Genotoxicity studies on the azo dye Direct Red 2 using the in vivo mouse bone marrow micronucleus test.

2.50
Hdl Handle:
http://hdl.handle.net/10541/90777
Title:
Genotoxicity studies on the azo dye Direct Red 2 using the in vivo mouse bone marrow micronucleus test.
Authors:
Rajaguru, P; Fairbairn, Leslie J; Ashby, J; Willington, Mark; Turner, Suzanne D; Woolford, L A; Chinnasamy, Nachimuthu; Rafferty, Joseph A
Abstract:
The clastogenicity of the azo dye Direct Red 2 (DR2) has been investigated using the murine bone marrow micronucleus assay. A potent dose-dependent response was observed following oral gavage of DR2 up to 4 mg/kg, after which significant toxicity to the erythroid compartment was observed. The route of administration had a significant effect on the frequency of micronucleus formation: intraperitoneal injection was approximately two-fold less clastogenic than the equivalent dose delivered orally (p<0.05). The requirement for activation of DR2 by intestinal microflora was indicated by the fact that mice given acid-treated water prior to administration of DR2 showed a significant reduction (40%; p<0.001) in micronucleated polychromatic erythrocyte formation. The implications of these findings for the health and safety of occupationally exposed workers are discussed.
Affiliation:
PSG College of Arts and Science, Coimbatore, India.
Citation:
Genotoxicity studies on the azo dye Direct Red 2 using the in vivo mouse bone marrow micronucleus test. 1999, 444 (1):175-80 Mutat. Res.
Journal:
Mutation Research
Issue Date:
21-Jul-1999
URI:
http://hdl.handle.net/10541/90777
DOI:
10.1016/S1383-5718(99)00081-9
PubMed ID:
10477352
Type:
Article
Language:
en
ISSN:
0027-5107
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorRajaguru, Pen
dc.contributor.authorFairbairn, Leslie Jen
dc.contributor.authorAshby, Jen
dc.contributor.authorWillington, Marken
dc.contributor.authorTurner, Suzanne Den
dc.contributor.authorWoolford, L Aen
dc.contributor.authorChinnasamy, Nachimuthuen
dc.contributor.authorRafferty, Joseph Aen
dc.date.accessioned2010-01-28T10:01:26Z-
dc.date.available2010-01-28T10:01:26Z-
dc.date.issued1999-07-21-
dc.identifier.citationGenotoxicity studies on the azo dye Direct Red 2 using the in vivo mouse bone marrow micronucleus test. 1999, 444 (1):175-80 Mutat. Res.en
dc.identifier.issn0027-5107-
dc.identifier.pmid10477352-
dc.identifier.doi10.1016/S1383-5718(99)00081-9-
dc.identifier.urihttp://hdl.handle.net/10541/90777-
dc.description.abstractThe clastogenicity of the azo dye Direct Red 2 (DR2) has been investigated using the murine bone marrow micronucleus assay. A potent dose-dependent response was observed following oral gavage of DR2 up to 4 mg/kg, after which significant toxicity to the erythroid compartment was observed. The route of administration had a significant effect on the frequency of micronucleus formation: intraperitoneal injection was approximately two-fold less clastogenic than the equivalent dose delivered orally (p<0.05). The requirement for activation of DR2 by intestinal microflora was indicated by the fact that mice given acid-treated water prior to administration of DR2 showed a significant reduction (40%; p<0.001) in micronucleated polychromatic erythrocyte formation. The implications of these findings for the health and safety of occupationally exposed workers are discussed.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshAzo Compounds-
dc.subject.meshBiotransformation-
dc.subject.meshBone Marrow Cells-
dc.subject.meshColoring Agents-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshHumans-
dc.subject.meshIntestines-
dc.subject.meshMale-
dc.subject.meshMice-
dc.subject.meshMicronucleus Tests-
dc.subject.meshMutagens-
dc.subject.meshNaphthalenesulfonates-
dc.subject.meshPublic Health-
dc.titleGenotoxicity studies on the azo dye Direct Red 2 using the in vivo mouse bone marrow micronucleus test.en
dc.typeArticleen
dc.contributor.departmentPSG College of Arts and Science, Coimbatore, India.en
dc.identifier.journalMutation Researchen
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