Prognostic relevance of micro-vessel density in cancer of the urinary bladder.

2.50
Hdl Handle:
http://hdl.handle.net/10541/88027
Title:
Prognostic relevance of micro-vessel density in cancer of the urinary bladder.
Authors:
Chaudhary, R; Bromley, Michael; Clarke, Noel W ( 0000-0001-7776-8059 ) ; Betts, C D; Barnard, R J; Ryder, W David J; Kumar, Shant
Abstract:
Angiogenesis is an important factor in tumour growth and metastasis. Degree of angiogenesis (microvascular density-MVD) has been found to correlate with tumour progression and disease outcome in a number of different malignancies. We studied 88 patients undergoing cystectomy for transitional cell bladder cancer to determine if angiogenesis was associated with cancer specific survival. Microvessels were identified by immunostaining of endothelial cells for CD31. Active areas of angiogenesis ("hot spots") were selected using low magnification. The vessel count was performed using a Chalkley point graticule. The mean of 3 counts was used for statistical analysis. The median count was 3.4. Univariate analysis revealed that higher MVD was associated with worsening prognosis (p = 0.02). When adjusted for clinical stage MVD continued to predict worsening prognosis (p = 0.02). MVD was not affected by age or sex or by previous radiotherapy. MVD was associated with the risk of patients dying following pelvic recurrence (p = 0.03) and MVD was significantly higher in patients with lymph node metastasis at surgery. In conclusion, microvessel density proved to be an independent prognostic marker in transitional cell carcinoma of bladder.
Affiliation:
Christie Hospital, Manchester, U.K.
Citation:
Prognostic relevance of micro-vessel density in cancer of the urinary bladder., 19 (4C):3479-84 Anticancer Res.
Journal:
Anticancer Research
Issue Date:
1999
URI:
http://hdl.handle.net/10541/88027
PubMed ID:
10629639
Type:
Article
Language:
en
ISSN:
0250-7005
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorChaudhary, Ren
dc.contributor.authorBromley, Michaelen
dc.contributor.authorClarke, Noel Wen
dc.contributor.authorBetts, C Den
dc.contributor.authorBarnard, R Jen
dc.contributor.authorRyder, W David Jen
dc.contributor.authorKumar, Shanten
dc.date.accessioned2009-12-15T16:03:58Z-
dc.date.available2009-12-15T16:03:58Z-
dc.date.issued1999-
dc.identifier.citationPrognostic relevance of micro-vessel density in cancer of the urinary bladder., 19 (4C):3479-84 Anticancer Res.en
dc.identifier.issn0250-7005-
dc.identifier.pmid10629639-
dc.identifier.urihttp://hdl.handle.net/10541/88027-
dc.description.abstractAngiogenesis is an important factor in tumour growth and metastasis. Degree of angiogenesis (microvascular density-MVD) has been found to correlate with tumour progression and disease outcome in a number of different malignancies. We studied 88 patients undergoing cystectomy for transitional cell bladder cancer to determine if angiogenesis was associated with cancer specific survival. Microvessels were identified by immunostaining of endothelial cells for CD31. Active areas of angiogenesis ("hot spots") were selected using low magnification. The vessel count was performed using a Chalkley point graticule. The mean of 3 counts was used for statistical analysis. The median count was 3.4. Univariate analysis revealed that higher MVD was associated with worsening prognosis (p = 0.02). When adjusted for clinical stage MVD continued to predict worsening prognosis (p = 0.02). MVD was not affected by age or sex or by previous radiotherapy. MVD was associated with the risk of patients dying following pelvic recurrence (p = 0.03) and MVD was significantly higher in patients with lymph node metastasis at surgery. In conclusion, microvessel density proved to be an independent prognostic marker in transitional cell carcinoma of bladder.en
dc.language.isoenen
dc.subjectUrinary Bladder Canceren
dc.subject.meshAdult-
dc.subject.meshAge Factors-
dc.subject.meshAged-
dc.subject.meshCarcinoma, Transitional Cell-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshImmunoenzyme Techniques-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeovascularization, Pathologic-
dc.subject.meshPrognosis-
dc.subject.meshTime Factors-
dc.subject.meshUrinary Bladder Neoplasms-
dc.titlePrognostic relevance of micro-vessel density in cancer of the urinary bladder.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital, Manchester, U.K.en
dc.identifier.journalAnticancer Researchen

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