Sclerosing epithelioid fibrosarcoma: a study of five cases emphasizing diagnostic criteria.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91892
Title:
Sclerosing epithelioid fibrosarcoma: a study of five cases emphasizing diagnostic criteria.
Authors:
Eyden, Brian P; Manson, C M; Banerjee, Saumitra S; Roberts, I S; Harris, Martin
Abstract:
AIMS: To study the clinical and histopathological features of sclerosing epithelioid fibrosarcoma, and to define diagnostic criteria for this uncommon soft-tissue tumour. METHODS AND RESULTS: Standard histological, immunohistochemical and ultrastructural techniques were applied to five tumours from head and neck, chest wall and groin. Tumours consisted of groups of monomorphic rounded/epithelioid cells surrounded by a prominent collagenous stroma. Tumour cells showed positive vimentin staining but were negative for other markers. They contained prominent rough endoplasmic reticulum and a large Golgi apparatus which in one case was producing collagen secretion granules, an ultrastructural marker for collagen production. Three patients had medium to long-term survival (3-7 years). Of these, one was disease-free for 3 years, and two experienced multiple recurrences: one of the latter died of metastatic disease. CONCLUSION: Criteria for diagnosing this uncommon tumour include: small to medium cell size, clear or pale cytoplasm, cellular arrangement in cords and strands, dense collagenous stroma; vimentin staining; rough endoplasmic reticulum and a Golgi apparatus producing, in well preserved examples, collagen secretion granules. The paper emphasizes the value of electron microscopy, supporting an appropriate histological picture and immunophenotype, in identifying these relatively low-grade sarcomas.
Affiliation:
Christie Hospital NHS Trust, Manchester, UK.
Citation:
Sclerosing epithelioid fibrosarcoma: a study of five cases emphasizing diagnostic criteria. 1998, 33 (4):354-60 Histopathology
Journal:
Histopathology
Issue Date:
Oct-1998
URI:
http://hdl.handle.net/10541/91892
PubMed ID:
9822926
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorManson, C Men
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorRoberts, I Sen
dc.contributor.authorHarris, Martinen
dc.date.accessioned2010-02-11T16:59:53Z-
dc.date.available2010-02-11T16:59:53Z-
dc.date.issued1998-10-
dc.identifier.citationSclerosing epithelioid fibrosarcoma: a study of five cases emphasizing diagnostic criteria. 1998, 33 (4):354-60 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid9822926-
dc.identifier.urihttp://hdl.handle.net/10541/91892-
dc.description.abstractAIMS: To study the clinical and histopathological features of sclerosing epithelioid fibrosarcoma, and to define diagnostic criteria for this uncommon soft-tissue tumour. METHODS AND RESULTS: Standard histological, immunohistochemical and ultrastructural techniques were applied to five tumours from head and neck, chest wall and groin. Tumours consisted of groups of monomorphic rounded/epithelioid cells surrounded by a prominent collagenous stroma. Tumour cells showed positive vimentin staining but were negative for other markers. They contained prominent rough endoplasmic reticulum and a large Golgi apparatus which in one case was producing collagen secretion granules, an ultrastructural marker for collagen production. Three patients had medium to long-term survival (3-7 years). Of these, one was disease-free for 3 years, and two experienced multiple recurrences: one of the latter died of metastatic disease. CONCLUSION: Criteria for diagnosing this uncommon tumour include: small to medium cell size, clear or pale cytoplasm, cellular arrangement in cords and strands, dense collagenous stroma; vimentin staining; rough endoplasmic reticulum and a Golgi apparatus producing, in well preserved examples, collagen secretion granules. The paper emphasizes the value of electron microscopy, supporting an appropriate histological picture and immunophenotype, in identifying these relatively low-grade sarcomas.en
dc.language.isoenen
dc.subjectSoft Tissue Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshEpithelioid Cells-
dc.subject.meshFemale-
dc.subject.meshFibrosarcoma-
dc.subject.meshHistocytochemistry-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMiddle Aged-
dc.subject.meshReticulin-
dc.subject.meshSclerosis-
dc.subject.meshSoft Tissue Neoplasms-
dc.titleSclerosing epithelioid fibrosarcoma: a study of five cases emphasizing diagnostic criteria.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen
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