Herpesvirus papio encodes a functional homologue of the Epstein-Barr virus apoptosis suppressor, BHRF1.

2.50
Hdl Handle:
http://hdl.handle.net/10541/90141
Title:
Herpesvirus papio encodes a functional homologue of the Epstein-Barr virus apoptosis suppressor, BHRF1.
Authors:
Meseda, Clement A; Arrand, John R; Mackett, Mike
Abstract:
The human tumour virus Epstein-Barr virus (EBV) encodes a 17 kDa protein, BHRF1, which is a member of the BCL:-2 family and has been shown to suppress apoptosis. The role of this gene in the life-cycle of EBV has not been fully elucidated. In order to identify motifs conserved in herpesviruses and possibly shed light on its function we isolated a BHRF1 homologue from herpesvirus papio (cercopithecine herpesvirus-12) a closely related gammaherpesvirus of baboons. The gene, hvpBHRF1, also encodes a 17 kDa protein which shares 64% identity and 79% similarity with EBV BHRF1 at the amino acid level. In biological assays, hvpBHRF1 and BHRF1 conferred similar levels of protection on human keratinocytes induced to apoptose with cis-platin.
Affiliation:
Department of Molecular Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 9BX, UK.
Citation:
Herpesvirus papio encodes a functional homologue of the Epstein-Barr virus apoptosis suppressor, BHRF1. 2000, 81 (Pt 7):1801-5 J. Gen. Virol.
Journal:
The Journal of General Virology
Issue Date:
Jul-2000
URI:
http://hdl.handle.net/10541/90141
PubMed ID:
10859386
Type:
Article
Language:
en
ISSN:
0022-1317
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMeseda, Clement Aen
dc.contributor.authorArrand, John Ren
dc.contributor.authorMackett, Mikeen
dc.date.accessioned2010-01-20T15:11:03Z-
dc.date.available2010-01-20T15:11:03Z-
dc.date.issued2000-07-
dc.identifier.citationHerpesvirus papio encodes a functional homologue of the Epstein-Barr virus apoptosis suppressor, BHRF1. 2000, 81 (Pt 7):1801-5 J. Gen. Virol.en
dc.identifier.issn0022-1317-
dc.identifier.pmid10859386-
dc.identifier.urihttp://hdl.handle.net/10541/90141-
dc.description.abstractThe human tumour virus Epstein-Barr virus (EBV) encodes a 17 kDa protein, BHRF1, which is a member of the BCL:-2 family and has been shown to suppress apoptosis. The role of this gene in the life-cycle of EBV has not been fully elucidated. In order to identify motifs conserved in herpesviruses and possibly shed light on its function we isolated a BHRF1 homologue from herpesvirus papio (cercopithecine herpesvirus-12) a closely related gammaherpesvirus of baboons. The gene, hvpBHRF1, also encodes a 17 kDa protein which shares 64% identity and 79% similarity with EBV BHRF1 at the amino acid level. In biological assays, hvpBHRF1 and BHRF1 conferred similar levels of protection on human keratinocytes induced to apoptose with cis-platin.en
dc.language.isoenen
dc.subject.meshAmino Acid Sequence-
dc.subject.meshAnimals-
dc.subject.meshApoptosis-
dc.subject.meshHumans-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshOpen Reading Frames-
dc.subject.meshPapio-
dc.subject.meshProto-Oncogene Proteins c-bcl-2-
dc.subject.meshSequence Homology, Amino Acid-
dc.subject.meshSimplexvirus-
dc.subject.meshViral Proteins-
dc.titleHerpesvirus papio encodes a functional homologue of the Epstein-Barr virus apoptosis suppressor, BHRF1.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Biology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 9BX, UK.en
dc.identifier.journalThe Journal of General Virologyen

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