2.50
Hdl Handle:
http://hdl.handle.net/10541/91676
Title:
Management of chemotherapy-induced anemia in solid tumors.
Authors:
Thatcher, Nick
Abstract:
Patients with cancer have inappropriately low levels of endogenous erythropoietin for the degree of anemia and further suppression of erythropoiesis results from chemotherapy. Patients with lung cancer, in particular, require a high frequency of transfusions, as they are unable to tolerate the symptoms of anemia due to their underlying pulmonary disease and, often, their age. Data from phase I and II trials indicated that epoetin alfa could increase hemoglobin concentration and reduce transfusion requirements. The beneficial response was dose dependent. These findings were confirmed in a series of three double-blind, placebo-controlled, multicenter phase III trials. Clinical trial evidence indicates that 150 IU/kg epoetin alfa three times weekly effectively treats anemia and decreases transfusion requirements in most cancer patients after the first month of chemotherapy. Furthermore, epoetin alfa will reduce the degree of anemia and markedly reduce the need for transfusions, thereby preventing anemia in patients undergoing multiple cycles of platinum-based combination chemotherapy. Epoetin alfa is well tolerated and shows marked activity in preventing anemia and reducing blood transfusion requirements in patients undergoing cyclic chemotherapy.
Affiliation:
CRC Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Management of chemotherapy-induced anemia in solid tumors. 1998, 25 (3 Suppl 7):23-6 Semin. Oncol.
Journal:
Seminars in Oncology
Issue Date:
Jun-1998
URI:
http://hdl.handle.net/10541/91676
PubMed ID:
9671326
Type:
Article
Language:
en
ISSN:
0093-7754
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorThatcher, Nicken
dc.date.accessioned2010-02-09T16:51:08Z-
dc.date.available2010-02-09T16:51:08Z-
dc.date.issued1998-06-
dc.identifier.citationManagement of chemotherapy-induced anemia in solid tumors. 1998, 25 (3 Suppl 7):23-6 Semin. Oncol.en
dc.identifier.issn0093-7754-
dc.identifier.pmid9671326-
dc.identifier.urihttp://hdl.handle.net/10541/91676-
dc.description.abstractPatients with cancer have inappropriately low levels of endogenous erythropoietin for the degree of anemia and further suppression of erythropoiesis results from chemotherapy. Patients with lung cancer, in particular, require a high frequency of transfusions, as they are unable to tolerate the symptoms of anemia due to their underlying pulmonary disease and, often, their age. Data from phase I and II trials indicated that epoetin alfa could increase hemoglobin concentration and reduce transfusion requirements. The beneficial response was dose dependent. These findings were confirmed in a series of three double-blind, placebo-controlled, multicenter phase III trials. Clinical trial evidence indicates that 150 IU/kg epoetin alfa three times weekly effectively treats anemia and decreases transfusion requirements in most cancer patients after the first month of chemotherapy. Furthermore, epoetin alfa will reduce the degree of anemia and markedly reduce the need for transfusions, thereby preventing anemia in patients undergoing multiple cycles of platinum-based combination chemotherapy. Epoetin alfa is well tolerated and shows marked activity in preventing anemia and reducing blood transfusion requirements in patients undergoing cyclic chemotherapy.en
dc.language.isoenen
dc.subjectAnaemiaen
dc.subjectCanceren
dc.subjectHaematinicsen
dc.subject.meshAnemia-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshClinical Trials as Topic-
dc.subject.meshEpoetin Alfa-
dc.subject.meshHematinics-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.titleManagement of chemotherapy-induced anemia in solid tumors.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalSeminars in Oncologyen

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