Growth hormone replacement in an adult with mild growth hormone deficiency and hereditary motor and sensory neuropathy: growth hormone restores independent mobility.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91886
Title:
Growth hormone replacement in an adult with mild growth hormone deficiency and hereditary motor and sensory neuropathy: growth hormone restores independent mobility.
Authors:
Lissett, Catherine A; Toogood, Andy; Didi, Mohammed; Shalet, Stephen M
Abstract:
We present the case of an adult patient with growth hormone (GH) insufficiency and hereditary motor and sensory neuropathy type 1. Stopping GH replacement at the attainment of final height was associated with a marked reduction in power and mobility, resulting in the patient becoming wheelchair bound. GH replacement was assessed in a double-blind placebo-controlled trial. During the GH replacement arm of the trial, the patient's mobility and independence returned to previous levels. We suggest that the indications for GH replacement in adults should take account of other medical problems, in particular neuromuscular disorders, as well as the degree of GH deficiency.
Affiliation:
Department of Endocrinology, Christie Hospital, Withington, Manchester, UK.
Citation:
Growth hormone replacement in an adult with mild growth hormone deficiency and hereditary motor and sensory neuropathy: growth hormone restores independent mobility. 1998, 50 (4):232-6 Horm. Res.
Journal:
Hormone Research
Issue Date:
1998
URI:
http://hdl.handle.net/10541/91886
DOI:
10.1159/000023280
PubMed ID:
9838246
Type:
Article
Language:
en
ISSN:
0301-0163
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLissett, Catherine Aen
dc.contributor.authorToogood, Andyen
dc.contributor.authorDidi, Mohammeden
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2010-02-11T16:33:02Z-
dc.date.available2010-02-11T16:33:02Z-
dc.date.issued1998-
dc.identifier.citationGrowth hormone replacement in an adult with mild growth hormone deficiency and hereditary motor and sensory neuropathy: growth hormone restores independent mobility. 1998, 50 (4):232-6 Horm. Res.en
dc.identifier.issn0301-0163-
dc.identifier.pmid9838246-
dc.identifier.doi10.1159/000023280-
dc.identifier.urihttp://hdl.handle.net/10541/91886-
dc.description.abstractWe present the case of an adult patient with growth hormone (GH) insufficiency and hereditary motor and sensory neuropathy type 1. Stopping GH replacement at the attainment of final height was associated with a marked reduction in power and mobility, resulting in the patient becoming wheelchair bound. GH replacement was assessed in a double-blind placebo-controlled trial. During the GH replacement arm of the trial, the patient's mobility and independence returned to previous levels. We suggest that the indications for GH replacement in adults should take account of other medical problems, in particular neuromuscular disorders, as well as the degree of GH deficiency.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshCharcot-Marie-Tooth Disease-
dc.subject.meshDouble-Blind Method-
dc.subject.meshHuman Growth Hormone-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMuscle Weakness-
dc.subject.meshMuscle, Skeletal-
dc.titleGrowth hormone replacement in an adult with mild growth hormone deficiency and hereditary motor and sensory neuropathy: growth hormone restores independent mobility.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Withington, Manchester, UK.en
dc.identifier.journalHormone Researchen

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