2.50
Hdl Handle:
http://hdl.handle.net/10541/90803
Title:
Does HLA type predispose some individuals to cancer?
Authors:
Little, Ann-Margaret; Stern, Peter L
Abstract:
Polymorphic human major histocompatibility complex (MHC) genes are pivotal to the functioning immune system, and strong autoimmune disease associations with human leukocyte antigens (HLAs) have been established, although the precise mechanisms of these associations are not fully defined. There is now clear evidence of immunosurveillance in cancer, thus it seems reasonable to hypothesize that HLA types might predispose some individuals to particular malignancies. In addition, HLAs could influence the susceptibility or progression of a malignancy, and this might be most apparent in virally associated cancers. This article discusses the results and problems of searching for such HLAs and cancer associations. To date, it appears that no strong associations between HLAs and cancer risk exist.
Affiliation:
The Anthony Nolan Bone Marrow Trust, The Royal Free Hospital, Hampstead, London, UK NW3 2QG.
Citation:
Does HLA type predispose some individuals to cancer? 1999, 5 (8):337-42 Mol Med Today
Journal:
Molecular Medicine Today
Issue Date:
Aug-1999
URI:
http://hdl.handle.net/10541/90803
DOI:
10.1016/S1357-4310(99)01524-5
PubMed ID:
10431166
Type:
Article
Language:
en
ISSN:
1357-4310
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLittle, Ann-Margareten
dc.contributor.authorStern, Peter Len
dc.date.accessioned2010-01-28T12:18:00Z-
dc.date.available2010-01-28T12:18:00Z-
dc.date.issued1999-08-
dc.identifier.citationDoes HLA type predispose some individuals to cancer? 1999, 5 (8):337-42 Mol Med Todayen
dc.identifier.issn1357-4310-
dc.identifier.pmid10431166-
dc.identifier.doi10.1016/S1357-4310(99)01524-5-
dc.identifier.urihttp://hdl.handle.net/10541/90803-
dc.description.abstractPolymorphic human major histocompatibility complex (MHC) genes are pivotal to the functioning immune system, and strong autoimmune disease associations with human leukocyte antigens (HLAs) have been established, although the precise mechanisms of these associations are not fully defined. There is now clear evidence of immunosurveillance in cancer, thus it seems reasonable to hypothesize that HLA types might predispose some individuals to particular malignancies. In addition, HLAs could influence the susceptibility or progression of a malignancy, and this might be most apparent in virally associated cancers. This article discusses the results and problems of searching for such HLAs and cancer associations. To date, it appears that no strong associations between HLAs and cancer risk exist.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAutoimmunity-
dc.subject.meshHLA Antigens-
dc.subject.meshHumans-
dc.subject.meshMajor Histocompatibility Complex-
dc.subject.meshNeoplasms-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshReceptors, Antigen, T-Cell-
dc.subject.meshRisk Factors-
dc.subject.meshT-Lymphocytes-
dc.subject.meshViruses-
dc.titleDoes HLA type predispose some individuals to cancer?en
dc.typeArticleen
dc.contributor.departmentThe Anthony Nolan Bone Marrow Trust, The Royal Free Hospital, Hampstead, London, UK NW3 2QG.en
dc.identifier.journalMolecular Medicine Todayen

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