Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.

2.50
Hdl Handle:
http://hdl.handle.net/10541/90801
Title:
Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.
Authors:
Burt, E C; McGown, Gail; Thorncroft, Mary R; James, Louise A; Birch, Jillian M; Varley, Jennifer
Abstract:
We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested.
Affiliation:
CRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome. 1999, 80 (1-2):9-10 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Apr-1999
URI:
http://hdl.handle.net/10541/90801
DOI:
10.1038/sj.bjc.6690313
PubMed ID:
10389970
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBurt, E Cen
dc.contributor.authorMcGown, Gailen
dc.contributor.authorThorncroft, Mary Ren
dc.contributor.authorJames, Louise Aen
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorVarley, Jenniferen
dc.date.accessioned2010-01-28T12:11:33Z-
dc.date.available2010-01-28T12:11:33Z-
dc.date.issued1999-04-
dc.identifier.citationExclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome. 1999, 80 (1-2):9-10 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid10389970-
dc.identifier.doi10.1038/sj.bjc.6690313-
dc.identifier.urihttp://hdl.handle.net/10541/90801-
dc.description.abstractWe have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested.en
dc.language.isoenen
dc.subjectTumour Suppressor Genesen
dc.subjectTumour Suppressor Proteinsen
dc.subject.meshDNA Mutational Analysis-
dc.subject.meshGenes, Tumor Suppressor-
dc.subject.meshGenes, p16-
dc.subject.meshGenes, p53-
dc.subject.meshHumans-
dc.subject.meshLi-Fraumeni Syndrome-
dc.subject.meshMutation-
dc.subject.meshPTEN Phosphohydrolase-
dc.subject.meshPedigree-
dc.subject.meshPhosphoric Monoester Hydrolases-
dc.subject.meshTumor Suppressor Proteins-
dc.titleExclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.en
dc.typeArticleen
dc.contributor.departmentCRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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