Estrogen receptor-positive proliferating cells in the normal and precancerous breast.

2.50
Hdl Handle:
http://hdl.handle.net/10541/90805
Title:
Estrogen receptor-positive proliferating cells in the normal and precancerous breast.
Authors:
Shoker, Balvinder S; Jarvis, Christine; Clarke, Robert B; Anderson, Elizabeth; Hewlett, Joanne; Davies, Michael P; Sibson, D Ross; Sloane, John P
Abstract:
Recently it has been shown that epithelial cell expression of the estrogen receptor (ER) and that of the proliferation-associated marker Ki-67 are almost mutually exclusive in the normal premenopausal human breast but that coexpression frequently occurs in estrogen receptor-positive (ER+) breast cancers. This coexpression may indicate disordered expression of ER in the cell cycle or failure to suppress division of ER+ cells and could be important in neoplastic transformation. The purpose of this study was to determine whether in situ proliferations known to be associated with different levels of risk for developing breast cancer contain these coexpressing cells and, if so, the stage at which they occur. We found that ER+ proliferating cells were rare in premenopausal lobules but increased with age in the normal breast. There was no difference in nonlesional tissue between cancerous and noncancerous breasts. The percentage of dual-expressing cells was significantly increased, however, in all of the in situ proliferations and correlated positively with the level of risk of developing breast cancer. We suggest that development of at least some human breast cancers is associated with increasing failure to down-regulate ER as cells enter the cycle or to suppress division of ER+ cells. The mechanism may involve the loss of a tumor suppressor gene.
Affiliation:
Department of Pathology, University of Liverpool, Liverpool. United Kingdom.
Citation:
Estrogen receptor-positive proliferating cells in the normal and precancerous breast. 1999, 155 (6):1811-5 Am. J. Pathol.
Journal:
American Journal of Pathology
Issue Date:
Dec-1999
URI:
http://hdl.handle.net/10541/90805
PubMed ID:
10595909
Type:
Article
Language:
en
ISSN:
0002-9440
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorShoker, Balvinder Sen
dc.contributor.authorJarvis, Christineen
dc.contributor.authorClarke, Robert Ben
dc.contributor.authorAnderson, Elizabethen
dc.contributor.authorHewlett, Joanneen
dc.contributor.authorDavies, Michael Pen
dc.contributor.authorSibson, D Rossen
dc.contributor.authorSloane, John Pen
dc.date.accessioned2010-01-28T12:21:05Z-
dc.date.available2010-01-28T12:21:05Z-
dc.date.issued1999-12-
dc.identifier.citationEstrogen receptor-positive proliferating cells in the normal and precancerous breast. 1999, 155 (6):1811-5 Am. J. Pathol.en
dc.identifier.issn0002-9440-
dc.identifier.pmid10595909-
dc.identifier.urihttp://hdl.handle.net/10541/90805-
dc.description.abstractRecently it has been shown that epithelial cell expression of the estrogen receptor (ER) and that of the proliferation-associated marker Ki-67 are almost mutually exclusive in the normal premenopausal human breast but that coexpression frequently occurs in estrogen receptor-positive (ER+) breast cancers. This coexpression may indicate disordered expression of ER in the cell cycle or failure to suppress division of ER+ cells and could be important in neoplastic transformation. The purpose of this study was to determine whether in situ proliferations known to be associated with different levels of risk for developing breast cancer contain these coexpressing cells and, if so, the stage at which they occur. We found that ER+ proliferating cells were rare in premenopausal lobules but increased with age in the normal breast. There was no difference in nonlesional tissue between cancerous and noncancerous breasts. The percentage of dual-expressing cells was significantly increased, however, in all of the in situ proliferations and correlated positively with the level of risk of developing breast cancer. We suggest that development of at least some human breast cancers is associated with increasing failure to down-regulate ER as cells enter the cycle or to suppress division of ER+ cells. The mechanism may involve the loss of a tumor suppressor gene.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectOestrogen Receptors-
dc.subject.meshBreast-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma in Situ-
dc.subject.meshCarcinoma, Ductal, Breast-
dc.subject.meshCell Cycle-
dc.subject.meshCell Division-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshDown-Regulation-
dc.subject.meshFemale-
dc.subject.meshFluorescent Antibody Technique-
dc.subject.meshHumans-
dc.subject.meshHyperplasia-
dc.subject.meshKi-67 Antigen-
dc.subject.meshPostmenopause-
dc.subject.meshPrecancerous Conditions-
dc.subject.meshPremenopause-
dc.subject.meshReceptors, Estrogen-
dc.titleEstrogen receptor-positive proliferating cells in the normal and precancerous breast.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, University of Liverpool, Liverpool. United Kingdom.en
dc.identifier.journalAmerican Journal of Pathologyen

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