Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones.

2.50
Hdl Handle:
http://hdl.handle.net/10541/88618
Title:
Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones.
Authors:
Hargreaves, Robert H J; Hartley, John A; Butler, John
Abstract:
Aziridinyl quinones can be activated by cellular reductases eg. DT-diaphorase and cytochrome P450 reductase to form highly reactive DNA alkylating agents. The mechanisms by which this activation and alkylation take place are many and varied. Using clinically relevant and experimental agents this review will describe many of these mechanisms. The agents discussed are Mitomycin C, EO9 and analogues, diaziridinylbenzoquinones and the pyrrolo[1, 2-alpha]benzimidazolequinones.
Affiliation:
CRC Drug Development Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, U.K.
Citation:
Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones. 2000, 5:E172-80 Front. Biosci.
Journal:
Frontiers in Bioscience
Issue Date:
1-Nov-2000
URI:
http://hdl.handle.net/10541/88618
PubMed ID:
11056081
Type:
Article
Language:
en
ISSN:
1093-4715
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHargreaves, Robert H Jen
dc.contributor.authorHartley, John Aen
dc.contributor.authorButler, Johnen
dc.date.accessioned2009-12-29T10:41:07Z-
dc.date.available2009-12-29T10:41:07Z-
dc.date.issued2000-11-01-
dc.identifier.citationMechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones. 2000, 5:E172-80 Front. Biosci.en
dc.identifier.issn1093-4715-
dc.identifier.pmid11056081-
dc.identifier.urihttp://hdl.handle.net/10541/88618-
dc.description.abstractAziridinyl quinones can be activated by cellular reductases eg. DT-diaphorase and cytochrome P450 reductase to form highly reactive DNA alkylating agents. The mechanisms by which this activation and alkylation take place are many and varied. Using clinically relevant and experimental agents this review will describe many of these mechanisms. The agents discussed are Mitomycin C, EO9 and analogues, diaziridinylbenzoquinones and the pyrrolo[1, 2-alpha]benzimidazolequinones.en
dc.language.isoenen
dc.subject.meshAlkylation-
dc.subject.meshAntineoplastic Agents, Alkylating-
dc.subject.meshAziridines-
dc.subject.meshBenzimidazoles-
dc.subject.meshBenzoquinones-
dc.subject.meshCarbazilquinone-
dc.subject.meshDNA-
dc.subject.meshDoxorubicin-
dc.subject.meshHumans-
dc.subject.meshIndolequinones-
dc.subject.meshIndoles-
dc.subject.meshMitomycin-
dc.subject.meshMolecular Structure-
dc.subject.meshOxidation-Reduction-
dc.subject.meshQuinones-
dc.subject.meshStructure-Activity Relationship-
dc.titleMechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones.en
dc.typeArticleen
dc.contributor.departmentCRC Drug Development Group, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, U.K.en
dc.identifier.journalFrontiers in Bioscienceen
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