Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay.

2.50
Hdl Handle:
http://hdl.handle.net/10541/88043
Title:
Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay.
Authors:
Burrill, Wayne; Barber, James B P; Roberts, Stephen A; Bulman, Barbara; Scott, David
Abstract:
Of breast cancer patients, 30% are sensitive in a lymphocyte assay of radiation-induced chromosome damage (micronucleus induction) compared with 10% of healthy controls. Twenty-two first-degree relatives of 11 sensitive patients had an average micronucleus yield significantly higher than that of 68 controls. This suggests that radiosensitivity in this assay may be an inherited characteristic associated with predisposition to breast cancer.
Affiliation:
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK.
Citation:
Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay. 2000, 76 (12):1617-9 Int. J. Radiat. Biol.
Journal:
International Journal of Radiation Biology
Issue Date:
Dec-2000
URI:
http://hdl.handle.net/10541/88043
DOI:
10.1080/09553000050201109
PubMed ID:
11133043
Type:
Article
Language:
en
ISSN:
0955-3002
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBurrill, Wayneen
dc.contributor.authorBarber, James B Pen
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorBulman, Barbaraen
dc.contributor.authorScott, Daviden
dc.date.accessioned2009-12-15T16:55:26Z-
dc.date.available2009-12-15T16:55:26Z-
dc.date.issued2000-12-
dc.identifier.citationHeritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay. 2000, 76 (12):1617-9 Int. J. Radiat. Biol.en
dc.identifier.issn0955-3002-
dc.identifier.pmid11133043-
dc.identifier.doi10.1080/09553000050201109-
dc.identifier.urihttp://hdl.handle.net/10541/88043-
dc.description.abstractOf breast cancer patients, 30% are sensitive in a lymphocyte assay of radiation-induced chromosome damage (micronucleus induction) compared with 10% of healthy controls. Twenty-two first-degree relatives of 11 sensitive patients had an average micronucleus yield significantly higher than that of 68 controls. This suggests that radiosensitivity in this assay may be an inherited characteristic associated with predisposition to breast cancer.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshBreast Neoplasms-
dc.subject.meshCase-Control Studies-
dc.subject.meshChromosomes-
dc.subject.meshFamily Health-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshHumans-
dc.subject.meshLymphocytes-
dc.subject.meshMale-
dc.subject.meshMicronucleus Tests-
dc.subject.meshPilot Projects-
dc.titleHeritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Withington, Manchester, UK.en
dc.identifier.journalInternational Journal of Radiation Biologyen

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