Paradoxical expression of E-cadherin in prostatic bone metastases.

2.50
Hdl Handle:
http://hdl.handle.net/10541/88024
Title:
Paradoxical expression of E-cadherin in prostatic bone metastases.
Authors:
Bryden, A A; Freemont, Anthony J; Clarke, Noel W ( 0000-0001-7776-8059 ) ; George, Nicholas J
Abstract:
OBJECTIVE: To determine whether the calcium-dependent cell adhesion molecule E-cadherin is expressed in metastatic deposits of prostate cancer in bone. PATIENTS AND METHODS: Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were obtained and immunohistochemically stained for E-cadherin with the monoclonal antibody HECD-1, using the streptavidin-biotin complex technique. Benign prostatic tissue was used as the control. RESULTS: Of the 10 specimens, nine showed positive expression of E-cadherin, graded as strong in four. E-cadherin expression was strongest in well-differentiated metastases and decreased with increasing tumour grade. In some specimens there were mixed patterns of expression. CONCLUSION: E-cadherin is strongly expressed in prostatic bone metastases and the degree of expression appears to reflect local tumour grade. This suggests that loss of E-cadherin expression may not be critically linked to metastatic potential.
Affiliation:
Department of Urology, University Hospital of South Manchester, UK.
Citation:
Paradoxical expression of E-cadherin in prostatic bone metastases. 1999, 84 (9):1032-4 BJU Int.
Journal:
BJU International
Issue Date:
Dec-1999
URI:
http://hdl.handle.net/10541/88024
DOI:
10.1046/j.1464-410x.1999.00378.x
PubMed ID:
10571629
Type:
Article
Language:
en
ISSN:
1464-4096
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBryden, A Aen
dc.contributor.authorFreemont, Anthony Jen
dc.contributor.authorClarke, Noel Wen
dc.contributor.authorGeorge, Nicholas Jen
dc.date.accessioned2009-12-15T15:58:07Z-
dc.date.available2009-12-15T15:58:07Z-
dc.date.issued1999-12-
dc.identifier.citationParadoxical expression of E-cadherin in prostatic bone metastases. 1999, 84 (9):1032-4 BJU Int.en
dc.identifier.issn1464-4096-
dc.identifier.pmid10571629-
dc.identifier.doi10.1046/j.1464-410x.1999.00378.x-
dc.identifier.urihttp://hdl.handle.net/10541/88024-
dc.description.abstractOBJECTIVE: To determine whether the calcium-dependent cell adhesion molecule E-cadherin is expressed in metastatic deposits of prostate cancer in bone. PATIENTS AND METHODS: Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were obtained and immunohistochemically stained for E-cadherin with the monoclonal antibody HECD-1, using the streptavidin-biotin complex technique. Benign prostatic tissue was used as the control. RESULTS: Of the 10 specimens, nine showed positive expression of E-cadherin, graded as strong in four. E-cadherin expression was strongest in well-differentiated metastases and decreased with increasing tumour grade. In some specimens there were mixed patterns of expression. CONCLUSION: E-cadherin is strongly expressed in prostatic bone metastases and the degree of expression appears to reflect local tumour grade. This suggests that loss of E-cadherin expression may not be critically linked to metastatic potential.en
dc.language.isoenen
dc.subjectBone Canceren
dc.subjectProstatic Canceren
dc.subject.meshBiopsy-
dc.subject.meshBone Neoplasms-
dc.subject.meshCadherins-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMale-
dc.subject.meshProstatic Neoplasms-
dc.titleParadoxical expression of E-cadherin in prostatic bone metastases.en
dc.typeArticleen
dc.contributor.departmentDepartment of Urology, University Hospital of South Manchester, UK.en
dc.identifier.journalBJU Internationalen

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