Immunohistochemical detection of steroid receptors in breast cancer: a working protocol.

2.50
Hdl Handle:
http://hdl.handle.net/10541/90075
Title:
Immunohistochemical detection of steroid receptors in breast cancer: a working protocol.
Authors:
Leake, Robin; Barnes, Diana M; Pinder, Sarah; Ellis, Ian; Anderson, Elizabeth; Anderson, Tom; Adamson, Ruth; Rhodes, Anthony; Miller, Keith D; Walker, Rosemary
Abstract:
The biochemical assay for the oestrogen receptor has shown the clinical value of knowing the concentration of the receptor within tissue. The immunohistochemical assay is rapidly taking over from the biochemical assay. Therefore, it is vital to have an equivalent scoring system that will have the same predictive value. This paper reports both a practical protocol and a scoring system that should achieve this aim. This approach should be applicable to many more biomarkers detected by immunohistochemistry.
Affiliation:
Department of Biochemistry and Molecular Biology, University of Glasgow, UK. R.Leake@bio.gla.ac.uk
Citation:
Immunohistochemical detection of steroid receptors in breast cancer: a working protocol. 2000, 53 (8):634-5 J. Clin. Pathol.
Journal:
Journal of Clinical Pathology
Issue Date:
Aug-2000
URI:
http://hdl.handle.net/10541/90075
DOI:
10.1136/jcp.53.8.634
PubMed ID:
11002770
Type:
Article
Language:
en
ISSN:
0021-9746
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLeake, Robinen
dc.contributor.authorBarnes, Diana Men
dc.contributor.authorPinder, Sarahen
dc.contributor.authorEllis, Ianen
dc.contributor.authorAnderson, Elizabethen
dc.contributor.authorAnderson, Tomen
dc.contributor.authorAdamson, Ruthen
dc.contributor.authorRhodes, Anthonyen
dc.contributor.authorMiller, Keith Den
dc.contributor.authorWalker, Rosemaryen
dc.date.accessioned2010-01-19T17:52:28Z-
dc.date.available2010-01-19T17:52:28Z-
dc.date.issued2000-08-
dc.identifier.citationImmunohistochemical detection of steroid receptors in breast cancer: a working protocol. 2000, 53 (8):634-5 J. Clin. Pathol.en
dc.identifier.issn0021-9746-
dc.identifier.pmid11002770-
dc.identifier.doi10.1136/jcp.53.8.634-
dc.identifier.urihttp://hdl.handle.net/10541/90075-
dc.description.abstractThe biochemical assay for the oestrogen receptor has shown the clinical value of knowing the concentration of the receptor within tissue. The immunohistochemical assay is rapidly taking over from the biochemical assay. Therefore, it is vital to have an equivalent scoring system that will have the same predictive value. This paper reports both a practical protocol and a scoring system that should achieve this aim. This approach should be applicable to many more biomarkers detected by immunohistochemistry.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectBiological Tumour Markersen
dc.subjectOestrogen Receptorsen
dc.subject.meshBreast Neoplasms-
dc.subject.meshChemotherapy, Adjuvant-
dc.subject.meshClinical Protocols-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshQuality Control-
dc.subject.meshReceptors, Estrogen-
dc.subject.meshTumor Markers, Biological-
dc.titleImmunohistochemical detection of steroid receptors in breast cancer: a working protocol.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biochemistry and Molecular Biology, University of Glasgow, UK. R.Leake@bio.gla.ac.uken
dc.identifier.journalJournal of Clinical Pathologyen
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