Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome.

2.50
Hdl Handle:
http://hdl.handle.net/10541/90761
Title:
Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome.
Authors:
De Gruijl, Tanja D; Bontkes, Hetty J; Walboomers, Jan M; Coursaget, Pierre; Stukart, Marij J; Dupuy, Catherine; Kueter, Esther; Verheijen, René H; Helmerhorst, Theo J; Duggan-Keen, Margaret F; Stern, Peter L; Meijer, Chris J L M; Scheper, Rik J
Abstract:
T-helper (Th) cell-dependent IL-2 production and plasma IgG responses to virus-like particles consisting of the human papillomavirus type 16 (HPV-16) major capsid protein L1 (L1-VLP) were determined in patients with cytological evidence of cervical intraepithelial neoplasia (CIN) participating in a non-intervention prospective cohort study. IgG responses were associated with HPV-16 persistence and high-grade CIN lesions, while high frequencies of Th responses were observed in patients with both virus clearance and virus persistence, irrespective of CIN grade. The IgG response was found in conjunction with an IL-2 response to L1-VLP in 87% of the patients. Recognition of the HPV-16 L1 Th epitope (amino acids 311-335) was found to be more closely associated than recognition of L1-VLP as a whole to HPV exposure and CIN development. Among the HPV-16+ patients included in this study, those showing a Th response to amino acids 311-335 were more likely to carry the HLA DRB1*11/DQB1*0301 haplotype, while those showing an IgG response to L1-VLP were more likely to carry DRB1*0101/DQB1*0501. However, neither cell-mediated nor humoral immune responses against HPV-16 L1 appear to be sufficient for the natural control of HPV infection and CIN development.
Affiliation:
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.
Citation:
Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome. 1999, 80 ( Pt 2):399-408 J. Gen. Virol.
Journal:
Journal of General Virology
Issue Date:
Feb-1999
URI:
http://hdl.handle.net/10541/90761
PubMed ID:
10073700
Type:
Article
Language:
en
ISSN:
0022-1317
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDe Gruijl, Tanja Den
dc.contributor.authorBontkes, Hetty Jen
dc.contributor.authorWalboomers, Jan Men
dc.contributor.authorCoursaget, Pierreen
dc.contributor.authorStukart, Marij Jen
dc.contributor.authorDupuy, Catherineen
dc.contributor.authorKueter, Estheren
dc.contributor.authorVerheijen, René Hen
dc.contributor.authorHelmerhorst, Theo Jen
dc.contributor.authorDuggan-Keen, Margaret Fen
dc.contributor.authorStern, Peter Len
dc.contributor.authorMeijer, Chris J L Men
dc.contributor.authorScheper, Rik Jen
dc.date.accessioned2010-01-28T11:58:43Z-
dc.date.available2010-01-28T11:58:43Z-
dc.date.issued1999-02-
dc.identifier.citationImmune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome. 1999, 80 ( Pt 2):399-408 J. Gen. Virol.en
dc.identifier.issn0022-1317-
dc.identifier.pmid10073700-
dc.identifier.urihttp://hdl.handle.net/10541/90761-
dc.description.abstractT-helper (Th) cell-dependent IL-2 production and plasma IgG responses to virus-like particles consisting of the human papillomavirus type 16 (HPV-16) major capsid protein L1 (L1-VLP) were determined in patients with cytological evidence of cervical intraepithelial neoplasia (CIN) participating in a non-intervention prospective cohort study. IgG responses were associated with HPV-16 persistence and high-grade CIN lesions, while high frequencies of Th responses were observed in patients with both virus clearance and virus persistence, irrespective of CIN grade. The IgG response was found in conjunction with an IL-2 response to L1-VLP in 87% of the patients. Recognition of the HPV-16 L1 Th epitope (amino acids 311-335) was found to be more closely associated than recognition of L1-VLP as a whole to HPV exposure and CIN development. Among the HPV-16+ patients included in this study, those showing a Th response to amino acids 311-335 were more likely to carry the HLA DRB1*11/DQB1*0301 haplotype, while those showing an IgG response to L1-VLP were more likely to carry DRB1*0101/DQB1*0501. However, neither cell-mediated nor humoral immune responses against HPV-16 L1 appear to be sufficient for the natural control of HPV infection and CIN development.en
dc.language.isoenen
dc.subjectTumour Virus Infectionsen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult-
dc.subject.meshAmino Acid Sequence-
dc.subject.meshAntibodies, Viral-
dc.subject.meshAntigens, Viral-
dc.subject.meshCapsid Proteins-
dc.subject.meshCervical Intraepithelial Neoplasia-
dc.subject.meshCohort Studies-
dc.subject.meshEpitopes-
dc.subject.meshFemale-
dc.subject.meshGenotype-
dc.subject.meshHLA-DQ Antigens-
dc.subject.meshHLA-DR Antigens-
dc.subject.meshHaplotypes-
dc.subject.meshHumans-
dc.subject.meshImmunoglobulin G-
dc.subject.meshInterleukin-2-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshOncogene Proteins, Viral-
dc.subject.meshPapillomaviridae-
dc.subject.meshPapillomavirus Infections-
dc.subject.meshT-Lymphocytes, Helper-Inducer-
dc.subject.meshTumor Virus Infections-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleImmune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia. I. Differential T-helper and IgG responses in relation to HPV infection and disease outcome.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Free University Hospital, Amsterdam, The Netherlands.en
dc.identifier.journalJournal of General Virologyen

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