2.50
Hdl Handle:
http://hdl.handle.net/10541/91374
Title:
Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).
Authors:
Sugimoto, Masataka; Nakamura, Takeshi; Ohtani, Naoko; Hampson, Lynne; Hampson, Ian N; Shimamoto, Akira; Furuichi, Yasuhiro; Okumura, Ko; Niwa, Shinichiro; Taya, Yoichi; Hara, Eiji
Abstract:
The p16(INK4a) tumor suppressor inhibits cyclin-dependent kinases (CDK4 and CDK6). Here we report the isolation of a novel gene, SEI-1, whose product (p34(SEI-1)) appears to antagonize the function of p16(INK4a). Addition of p34(SEI-1) to cyclin D1-CDK4 renders the complex resistant to inhibition by p16(INK4a). Expression of SEI-1 is rapidly induced on addition of serum to quiescent fibroblasts, and ectopic expression of p34(SEI-1) enables fibroblasts to proliferate even in low serum concentrations. p34(SEI-1) seems to act as a growth factor sensor and may facilitate the formation and activation of cyclin D-CDK complexes in the face of inhibitory levels of INK4 proteins.
Affiliation:
Paterson Institute for Cancer Research, Christie Hospital National Health Service Trust, Manchester, M20 4BX, UK.
Citation:
Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). 1999, 13 (22):3027-33 Genes Dev.
Journal:
Genes & Development
Issue Date:
15-Nov-1999
URI:
http://hdl.handle.net/10541/91374
PubMed ID:
10580009
Type:
Article
Language:
en
ISSN:
0890-9369
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSugimoto, Masatakaen
dc.contributor.authorNakamura, Takeshien
dc.contributor.authorOhtani, Naokoen
dc.contributor.authorHampson, Lynneen
dc.contributor.authorHampson, Ian Nen
dc.contributor.authorShimamoto, Akiraen
dc.contributor.authorFuruichi, Yasuhiroen
dc.contributor.authorOkumura, Koen
dc.contributor.authorNiwa, Shinichiroen
dc.contributor.authorTaya, Yoichien
dc.contributor.authorHara, Eijien
dc.date.accessioned2010-02-08T11:25:46Z-
dc.date.available2010-02-08T11:25:46Z-
dc.date.issued1999-11-15-
dc.identifier.citationRegulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). 1999, 13 (22):3027-33 Genes Dev.en
dc.identifier.issn0890-9369-
dc.identifier.pmid10580009-
dc.identifier.urihttp://hdl.handle.net/10541/91374-
dc.description.abstractThe p16(INK4a) tumor suppressor inhibits cyclin-dependent kinases (CDK4 and CDK6). Here we report the isolation of a novel gene, SEI-1, whose product (p34(SEI-1)) appears to antagonize the function of p16(INK4a). Addition of p34(SEI-1) to cyclin D1-CDK4 renders the complex resistant to inhibition by p16(INK4a). Expression of SEI-1 is rapidly induced on addition of serum to quiescent fibroblasts, and ectopic expression of p34(SEI-1) enables fibroblasts to proliferate even in low serum concentrations. p34(SEI-1) seems to act as a growth factor sensor and may facilitate the formation and activation of cyclin D-CDK complexes in the face of inhibitory levels of INK4 proteins.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshBlood Physiological Phenomena-
dc.subject.meshCOS Cells-
dc.subject.meshCarrier Proteins-
dc.subject.meshCell Cycle-
dc.subject.meshCells, Cultured-
dc.subject.meshCercopithecus aethiops-
dc.subject.meshChromosomes, Human, Pair 19-
dc.subject.meshCulture Media, Serum-Free-
dc.subject.meshCyclin-Dependent Kinase 4-
dc.subject.meshCyclin-Dependent Kinase Inhibitor p16-
dc.subject.meshCyclin-Dependent Kinases-
dc.subject.meshDNA, Complementary-
dc.subject.meshEnzyme Activation-
dc.subject.meshFibroblasts-
dc.subject.meshGenes-
dc.subject.meshHela Cells-
dc.subject.meshHumans-
dc.subject.meshNuclear Proteins-
dc.subject.meshProto-Oncogene Proteins-
dc.subject.meshSaccharomyces cerevisiae-
dc.subject.meshTrans-Activators-
dc.subject.meshTransfection-
dc.subject.meshTwo-Hybrid System Techniques-
dc.titleRegulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital National Health Service Trust, Manchester, M20 4BX, UK.en
dc.identifier.journalGenes & Developmenten

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