Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91573
Title:
Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample.
Authors:
Völzke, Henry; Nauck, Matthias; Rettig, Rainer; Dörr, Marcus; Higham, Claire E; Brabant, Georg E; Wallaschofski, Henri
Abstract:
CONTEXT: It is assumed that hepatic steatosis plays a role in the development and progression of the metabolic syndrome and its cardiovascular sequelae. Low serum IGF1 levels might mediate these associations. OBJECTIVES: The aims of this study were i) to investigate the associations of hepatic steatosis with serum IGF1 and IGF binding protein-3 (IGFBP-3) levels using ultrasound and serum alanine aminotransaminase (ALT) data to define hepatic steatosis, and ii) to analyze the specific role of alcohol consumption in this context. DESIGN: We analyzed data from the population-based Study of Health in Pomerania. METHODS: We used data from 3863 subjects (1971 women) aged 20-79 years who had no history of viral hepatitis, liver cirrhosis, or malignant diseases. Liver hyperechogenicity was diagnosed using ultrasound. Serum IGF1 and IGFBP-3 levels were determined by automated two-site chemiluminescence immunoassays. RESULTS: Hyperechogenic liver pattern was associated with low serum IGF1 levels and low serum IGF1/IGFBP-3 ratios. The lowest serum IGF1 and IGF1/IGFBP-3 values and highest IGFBP-3 levels were present in subjects who had a hyperechogenic liver pattern and increased serum ALT levels. All of these associations were independent of alcohol consumption. CONCLUSIONS: Our data show that hepatic steatosis is associated with low serum IGF1 levels. This association is independent of alcohol consumption.
Affiliation:
Institute of Community Medicine Institute of Clinical Chemistry and Laboratory Medicine Institute of Physiology Department of Internal Medicine B, University of Greifswald, Greifswald D-17487, Germany. voelzke@uni-greifswald.de
Citation:
Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample. 2009, 161 (5):705-13 Eur. J. Endocrinol.
Journal:
European Journal of Endocrinology
Issue Date:
Nov-2009
URI:
http://hdl.handle.net/10541/91573
DOI:
10.1530/EJE-09-0374
PubMed ID:
19690083
Type:
Article
Language:
en
ISSN:
1479-683X
Appears in Collections:
All Christie Publications ; Endocrinology

Full metadata record

DC FieldValue Language
dc.contributor.authorVölzke, Henryen
dc.contributor.authorNauck, Matthiasen
dc.contributor.authorRettig, Raineren
dc.contributor.authorDörr, Marcusen
dc.contributor.authorHigham, Claire Een
dc.contributor.authorBrabant, Georg Een
dc.contributor.authorWallaschofski, Henrien
dc.date.accessioned2010-02-09T11:12:33Z-
dc.date.available2010-02-09T11:12:33Z-
dc.date.issued2009-11-
dc.identifier.citationAssociation between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample. 2009, 161 (5):705-13 Eur. J. Endocrinol.en
dc.identifier.issn1479-683X-
dc.identifier.pmid19690083-
dc.identifier.doi10.1530/EJE-09-0374-
dc.identifier.urihttp://hdl.handle.net/10541/91573-
dc.description.abstractCONTEXT: It is assumed that hepatic steatosis plays a role in the development and progression of the metabolic syndrome and its cardiovascular sequelae. Low serum IGF1 levels might mediate these associations. OBJECTIVES: The aims of this study were i) to investigate the associations of hepatic steatosis with serum IGF1 and IGF binding protein-3 (IGFBP-3) levels using ultrasound and serum alanine aminotransaminase (ALT) data to define hepatic steatosis, and ii) to analyze the specific role of alcohol consumption in this context. DESIGN: We analyzed data from the population-based Study of Health in Pomerania. METHODS: We used data from 3863 subjects (1971 women) aged 20-79 years who had no history of viral hepatitis, liver cirrhosis, or malignant diseases. Liver hyperechogenicity was diagnosed using ultrasound. Serum IGF1 and IGFBP-3 levels were determined by automated two-site chemiluminescence immunoassays. RESULTS: Hyperechogenic liver pattern was associated with low serum IGF1 levels and low serum IGF1/IGFBP-3 ratios. The lowest serum IGF1 and IGF1/IGFBP-3 values and highest IGFBP-3 levels were present in subjects who had a hyperechogenic liver pattern and increased serum ALT levels. All of these associations were independent of alcohol consumption. CONCLUSIONS: Our data show that hepatic steatosis is associated with low serum IGF1 levels. This association is independent of alcohol consumption.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAlanine Transaminase-
dc.subject.meshAlcohol Drinking-
dc.subject.meshAspartate Aminotransferases-
dc.subject.meshCross-Sectional Studies-
dc.subject.meshFatty Liver-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInsulin-Like Growth Factor Binding Proteins-
dc.subject.meshInsulin-Like Growth Factor I-
dc.subject.meshLogistic Models-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMultivariate Analysis-
dc.subject.meshTransferrin-
dc.subject.meshYoung Adult-
dc.subject.meshgamma-Glutamyltransferase-
dc.titleAssociation between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample.en
dc.typeArticleen
dc.contributor.departmentInstitute of Community Medicine Institute of Clinical Chemistry and Laboratory Medicine Institute of Physiology Department of Internal Medicine B, University of Greifswald, Greifswald D-17487, Germany. voelzke@uni-greifswald.deen
dc.identifier.journalEuropean Journal of Endocrinologyen

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