Epidemiology of herpesvirus papio infection in a large captive baboon colony: similarities to Epstein-Barr virus infection in humans.

2.50
Hdl Handle:
http://hdl.handle.net/10541/88621
Title:
Epidemiology of herpesvirus papio infection in a large captive baboon colony: similarities to Epstein-Barr virus infection in humans.
Authors:
Jenson, Hal B; Ench, Yasmin; Gao, Shou-Jiang; Rice, Karen; Carey, Dee; Kennedy, Ronald C; Arrand, John R; Mackett, Mike
Abstract:
The epidemiology of herpesvirus papio, a lymphocryptovirus similar to Epstein-Barr virus (EBV), was studied in a captive colony of >1900 baboons. Herpesvirus papio IgG antibody titers were measured by IFA. In total, 438 specimens from 296 baboons were assessed, including 116 serial specimens from 52 juveniles and 6 infants studied monthly for 1 year following birth and at age 18 months. Maternally derived antibody reached a nadir at 4 months of age. About 75% of animals at 12 months of age and >95% of animals after age 24 months demonstrated serologic evidence of herpesvirus papio infection. After age 3 years, the geometric mean titer was 1:60-75. The epidemiology of herpesvirus papio infection in baboons closely parallels that of EBV infection in humans. An animal model of lymphocryptovirus infection will facilitate investigations of human lymphocryptovirus biology.
Affiliation:
Departments of Pediatrics and Microbiology, University of Texas Health Science Center at San Antonio, 78229-3900, USA. jenson@uthscsa.edu
Citation:
Epidemiology of herpesvirus papio infection in a large captive baboon colony: similarities to Epstein-Barr virus infection in humans. 2000, 181 (4):1462-6 J. Infect. Dis.
Journal:
The Journal of Infectious Diseases
Issue Date:
Apr-2000
URI:
http://hdl.handle.net/10541/88621
DOI:
10.1086/315385
PubMed ID:
10762578
Type:
Article
Language:
en
ISSN:
0022-1899
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorJenson, Hal Ben
dc.contributor.authorEnch, Yasminen
dc.contributor.authorGao, Shou-Jiangen
dc.contributor.authorRice, Karenen
dc.contributor.authorCarey, Deeen
dc.contributor.authorKennedy, Ronald Cen
dc.contributor.authorArrand, John Ren
dc.contributor.authorMackett, Mikeen
dc.date.accessioned2009-12-29T10:46:03Z-
dc.date.available2009-12-29T10:46:03Z-
dc.date.issued2000-04-
dc.identifier.citationEpidemiology of herpesvirus papio infection in a large captive baboon colony: similarities to Epstein-Barr virus infection in humans. 2000, 181 (4):1462-6 J. Infect. Dis.en
dc.identifier.issn0022-1899-
dc.identifier.pmid10762578-
dc.identifier.doi10.1086/315385-
dc.identifier.urihttp://hdl.handle.net/10541/88621-
dc.description.abstractThe epidemiology of herpesvirus papio, a lymphocryptovirus similar to Epstein-Barr virus (EBV), was studied in a captive colony of >1900 baboons. Herpesvirus papio IgG antibody titers were measured by IFA. In total, 438 specimens from 296 baboons were assessed, including 116 serial specimens from 52 juveniles and 6 infants studied monthly for 1 year following birth and at age 18 months. Maternally derived antibody reached a nadir at 4 months of age. About 75% of animals at 12 months of age and >95% of animals after age 24 months demonstrated serologic evidence of herpesvirus papio infection. After age 3 years, the geometric mean titer was 1:60-75. The epidemiology of herpesvirus papio infection in baboons closely parallels that of EBV infection in humans. An animal model of lymphocryptovirus infection will facilitate investigations of human lymphocryptovirus biology.en
dc.language.isoenen
dc.subjectSocial Behaviouren
dc.subject.meshAnimals-
dc.subject.meshAntibodies, Viral-
dc.subject.meshDisease Transmission, Infectious-
dc.subject.meshEpstein-Barr Virus Infections-
dc.subject.meshFemale-
dc.subject.meshHerpesviridae Infections-
dc.subject.meshHumans-
dc.subject.meshInfectious Disease Transmission, Vertical-
dc.subject.meshMale-
dc.subject.meshMonkey Diseases-
dc.subject.meshPapio-
dc.subject.meshSeroepidemiologic Studies-
dc.subject.meshSocial Behavior-
dc.titleEpidemiology of herpesvirus papio infection in a large captive baboon colony: similarities to Epstein-Barr virus infection in humans.en
dc.typeArticleen
dc.contributor.departmentDepartments of Pediatrics and Microbiology, University of Texas Health Science Center at San Antonio, 78229-3900, USA. jenson@uthscsa.eduen
dc.identifier.journalThe Journal of Infectious Diseasesen

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