Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91874
Title:
Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody.
Authors:
McCluggage, W G; Shanks, Jonathan H; Whiteside, C; Maxwell, P; Banerjee, Saumitra S; Biggart, J D
Abstract:
Inhibin is a peptide hormone produced by ovarian granulosa cells and testicular Sertoli cells. Ovarian granulosa cell and other sex cord-stromal tumors usually exhibit positive immunohistochemical staining with antiinhibin antibodies, and this may be valuable in differentiating these neoplasms from histologic mimics. In the present study, we investigated the immunohistochemical staining of testicular sex cord-stromal tumors using antiinhibin. Immunostaining with CAM5.2, vimentin, S-100 protein, desmin, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) also was performed because few studies have investigated in detail the immunophenotype of testicular sex cord-stromal tumors. Fifteen of 16 Leydig cell tumors exhibited strong positive staining with antiinhibin. A proportion of Leydig cell tumors also stained positively with CAM5.2 (7 of 16), vimentin (14 of 16), S-100 protein (10 of 16), desmin (2 of 16) and epithelial membrane antigen (4 of 16). Four of six testicular sex cord-stromal tumors with varying degrees of Sertoli or granulosa cell differentiation were positive with antiinhibin, as were two of three sex cord-stromal tumors that were unclassified. Some of these tumors were positive with CAM 5.2, vimentin, S-100 protein, desmin, and epithelial membrane antigen. All tumors were negative with carcinoembryonic antigen and placental alkaline phosphatase. The immunohistochemical findings show that, analogous to their ovarian counterparts, most testicular sex cord-stromal tumors are immunoreactive with antiinhibin. Immunohistochemistry using this antibody as part of a panel may be valuable in confirming a diagnosis of testicular sex cord-stromal tumor and in differentiating these neoplasms from others that may mimic them.
Affiliation:
Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland.
Citation:
Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. 1998, 22 (5):615-9 Am. J. Surg. Pathol.
Journal:
American Journal of Surgical Pathology
Issue Date:
May-1998
URI:
http://hdl.handle.net/10541/91874
PubMed ID:
9591732
Type:
Article
Language:
en
ISSN:
0147-5185
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMcCluggage, W Gen
dc.contributor.authorShanks, Jonathan Hen
dc.contributor.authorWhiteside, Cen
dc.contributor.authorMaxwell, Pen
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorBiggart, J Den
dc.date.accessioned2010-02-11T15:51:03Z-
dc.date.available2010-02-11T15:51:03Z-
dc.date.issued1998-05-
dc.identifier.citationImmunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. 1998, 22 (5):615-9 Am. J. Surg. Pathol.en
dc.identifier.issn0147-5185-
dc.identifier.pmid9591732-
dc.identifier.urihttp://hdl.handle.net/10541/91874-
dc.description.abstractInhibin is a peptide hormone produced by ovarian granulosa cells and testicular Sertoli cells. Ovarian granulosa cell and other sex cord-stromal tumors usually exhibit positive immunohistochemical staining with antiinhibin antibodies, and this may be valuable in differentiating these neoplasms from histologic mimics. In the present study, we investigated the immunohistochemical staining of testicular sex cord-stromal tumors using antiinhibin. Immunostaining with CAM5.2, vimentin, S-100 protein, desmin, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) also was performed because few studies have investigated in detail the immunophenotype of testicular sex cord-stromal tumors. Fifteen of 16 Leydig cell tumors exhibited strong positive staining with antiinhibin. A proportion of Leydig cell tumors also stained positively with CAM5.2 (7 of 16), vimentin (14 of 16), S-100 protein (10 of 16), desmin (2 of 16) and epithelial membrane antigen (4 of 16). Four of six testicular sex cord-stromal tumors with varying degrees of Sertoli or granulosa cell differentiation were positive with antiinhibin, as were two of three sex cord-stromal tumors that were unclassified. Some of these tumors were positive with CAM 5.2, vimentin, S-100 protein, desmin, and epithelial membrane antigen. All tumors were negative with carcinoembryonic antigen and placental alkaline phosphatase. The immunohistochemical findings show that, analogous to their ovarian counterparts, most testicular sex cord-stromal tumors are immunoreactive with antiinhibin. Immunohistochemistry using this antibody as part of a panel may be valuable in confirming a diagnosis of testicular sex cord-stromal tumor and in differentiating these neoplasms from others that may mimic them.en
dc.language.isoenen
dc.subjectLeydig Cell Tumouren
dc.subjectSertoli Cell Tumouren
dc.subjectTesticular Canceren
dc.subjectSex Cord-Gonadal Stromal Tumoursen
dc.subjectBiological Tumour Markersen
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshInhibins-
dc.subject.meshLeydig Cell Tumor-
dc.subject.meshMale-
dc.subject.meshSertoli Cell Tumor-
dc.subject.meshSex Cord-Gonadal Stromal Tumors-
dc.subject.meshTesticular Neoplasms-
dc.subject.meshTumor Markers, Biological-
dc.titleImmunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland.en
dc.identifier.journalAmerican Journal of Surgical Pathologyen
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