2.50
Hdl Handle:
http://hdl.handle.net/10541/91373
Title:
Synthesis and anticancer activities of 4-oxobenzopyrano[2,3-d]pyrimidines.
Authors:
Hadfield, John A; Pavlidis, V H; Perry, P J; McGown, Alan T
Abstract:
Several 2-aryl-4-oxoxbenzopyrano[2,3-d]pyrimidines have previously been shown to exhibit in vivo antitumor activity in mice with P388 lymphocytic leukemia. In the present study, a series of novel substituted benzopyrano[2,3-d]pyrimidines have been prepared and tested for cytotoxic activity against a panel of cancer cell lines including the P388 lymphocytic leukemia cell line. The unsubstituted parent compound, some methoxylated derivatives and a cyclohexyl derivative all exhibited potent cytotoxic activity (IC50 values 0.3-0.64 microM). A number of derivatives, including the unsubstituted parent pyrimidine, were shown to cause a significant perturbation in cell cycle kinetics with an observed 2- to 3-fold increase in cells in the G2/M phase of the cell cycle. Furthermore, a polymethoxylated derivative, 2-(3,4,5-trimethoxyphenyl)-9-methoxy-4-oxo-2,3-dihydrobenzopyrano[ 2,3-d]pyrimidine 13, was shown to be selectively active against a number of human ovarian cell lines.
Affiliation:
Cancer Research Campaign Section of Drug Development and Imaging, Paterson Institute for Cancer Research, Manchester, UK. jhadfield@picr.man.ac.uk
Citation:
Synthesis and anticancer activities of 4-oxobenzopyrano[2,3-d]pyrimidines. 1999, 10 (6):591-5 Anticancer Drugs
Journal:
Anti-Cancer Drugs
Issue Date:
Jul-1999
URI:
http://hdl.handle.net/10541/91373
PubMed ID:
10885907
Type:
Article
Language:
en
ISSN:
0959-4973
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHadfield, John Aen
dc.contributor.authorPavlidis, V Hen
dc.contributor.authorPerry, P Jen
dc.contributor.authorMcGown, Alan Ten
dc.date.accessioned2010-02-08T11:24:55Z-
dc.date.available2010-02-08T11:24:55Z-
dc.date.issued1999-07-
dc.identifier.citationSynthesis and anticancer activities of 4-oxobenzopyrano[2,3-d]pyrimidines. 1999, 10 (6):591-5 Anticancer Drugsen
dc.identifier.issn0959-4973-
dc.identifier.pmid10885907-
dc.identifier.urihttp://hdl.handle.net/10541/91373-
dc.description.abstractSeveral 2-aryl-4-oxoxbenzopyrano[2,3-d]pyrimidines have previously been shown to exhibit in vivo antitumor activity in mice with P388 lymphocytic leukemia. In the present study, a series of novel substituted benzopyrano[2,3-d]pyrimidines have been prepared and tested for cytotoxic activity against a panel of cancer cell lines including the P388 lymphocytic leukemia cell line. The unsubstituted parent compound, some methoxylated derivatives and a cyclohexyl derivative all exhibited potent cytotoxic activity (IC50 values 0.3-0.64 microM). A number of derivatives, including the unsubstituted parent pyrimidine, were shown to cause a significant perturbation in cell cycle kinetics with an observed 2- to 3-fold increase in cells in the G2/M phase of the cell cycle. Furthermore, a polymethoxylated derivative, 2-(3,4,5-trimethoxyphenyl)-9-methoxy-4-oxo-2,3-dihydrobenzopyrano[ 2,3-d]pyrimidine 13, was shown to be selectively active against a number of human ovarian cell lines.en
dc.language.isoenen
dc.subjectLeukaemia P388en
dc.subjectOvarian Canceren
dc.subjectCultured Tumour Cellsen
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshCell Cycle-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshK562 Cells-
dc.subject.meshKinetics-
dc.subject.meshLeukemia P388-
dc.subject.meshMagnetic Resonance Spectroscopy-
dc.subject.meshMass Spectrometry-
dc.subject.meshMice-
dc.subject.meshOvarian Neoplasms-
dc.subject.meshPyrimidines-
dc.subject.meshTumor Cells, Cultured-
dc.titleSynthesis and anticancer activities of 4-oxobenzopyrano[2,3-d]pyrimidines.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Section of Drug Development and Imaging, Paterson Institute for Cancer Research, Manchester, UK. jhadfield@picr.man.ac.uken
dc.identifier.journalAnti-Cancer Drugsen

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