Routine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/88047
Title:
Routine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy.
Authors:
Haller, J C; Cairnduff, F; Slack, G; Schofield, J; Whitehurst, Colin; Tunstall, R; Brown, S B; Roberts, D J
Abstract:
BACKGROUND: Superficial basal cell carcinomas of the skin (sBCC) often respond poorly to single-treatment aminolaevulinic acid-based photodynamic therapy (ALA-PDT), with a number of reports indicating a relapse rate of 50% or more. OBJECTIVES: To determine whether a second treatment at seven days can improve the response. METHODS: Twenty-six lesions were treated twice with ALA-PDT, with an interval of 7 days between the two treatment sessions. RESULTS: We observed a complete response rate of 100% 1 month after treatment. Only one lesion relapsed (16 months post-PDT), a relapse rate of 4% (median follow up 27 months; range 15-45 months). Cosmetic results were excellent. CONCLUSIONS: We consider routine double treatments with ALA-PDT to be an effective approach to the management of sBCC, particularly those located in anatomically difficult, or cosmetically sensitive, sites.
Affiliation:
School of Medicine, Department of Colour Chemistry, Schools of Biomedical Sciences, and Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, U.K.
Citation:
Routine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy. 2000, 143 (6):1270-5 Br. J. Dermatol.
Journal:
British Journal of Dermatology
Issue Date:
Dec-2000
URI:
http://hdl.handle.net/10541/88047
DOI:
10.1046/j.1365-2133.2000.04000.x
PubMed ID:
11122032
Type:
Article
Language:
en
ISSN:
0007-0963
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHaller, J Cen
dc.contributor.authorCairnduff, Fen
dc.contributor.authorSlack, Gen
dc.contributor.authorSchofield, Jen
dc.contributor.authorWhitehurst, Colinen
dc.contributor.authorTunstall, Ren
dc.contributor.authorBrown, S Ben
dc.contributor.authorRoberts, D Jen
dc.date.accessioned2009-12-15T17:24:11Z-
dc.date.available2009-12-15T17:24:11Z-
dc.date.issued2000-12-
dc.identifier.citationRoutine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy. 2000, 143 (6):1270-5 Br. J. Dermatol.en
dc.identifier.issn0007-0963-
dc.identifier.pmid11122032-
dc.identifier.doi10.1046/j.1365-2133.2000.04000.x-
dc.identifier.urihttp://hdl.handle.net/10541/88047-
dc.description.abstractBACKGROUND: Superficial basal cell carcinomas of the skin (sBCC) often respond poorly to single-treatment aminolaevulinic acid-based photodynamic therapy (ALA-PDT), with a number of reports indicating a relapse rate of 50% or more. OBJECTIVES: To determine whether a second treatment at seven days can improve the response. METHODS: Twenty-six lesions were treated twice with ALA-PDT, with an interval of 7 days between the two treatment sessions. RESULTS: We observed a complete response rate of 100% 1 month after treatment. Only one lesion relapsed (16 months post-PDT), a relapse rate of 4% (median follow up 27 months; range 15-45 months). Cosmetic results were excellent. CONCLUSIONS: We consider routine double treatments with ALA-PDT to be an effective approach to the management of sBCC, particularly those located in anatomically difficult, or cosmetically sensitive, sites.en
dc.language.isoenen
dc.subjectSkin Canceren
dc.subject.meshAdministration, Cutaneous-
dc.subject.meshAged-
dc.subject.meshAminolevulinic Acid-
dc.subject.meshCarcinoma, Basal Cell-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshLidocaine-
dc.subject.meshMale-
dc.subject.meshMicroscopy, Fluorescence-
dc.subject.meshMiddle Aged-
dc.subject.meshOintments-
dc.subject.meshPhotochemotherapy-
dc.subject.meshPhotosensitizing Agents-
dc.subject.meshPrilocaine-
dc.subject.meshSkin Neoplasms-
dc.titleRoutine double treatments of superficial basal cell carcinomas using aminolaevulinic acid-based photodynamic therapy.en
dc.typeArticleen
dc.contributor.departmentSchool of Medicine, Department of Colour Chemistry, Schools of Biomedical Sciences, and Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, U.K.en
dc.identifier.journalBritish Journal of Dermatologyen
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