not seen after the administration of pethidine. Deconvolution analysis suggests the effects of diclofenac are mediated via a direct effect on drainage rather than by any alteration of blood flow to the kidney. This study suggests that pethidine is the analgesic of choice prior to renography and that inferences about alterations of drainage in the presence of diclofenac should be interpreted with care.
Affiliation:
Department of Urology, Withington Hospital, Manchester, UK.
Citation:
The effect of diclofenac (voltarol) and pethidine on ureteric peristalsis and the isotope renogram. 1998, 25 (11):1520-3 Eur J Nucl Med
Journal:
European Journal of Nuclear Medicine
Issue Date:
Nov-1998
URI:
http://hdl.handle.net/10541/91930
DOI:
10.1007/s002590050330
PubMed ID:
9799348
Type:
Article
Language:
en
ISSN:
0340-6997
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBrough, R Jen
dc.contributor.authorLancashire, M Jen
dc.contributor.authorPrince, Jennie Ren
dc.contributor.authorRose, Marge Ren
dc.contributor.authorPrescott, M Cen
dc.contributor.authorPayne, S Ren
dc.contributor.authorTesta, H Jen
dc.date.accessioned2010-02-12T12:21:40Z-
dc.date.available2010-02-12T12:21:40Z-
dc.date.issued1998-11-
dc.identifier.citationThe effect of diclofenac (voltarol) and pethidine on ureteric peristalsis and the isotope renogram. 1998, 25 (11):1520-3 Eur J Nucl Meden
dc.identifier.issn0340-6997-
dc.identifier.pmid9799348-
dc.identifier.doi10.1007/s002590050330-
dc.identifier.urihttp://hdl.handle.net/10541/91930-
dc.description.abstractDiclofenac (a non-steroidal anti-inflammatory drug) and pethidine (a synthetic opiate) are the two analgesics most commonly used to relieve the pain of ureteric colic. Fast frame renography is a non-invasive means of imaging ureteric peristalsis and renal drainage. The aim of this study was to determine the effects of each of these drugs on the drainage pattern of the upper tracts. Twelve normal male volunteers were studied. All underwent a standard fast frame renogram using 75 MBq of technetium-99m-mercaptoacetyltriglycine, and were then administered either 100 mg pethidine or 75 mg diclofenac by intramuscular injection. Fast frame renography was then repeated. Peristalsis was determined from the condensed image of each ureter and the renogram curves were analysed to obtain standard parameters and deconvolution analysis. Diclofenac caused a profound disruption to both ureteric peristalsis and the renogram curve. This effect was not seen after the administration of pethidine. Deconvolution analysis suggests the effects of diclofenac are mediated via a direct effect on drainage rather than by any alteration of blood flow to the kidney. This study suggests that pethidine is the analgesic of choice prior to renography and that inferences about alterations of drainage in the presence of diclofenac should be interpreted with care.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAnalgesics, Opioid-
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal-
dc.subject.meshDiclofenac-
dc.subject.meshHumans-
dc.subject.meshImage Processing, Computer-Assisted-
dc.subject.meshMale-
dc.subject.meshMeperidine-
dc.subject.meshRadioisotope Renography-
dc.subject.meshReference Values-
dc.subject.meshUreter-
dc.titleThe effect of diclofenac (voltarol) and pethidine on ureteric peristalsis and the isotope renogram.en
dc.typeArticleen
dc.contributor.departmentDepartment of Urology, Withington Hospital, Manchester, UK.en
dc.identifier.journalEuropean Journal of Nuclear Medicineen

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