Role of transforming growth factor beta3 in lymphatic metastasis in breast cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91888
Title:
Role of transforming growth factor beta3 in lymphatic metastasis in breast cancer.
Authors:
Li, Chenggang; Wang, Ji Min; Wilson, Philip B; Kumar, Patricia; Levine, Edward; Hunter, Robin D; Kumar, Shant
Abstract:
Transforming growth factor-betas (TGFbetas) play a prominent role in tumour growth and metastasis by enhancing angiogenesis and suppressing immune surveillance. Despite the increased interest in the effect of TGFbetas on tumour progression, little is known about the importance of TGFbeta3 and its receptor CD105 in breast cancer. In the present study, we measured the plasma levels of TGFbeta3, CD105-TGFbeta3 complexes and TGFbeta1 in 80 patients with untreated early-stage breast cancer using an enhanced chemiluminescence ELISA method. Of the 80 patients, 14 were histologically confirmed as having axillary lymph node metastases, while the remainder had no evidence of lymph node involvement. The results showed that levels of both TGFbeta3 and CD105-TGFbeta3 complex were significantly elevated in patients with positive lymph nodes compared to those without node metastasis. Furthermore, the levels of both TGFbeta3 and CD105-TGFbeta3 complex correlated with lymph node status. The only patient who died of the disease had very high plasma levels of TGFbeta3 and CD105-TGFbeta3 complex and positive lymph nodes; this patient developed lung metastases within 2 years of diagnosis. No significant correlation was seen between either TGFbeta3 or CD105-TGFbeta3 complex levels and tumour stage, size or histological grade. Plasma TGFbeta1 levels were not correlated with node metastasis, tumour stage, grade or size. Our data suggest that plasma levels of TGFbeta3 and CD105-TGFbeta3 complex may be of prognostic value in the early detection of metastasis of breast cancer.
Affiliation:
Department of Pathology, Medical School, University of Manchester, UK.
Citation:
Role of transforming growth factor beta3 in lymphatic metastasis in breast cancer. 1998, 79 (5):455-9 Int. J. Cancer
Journal:
International Journal of Cancer.
Issue Date:
23-Oct-1998
URI:
http://hdl.handle.net/10541/91888
DOI:
10.1002/(SICI)1097-0215(19981023)79:5<449::AID-IJC1>3.0.CO;2-0
PubMed ID:
9761112
Type:
Article
Language:
en
ISSN:
0020-7136
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Chenggangen
dc.contributor.authorWang, Ji Minen
dc.contributor.authorWilson, Philip Ben
dc.contributor.authorKumar, Patriciaen
dc.contributor.authorLevine, Edwarden
dc.contributor.authorHunter, Robin Den
dc.contributor.authorKumar, Shanten
dc.date.accessioned2010-02-11T16:41:12Z-
dc.date.available2010-02-11T16:41:12Z-
dc.date.issued1998-10-23-
dc.identifier.citationRole of transforming growth factor beta3 in lymphatic metastasis in breast cancer. 1998, 79 (5):455-9 Int. J. Canceren
dc.identifier.issn0020-7136-
dc.identifier.pmid9761112-
dc.identifier.doi10.1002/(SICI)1097-0215(19981023)79:5<449::AID-IJC1>3.0.CO;2-0-
dc.identifier.urihttp://hdl.handle.net/10541/91888-
dc.description.abstractTransforming growth factor-betas (TGFbetas) play a prominent role in tumour growth and metastasis by enhancing angiogenesis and suppressing immune surveillance. Despite the increased interest in the effect of TGFbetas on tumour progression, little is known about the importance of TGFbeta3 and its receptor CD105 in breast cancer. In the present study, we measured the plasma levels of TGFbeta3, CD105-TGFbeta3 complexes and TGFbeta1 in 80 patients with untreated early-stage breast cancer using an enhanced chemiluminescence ELISA method. Of the 80 patients, 14 were histologically confirmed as having axillary lymph node metastases, while the remainder had no evidence of lymph node involvement. The results showed that levels of both TGFbeta3 and CD105-TGFbeta3 complex were significantly elevated in patients with positive lymph nodes compared to those without node metastasis. Furthermore, the levels of both TGFbeta3 and CD105-TGFbeta3 complex correlated with lymph node status. The only patient who died of the disease had very high plasma levels of TGFbeta3 and CD105-TGFbeta3 complex and positive lymph nodes; this patient developed lung metastases within 2 years of diagnosis. No significant correlation was seen between either TGFbeta3 or CD105-TGFbeta3 complex levels and tumour stage, size or histological grade. Plasma TGFbeta1 levels were not correlated with node metastasis, tumour stage, grade or size. Our data suggest that plasma levels of TGFbeta3 and CD105-TGFbeta3 complex may be of prognostic value in the early detection of metastasis of breast cancer.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectLung Canceren
dc.subjectCancer Stagingen
dc.subject.meshAdult-
dc.subject.meshAntigens, CD-
dc.subject.meshAxilla-
dc.subject.meshBreast Neoplasms-
dc.subject.meshChemiluminescent Measurements-
dc.subject.meshEnzyme-Linked Immunosorbent Assay-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshLymph Nodes-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Staging-
dc.subject.meshPrognosis-
dc.subject.meshReceptors, Cell Surface-
dc.subject.meshTransforming Growth Factor beta-
dc.subject.meshVascular Cell Adhesion Molecule-1-
dc.titleRole of transforming growth factor beta3 in lymphatic metastasis in breast cancer.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Medical School, University of Manchester, UK.en
dc.identifier.journalInternational Journal of Cancer.en

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