Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats.

2.50
Hdl Handle:
http://hdl.handle.net/10541/91473
Title:
Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats.
Authors:
Buchenauer, T; Behrendt, P; Bode, F J; Horn, R; Brabant, Georg E; Stephan, M; Nave, H
Abstract:
Obesity is an increasing socio-economic health problem. Diet-induced obese (DIO) rodents are widely used as a model of obesity in humans. However, there is no comprehensive data about the behavioral phenotype of DIO rodents. Therefore, the aim of the present study was to determine whether a high-fat-diet changes behavioral patterns of DIO Fischer 344 (F344) rats in comparison with lean littermates. The behavioral tests (homecage, holeboard, social interaction, and hotplate) were performed in 28 normal-weight and 28 male DIO F344 rats (mean age: 16 weeks) and revealed a significantly higher level of anxiety- and aggression-related parameters in obese rats, whereas their pain threshold was significantly lower. Fitting to a different behavioral response, basal corticosterone levels (measured by RIA) of obese animals were significantly elevated (16.0ng/ml vs. 12.5ng/ml; p<0.01). We conclude that obese rats differ in various aspects from their lean littermates. The altered behavioral characteristics displayed by DIO F344 rats have to be considered in further experiments involving DIO rodents.
Affiliation:
Institute for Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany.
Citation:
Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats. 2009, 98 (5):563-9 Physiol. Behav.
Journal:
Physiology & Behavior
Issue Date:
7-Dec-2009
URI:
http://hdl.handle.net/10541/91473
DOI:
10.1016/j.physbeh.2009.09.003
PubMed ID:
19751751
Type:
Article
Language:
en
ISSN:
1873-507X
Appears in Collections:
All Christie Publications ; Endocrinology

Full metadata record

DC FieldValue Language
dc.contributor.authorBuchenauer, Ten
dc.contributor.authorBehrendt, Pen
dc.contributor.authorBode, F Jen
dc.contributor.authorHorn, Ren
dc.contributor.authorBrabant, Georg Een
dc.contributor.authorStephan, Men
dc.contributor.authorNave, Hen
dc.date.accessioned2010-02-09T10:28:58Z-
dc.date.available2010-02-09T10:28:58Z-
dc.date.issued2009-12-07-
dc.identifier.citationDiet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats. 2009, 98 (5):563-9 Physiol. Behav.en
dc.identifier.issn1873-507X-
dc.identifier.pmid19751751-
dc.identifier.doi10.1016/j.physbeh.2009.09.003-
dc.identifier.urihttp://hdl.handle.net/10541/91473-
dc.description.abstractObesity is an increasing socio-economic health problem. Diet-induced obese (DIO) rodents are widely used as a model of obesity in humans. However, there is no comprehensive data about the behavioral phenotype of DIO rodents. Therefore, the aim of the present study was to determine whether a high-fat-diet changes behavioral patterns of DIO Fischer 344 (F344) rats in comparison with lean littermates. The behavioral tests (homecage, holeboard, social interaction, and hotplate) were performed in 28 normal-weight and 28 male DIO F344 rats (mean age: 16 weeks) and revealed a significantly higher level of anxiety- and aggression-related parameters in obese rats, whereas their pain threshold was significantly lower. Fitting to a different behavioral response, basal corticosterone levels (measured by RIA) of obese animals were significantly elevated (16.0ng/ml vs. 12.5ng/ml; p<0.01). We conclude that obese rats differ in various aspects from their lean littermates. The altered behavioral characteristics displayed by DIO F344 rats have to be considered in further experiments involving DIO rodents.en
dc.language.isoenen
dc.subject.meshAggression-
dc.subject.meshAnalysis of Variance-
dc.subject.meshAnimals-
dc.subject.meshAnxiety-
dc.subject.meshBody Weight-
dc.subject.meshCorticosterone-
dc.subject.meshDiet-
dc.subject.meshDisease Models, Animal-
dc.subject.meshEmotional Intelligence-
dc.subject.meshExploratory Behavior-
dc.subject.meshHot Temperature-
dc.subject.meshMale-
dc.subject.meshObesity-
dc.subject.meshPain Threshold-
dc.subject.meshPhysical Stimulation-
dc.subject.meshRats-
dc.subject.meshRats, Inbred F344-
dc.titleDiet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats.en
dc.typeArticleen
dc.contributor.departmentInstitute for Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany.en
dc.identifier.journalPhysiology & Behavioren

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