Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91666
Title:
Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.
Authors:
Taylor, G Malcolm; Dearden, Simon; Payne, N; Ayres, Michelle; Gokhale, D A; Birch, Jillian M; Blair, Val; Stevens, Richard F; Will, Andrew M; Eden, Tim O B
Abstract:
Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.
Affiliation:
Immunogenetics Laboratory, St Mary's Hospital, Manchester, UK.
Citation:
Evidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology. 1998, 78 (5):561-5 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Sep-1998
URI:
http://hdl.handle.net/10541/91666
PubMed ID:
9744491
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorTaylor, G Malcolmen
dc.contributor.authorDearden, Simonen
dc.contributor.authorPayne, Nen
dc.contributor.authorAyres, Michelleen
dc.contributor.authorGokhale, D Aen
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorBlair, Valen
dc.contributor.authorStevens, Richard Fen
dc.contributor.authorWill, Andrew Men
dc.contributor.authorEden, Tim O Ben
dc.date.accessioned2010-02-09T16:52:28Z-
dc.date.available2010-02-09T16:52:28Z-
dc.date.issued1998-09-
dc.identifier.citationEvidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology. 1998, 78 (5):561-5 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid9744491-
dc.identifier.urihttp://hdl.handle.net/10541/91666-
dc.description.abstractComparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects. The results suggest a male-associated susceptibility haplotype in c-ALL and supports an infectious aetiology.en
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAlleles-
dc.subject.meshAntigen Presentation-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshCommunicable Diseases-
dc.subject.meshDNA-
dc.subject.meshDisease Susceptibility-
dc.subject.meshFemale-
dc.subject.meshGene Frequency-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHLA-DQ Antigens-
dc.subject.meshHaplotypes-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshMale-
dc.subject.meshPolymorphism, Single-Stranded Conformational-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshSex Factors-
dc.titleEvidence that an HLA-DQA1-DQB1 haplotype influences susceptibility to childhood common acute lymphoblastic leukaemia in boys provides further support for an infection-related aetiology.en
dc.typeArticleen
dc.contributor.departmentImmunogenetics Laboratory, St Mary's Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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