Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/88053
Title:
Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma.
Authors:
Attwooll, Claire L; Tariq, M; Harris, Martin; Coyne, J D; Telford, Nicholas; Varley, Jennifer
Abstract:
A proportion of extraskeletal myxoid chondrosarcomas (EMC) have been shown to have a characteristic translocation t(9;22)(q22;q12) involving the EWS gene at 22q12 and the CHN orphan nuclear receptor gene at 9q22. This translocation appears to be largely specific for EMC, but has not been detected in all such tumours. We report here a case of EMC with a t(9;17)(q22;q11.2) as the sole chromosome abnormality. We have determined that the translocation results in the fusion of the entire coding region of CHN to the N-terminal transactivation domain of RBP56/hTAFII68. This is the first report of a translocation involving RBP56/hTAFII 68, a protein with sequence homology to both EWS and TLS/FUS. The involvement of RBP56/hTAFII68 may explain some unusual features of the tumour.
Affiliation:
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, UK.
Citation:
Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma. 1999, 18 (52):7599-601 Oncogene
Journal:
Oncogene
Issue Date:
9-Dec-1999
URI:
http://hdl.handle.net/10541/88053
DOI:
10.1038/sj.onc.1203156
PubMed ID:
10602520
Type:
Article
Language:
en
ISSN:
0950-9232
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorAttwooll, Claire Len
dc.contributor.authorTariq, Men
dc.contributor.authorHarris, Martinen
dc.contributor.authorCoyne, J Den
dc.contributor.authorTelford, Nicholasen
dc.contributor.authorVarley, Jenniferen
dc.date.accessioned2009-12-15T16:30:47Z-
dc.date.available2009-12-15T16:30:47Z-
dc.date.issued1999-12-09-
dc.identifier.citationIdentification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma. 1999, 18 (52):7599-601 Oncogeneen
dc.identifier.issn0950-9232-
dc.identifier.pmid10602520-
dc.identifier.doi10.1038/sj.onc.1203156-
dc.identifier.urihttp://hdl.handle.net/10541/88053-
dc.description.abstractA proportion of extraskeletal myxoid chondrosarcomas (EMC) have been shown to have a characteristic translocation t(9;22)(q22;q12) involving the EWS gene at 22q12 and the CHN orphan nuclear receptor gene at 9q22. This translocation appears to be largely specific for EMC, but has not been detected in all such tumours. We report here a case of EMC with a t(9;17)(q22;q11.2) as the sole chromosome abnormality. We have determined that the translocation results in the fusion of the entire coding region of CHN to the N-terminal transactivation domain of RBP56/hTAFII68. This is the first report of a translocation involving RBP56/hTAFII 68, a protein with sequence homology to both EWS and TLS/FUS. The involvement of RBP56/hTAFII68 may explain some unusual features of the tumour.en
dc.language.isoenen
dc.subject.meshAmino Acid Sequence-
dc.subject.meshArtificial Gene Fusion-
dc.subject.meshBase Sequence-
dc.subject.meshChondrosarcoma-
dc.subject.meshChromosomes, Human, Pair 17-
dc.subject.meshChromosomes, Human, Pair 9-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshHumans-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshNerve Tissue Proteins-
dc.subject.meshNuclear Proteins-
dc.subject.meshReceptors, Steroid-
dc.subject.meshReceptors, Thyroid Hormone-
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction-
dc.subject.meshTATA-Binding Protein Associated Factors-
dc.subject.meshTranscription Factors-
dc.subject.meshTranslocation, Genetic-
dc.titleIdentification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, UK.en
dc.identifier.journalOncogeneen

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