Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/90039
Title:
Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy.
Authors:
Morton, Colin A; Whitehurst, Colin; Moore, James V; MacKie, Rona M
Abstract:
BACKGROUND: A variety of protocols exist for the treatment of Bowen's disease by photodynamic therapy (PDT) using topical 5-aminolaevulinic acid (5-ALA). OBJECTIVE: To determine the optimal wavelength (red or green light) for this treatment. METHODS: A randomized comparison study of ALA-PDT using red (630 +/- 15 nm) or green (540 +/- 15 nm) light in the treatment of Bowen's disease. RESULTS: The initial clearance rate for lesions treated by red light was 94% (30 of 32) in comparison with 72% (21 of 29) for those lesions receiving green light (P = 0.002). Over the following 12 months, there were two recurrences in the red light group and seven in the green light group reducing the clearance rates to 88% and 48%, respectively. The frequency and severity of pain experienced were similar between the two treatment groups. No hyperthermia, nor significant difference in lesional temperatures, was observed between the wavelengths studied. CONCLUSION: Green light is less effective than red light, at a theoretically equivalent dose, in the treatment of Bowen's disease by topical ALA-PDT.
Affiliation:
University Department of Dermatology, Western Infirmary, Glasgow G11 6NT, UK. camorton@fdri2.fdri.scot.nhs.uk
Citation:
Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy. 2000, 143 (4):767-72 Br. J. Dermatol.
Journal:
The British Journal of Dermatology
Issue Date:
Oct-2000
URI:
http://hdl.handle.net/10541/90039
DOI:
10.1046/j.1365-2133.2000.03773.x
PubMed ID:
11069454
Type:
Article
Language:
en
ISSN:
0007-0963
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMorton, Colin Aen
dc.contributor.authorWhitehurst, Colinen
dc.contributor.authorMoore, James Ven
dc.contributor.authorMacKie, Rona Men
dc.date.accessioned2010-01-19T16:49:59Z-
dc.date.available2010-01-19T16:49:59Z-
dc.date.issued2000-10-
dc.identifier.citationComparison of red and green light in the treatment of Bowen's disease by photodynamic therapy. 2000, 143 (4):767-72 Br. J. Dermatol.en
dc.identifier.issn0007-0963-
dc.identifier.pmid11069454-
dc.identifier.doi10.1046/j.1365-2133.2000.03773.x-
dc.identifier.urihttp://hdl.handle.net/10541/90039-
dc.description.abstractBACKGROUND: A variety of protocols exist for the treatment of Bowen's disease by photodynamic therapy (PDT) using topical 5-aminolaevulinic acid (5-ALA). OBJECTIVE: To determine the optimal wavelength (red or green light) for this treatment. METHODS: A randomized comparison study of ALA-PDT using red (630 +/- 15 nm) or green (540 +/- 15 nm) light in the treatment of Bowen's disease. RESULTS: The initial clearance rate for lesions treated by red light was 94% (30 of 32) in comparison with 72% (21 of 29) for those lesions receiving green light (P = 0.002). Over the following 12 months, there were two recurrences in the red light group and seven in the green light group reducing the clearance rates to 88% and 48%, respectively. The frequency and severity of pain experienced were similar between the two treatment groups. No hyperthermia, nor significant difference in lesional temperatures, was observed between the wavelengths studied. CONCLUSION: Green light is less effective than red light, at a theoretically equivalent dose, in the treatment of Bowen's disease by topical ALA-PDT.en
dc.language.isoenen
dc.subjectCancer Recurrenceen
dc.subjectSkin Canceren
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAminolevulinic Acid-
dc.subject.meshBowen's Disease-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshPhotochemotherapy-
dc.subject.meshPhotosensitizing Agents-
dc.subject.meshSkin Neoplasms-
dc.titleComparison of red and green light in the treatment of Bowen's disease by photodynamic therapy.en
dc.typeArticleen
dc.contributor.departmentUniversity Department of Dermatology, Western Infirmary, Glasgow G11 6NT, UK. camorton@fdri2.fdri.scot.nhs.uken
dc.identifier.journalThe British Journal of Dermatologyen

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