2.50
Hdl Handle:
http://hdl.handle.net/10541/90036
Title:
The interaction of chalcones with tubulin.
Authors:
Lawrence, Nicholas J; McGown, Alan T; Ducki, Sylvie W; Hadfield, John A
Abstract:
The chalcone 3,4,3',4',5'-pentamethoxychalcone is a potent cytotoxic agent. A series of chalcones and (E)-4-(4'-hydroxyphenyl)but-3-en-2-one were prepared and assessed for their ability to inhibit cell growth in vitro. The cytotoxicity correlates with their ability to bind to tubulin as measured by immunofluorescence, cell cycle analysis and disruption of microtubule assembly. Some of the chalcones were shown to bind to the type II oestrogen receptor.
Affiliation:
Department of Chemistry, University of Manchester Institute of Science and Technology, UK. n.lawrence@umist.ac.uk
Citation:
The interaction of chalcones with tubulin. 2000, 15 (2):135-41 Anticancer Drug Des.
Journal:
Anti-Cancer Drug Design
Issue Date:
Apr-2000
URI:
http://hdl.handle.net/10541/90036
PubMed ID:
10901301
Type:
Article
Language:
en
ISSN:
0266-9536
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLawrence, Nicholas Jen
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorDucki, Sylvie Wen
dc.contributor.authorHadfield, John Aen
dc.date.accessioned2010-01-19T16:38:13Z-
dc.date.available2010-01-19T16:38:13Z-
dc.date.issued2000-04-
dc.identifier.citationThe interaction of chalcones with tubulin. 2000, 15 (2):135-41 Anticancer Drug Des.en
dc.identifier.issn0266-9536-
dc.identifier.pmid10901301-
dc.identifier.urihttp://hdl.handle.net/10541/90036-
dc.description.abstractThe chalcone 3,4,3',4',5'-pentamethoxychalcone is a potent cytotoxic agent. A series of chalcones and (E)-4-(4'-hydroxyphenyl)but-3-en-2-one were prepared and assessed for their ability to inhibit cell growth in vitro. The cytotoxicity correlates with their ability to bind to tubulin as measured by immunofluorescence, cell cycle analysis and disruption of microtubule assembly. Some of the chalcones were shown to bind to the type II oestrogen receptor.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshCell Cycle-
dc.subject.meshCell Division-
dc.subject.meshCell Survival-
dc.subject.meshCercopithecus aethiops-
dc.subject.meshChalcone-
dc.subject.meshDrug Design-
dc.subject.meshHumans-
dc.subject.meshIndicators and Reagents-
dc.subject.meshK562 Cells-
dc.subject.meshMicrotubules-
dc.subject.meshMolecular Structure-
dc.subject.meshPropiophenones-
dc.subject.meshStructure-Activity Relationship-
dc.subject.meshSwine-
dc.subject.meshTubulin-
dc.subject.meshVero Cells-
dc.titleThe interaction of chalcones with tubulin.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemistry, University of Manchester Institute of Science and Technology, UK. n.lawrence@umist.ac.uken
dc.identifier.journalAnti-Cancer Drug Designen

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