Recommendations on the use of colony-stimulating factors in children: conclusions of a European panel.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91813
Title:
Recommendations on the use of colony-stimulating factors in children: conclusions of a European panel.
Authors:
Schaison, G; Eden, Tim O B; Henze, G; Kamps, W A; Locatelli, F; Ninane, J; Ortega, J; Riikonen, P; Wagner, H P
Abstract:
During 1996 and 1997 a panel of European haematologists, oncologists, and neonatologists developed specific paediatric guidelines for the use of colony stimulating factors based on published literature and the clinical experience of these specialists within each of 13 countries. Well established indications for use comprise intervention in patients with life-threatening infection, adjunctive therapy post autologous bone marrow transplantation (BMT), mobilization of peripheral blood progenitor cells for autologous BMT, patients with acquired aplastic anaemia on anti-lymphocyte globulin and cyclosporin regimen, and severe congenital neutropenia. Less clear indications include primary prophylaxis to support dose intensification in children with high risk/advanced malignancies, secondary prophylaxis to prevent neutropenia in patients with a history of severe neutropenia, support therapy in cases of poor marrow function following BMT and for deteriorating marrow function following successful BMT, in neonatal sepsis and non infectious neonatal neutropenia, in drug induced neutropenia and in HIV-positive patients. Treatment is generally well tolerated and granulocyte colony stimulating factor appears better tolerated than granulocyte and macrophage colony stimulating factor. Economically colony stimulating factors have not been shown to induce excessive costs for a given patient. CONCLUSION: In general the adult guidelines are applicable to children but additional considerations (aggressive or very progressive childhood neoplasms, specific indications, neonatal use, congenital disorders) must be taken into account.
Affiliation:
Hospital Saint-Louis, Paris, France.
Citation:
Recommendations on the use of colony-stimulating factors in children: conclusions of a European panel. 1998, 157 (12):955-66 Eur. J. Pediatr.
Journal:
European Journal of Pediatrics
Issue Date:
Dec-1998
URI:
http://hdl.handle.net/10541/91813
DOI:
10.1007/s004310050978
PubMed ID:
9877032
Type:
Article
Language:
en
ISSN:
0340-6199
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSchaison, Gen
dc.contributor.authorEden, Tim O Ben
dc.contributor.authorHenze, Gen
dc.contributor.authorKamps, W Aen
dc.contributor.authorLocatelli, Fen
dc.contributor.authorNinane, Jen
dc.contributor.authorOrtega, Jen
dc.contributor.authorRiikonen, Pen
dc.contributor.authorWagner, H Pen
dc.date.accessioned2010-02-10T17:00:08Z-
dc.date.available2010-02-10T17:00:08Z-
dc.date.issued1998-12-
dc.identifier.citationRecommendations on the use of colony-stimulating factors in children: conclusions of a European panel. 1998, 157 (12):955-66 Eur. J. Pediatr.en
dc.identifier.issn0340-6199-
dc.identifier.pmid9877032-
dc.identifier.doi10.1007/s004310050978-
dc.identifier.urihttp://hdl.handle.net/10541/91813-
dc.description.abstractDuring 1996 and 1997 a panel of European haematologists, oncologists, and neonatologists developed specific paediatric guidelines for the use of colony stimulating factors based on published literature and the clinical experience of these specialists within each of 13 countries. Well established indications for use comprise intervention in patients with life-threatening infection, adjunctive therapy post autologous bone marrow transplantation (BMT), mobilization of peripheral blood progenitor cells for autologous BMT, patients with acquired aplastic anaemia on anti-lymphocyte globulin and cyclosporin regimen, and severe congenital neutropenia. Less clear indications include primary prophylaxis to support dose intensification in children with high risk/advanced malignancies, secondary prophylaxis to prevent neutropenia in patients with a history of severe neutropenia, support therapy in cases of poor marrow function following BMT and for deteriorating marrow function following successful BMT, in neonatal sepsis and non infectious neonatal neutropenia, in drug induced neutropenia and in HIV-positive patients. Treatment is generally well tolerated and granulocyte colony stimulating factor appears better tolerated than granulocyte and macrophage colony stimulating factor. Economically colony stimulating factors have not been shown to induce excessive costs for a given patient. CONCLUSION: In general the adult guidelines are applicable to children but additional considerations (aggressive or very progressive childhood neoplasms, specific indications, neonatal use, congenital disorders) must be taken into account.en
dc.language.isoenen
dc.subjectHaematologic Diseasesen
dc.subjectHaematopoietic Stem Cell Transplantationen
dc.subjectLeukaemiaen
dc.subject.meshBone Marrow Transplantation-
dc.subject.meshChild-
dc.subject.meshColony-Stimulating Factors-
dc.subject.meshEurope-
dc.subject.meshGranulocyte Colony-Stimulating Factor-
dc.subject.meshGranulocyte-Macrophage Colony-Stimulating Factor-
dc.subject.meshHematologic Diseases-
dc.subject.meshHematopoietic Stem Cell Transplantation-
dc.subject.meshHumans-
dc.subject.meshLeukemia-
dc.subject.meshNeutropenia-
dc.titleRecommendations on the use of colony-stimulating factors in children: conclusions of a European panel.en
dc.typeArticleen
dc.contributor.departmentHospital Saint-Louis, Paris, France.en
dc.identifier.journalEuropean Journal of Pediatricsen
All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.