Loss of heterozygosity at 11q23.1 and survival in breast cancer: results of a large European study. Breast Cancer Somatic Genetics Consortium.

2.50
Hdl Handle:
http://hdl.handle.net/10541/90795
Title:
Loss of heterozygosity at 11q23.1 and survival in breast cancer: results of a large European study. Breast Cancer Somatic Genetics Consortium.
Authors:
Laake, Kirsten; Launonen, Virpi; Niederacher, Dieter; Gudlaugsdottir, Sigfridur; Seitz, Susanne; Rio, Pascale; Champème, Marie-Helene; Bièche, Ivan; Birnbaum, Daniel; White, Gavin R M; Sztan, Marianna; Sever, Natasa; Plummer, Sarah; Osorio, Ana; Broeks, Annegien; Huusko, P; Spurr, Nigel; Borg, Ake; Cleton-Jansen, Anne-Marie; Van't Veer, Laura; Benitez, Javier; Casey, Graham; Peterlin, Borut; Olah, Edith; Børresen-Dale, Anne-Lise; Varley, Jennifer; Bignon, Yves-Jean; Scherneck, Siegfried; Sigurdardottir, Valgerdur; Lidereau, Rosette; Eyfjord, Jorunn; Beckmann, Matthias W; Winqvist, Robert; Skovlund, Eva
Abstract:
Among the chromosomal regions commonly undergoing deletions in breast tumors is 11q23.1. The genes that are targets for loss of heterozygosity (LOH) in this region is not yet established. One of the candidate genes located in this region is ATM, responsible for the rare autosomal recessive disorder ataxia-telangiectasia (A-T). Interestingly, A-T heterozygotes may have an increased risk of cancer, in particular breast cancer, although this is still controversial. A common assumption has been that the target for the LOH at 11q23.1 in breast carcinoma is the ATM gene, but the area studied has been too large, the density of markers too low, and the number of tumors studied has been too small to draw any firm conclusions. The present study is a multicenter study including 918 breast cancer patients with clinical information and survival data available for most of them. Primary breast tumors were investigated for LOH using a high density of microsatellite markers spanning approximately 6 Mb around the ATM gene. Survival analyses showed that there are most likely one or more candidate genes in a 3-4 Mb region between the markers D11S1819 and D11S927 including the ATM gene. Cancer-specific survival was significantly reduced in patients whose tumors exhibited LOH of markers D11S2179 (within the ATM gene), D11S1778, D11S1294, and D11S1818. The highest survival hazard ratios were 1.8(C11.2-2.8, P = 0.010) and 2.1 (C11.4-3.0, P = 0.0004) for markers D11S2179 and D11S1818, respectively. One or more of these markers are therefore most likely to be located close to or within genes associated with breast cancer survival.
Affiliation:
Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo.
Citation:
Loss of heterozygosity at 11q23.1 and survival in breast cancer: results of a large European study. Breast Cancer Somatic Genetics Consortium. 1999, 25 (3):212-21 Genes Chromosomes Cancer
Journal:
Genes, Chromosomes & Cancer
Issue Date:
Jul-1999
URI:
http://hdl.handle.net/10541/90795
DOI:
10.1002/(SICI)1098-2264(199907)25:3<212::AID-GCC3>3.0.CO;2-G
PubMed ID:
10379867
Type:
Article
Language:
en
ISSN:
1045-2257
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLaake, Kirstenen
dc.contributor.authorLaunonen, Virpien
dc.contributor.authorNiederacher, Dieteren
dc.contributor.authorGudlaugsdottir, Sigfriduren
dc.contributor.authorSeitz, Susanneen
dc.contributor.authorRio, Pascaleen
dc.contributor.authorChampème, Marie-Heleneen
dc.contributor.authorBièche, Ivanen
dc.contributor.authorBirnbaum, Danielen
dc.contributor.authorWhite, Gavin R Men
dc.contributor.authorSztan, Mariannaen
dc.contributor.authorSever, Natasaen
dc.contributor.authorPlummer, Sarahen
dc.contributor.authorOsorio, Anaen
dc.contributor.authorBroeks, Annegienen
dc.contributor.authorHuusko, Pen
dc.contributor.authorSpurr, Nigelen
dc.contributor.authorBorg, Akeen
dc.contributor.authorCleton-Jansen, Anne-Marieen
dc.contributor.authorVan't Veer, Lauraen
dc.contributor.authorBenitez, Javieren
dc.contributor.authorCasey, Grahamen
dc.contributor.authorPeterlin, Boruten
dc.contributor.authorOlah, Edithen
dc.contributor.authorBørresen-Dale, Anne-Liseen
dc.contributor.authorVarley, Jenniferen
dc.contributor.authorBignon, Yves-Jeanen
dc.contributor.authorScherneck, Siegfrieden
dc.contributor.authorSigurdardottir, Valgerduren
dc.contributor.authorLidereau, Rosetteen
dc.contributor.authorEyfjord, Jorunnen
dc.contributor.authorBeckmann, Matthias Wen
dc.contributor.authorWinqvist, Roberten
dc.contributor.authorSkovlund, Evaen
dc.date.accessioned2010-01-28T11:39:01Z-
dc.date.available2010-01-28T11:39:01Z-
dc.date.issued1999-07-
dc.identifier.citationLoss of heterozygosity at 11q23.1 and survival in breast cancer: results of a large European study. Breast Cancer Somatic Genetics Consortium. 1999, 25 (3):212-21 Genes Chromosomes Canceren
dc.identifier.issn1045-2257-
dc.identifier.pmid10379867-
dc.identifier.doi10.1002/(SICI)1098-2264(199907)25:3<212::AID-GCC3>3.0.CO;2-G-
dc.identifier.urihttp://hdl.handle.net/10541/90795-
dc.description.abstractAmong the chromosomal regions commonly undergoing deletions in breast tumors is 11q23.1. The genes that are targets for loss of heterozygosity (LOH) in this region is not yet established. One of the candidate genes located in this region is ATM, responsible for the rare autosomal recessive disorder ataxia-telangiectasia (A-T). Interestingly, A-T heterozygotes may have an increased risk of cancer, in particular breast cancer, although this is still controversial. A common assumption has been that the target for the LOH at 11q23.1 in breast carcinoma is the ATM gene, but the area studied has been too large, the density of markers too low, and the number of tumors studied has been too small to draw any firm conclusions. The present study is a multicenter study including 918 breast cancer patients with clinical information and survival data available for most of them. Primary breast tumors were investigated for LOH using a high density of microsatellite markers spanning approximately 6 Mb around the ATM gene. Survival analyses showed that there are most likely one or more candidate genes in a 3-4 Mb region between the markers D11S1819 and D11S927 including the ATM gene. Cancer-specific survival was significantly reduced in patients whose tumors exhibited LOH of markers D11S2179 (within the ATM gene), D11S1778, D11S1294, and D11S1818. The highest survival hazard ratios were 1.8(C11.2-2.8, P = 0.010) and 2.1 (C11.4-3.0, P = 0.0004) for markers D11S2179 and D11S1818, respectively. One or more of these markers are therefore most likely to be located close to or within genes associated with breast cancer survival.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma, Ductal, Breast-
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Human, Pair 11-
dc.subject.meshFemale-
dc.subject.meshGenetic Markers-
dc.subject.meshHumans-
dc.subject.meshLoss of Heterozygosity-
dc.subject.meshMiddle Aged-
dc.subject.meshSurvival Rate-
dc.subject.meshTranslocation, Genetic-
dc.titleLoss of heterozygosity at 11q23.1 and survival in breast cancer: results of a large European study. Breast Cancer Somatic Genetics Consortium.en
dc.typeArticleen
dc.contributor.departmentDepartment of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo.en
dc.identifier.journalGenes, Chromosomes & Canceren

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