Outcome of radiotherapy after breast conserving surgery in screen detected breast cancers.

2.50
Hdl Handle:
http://hdl.handle.net/10541/88019
Title:
Outcome of radiotherapy after breast conserving surgery in screen detected breast cancers.
Authors:
Magee, Brian; Stewart, Alan L; Swindell, Ric
Abstract:
The treatment outcomes were reviewed for all the patients at this institute who underwent breast irradiation after breast conserving surgery in 1991. Of a total of 643 patients treated, 194 (30%) had presented with tumours detected by screening mammography. The breast was irradiated with a tangential pair of fields, giving a dose of 40 Gy in 15 fractions over 3 weeks in 97% of these patients. A boost was not used. With a median follow-up of 4.7 years, there was better cancer related survival in patients with screen detected cancers compared with those that were non-screen detected (94% versus 84% at 5 years; P = 0.002). The breast recurrence rate at 5 years was 1% for screen detected cancers compared with 6% for those that were non-screen detected (P = 0.01). Factors additional to screen detected status that were found to be significant for cancer survival were pathological stage (P = 0.03) and histological grade (P = 0.01). In a Cox multivariate analysis, only two factors were significant for breast recurrence: screen detected status (P = 0.023) and histological grade (P = 0.016). This study suggests that breast irradiation with 40 Gy given over 3 weeks after breast conserving surgery for screen detected breast cancer gives a high level of local control out to 5 years.
Affiliation:
Christie Hospital, Manchester, UK.
Citation:
Outcome of radiotherapy after breast conserving surgery in screen detected breast cancers. 1999, 11 (1):40-5 Clin Oncol
Journal:
Clinical Oncology
Issue Date:
1999
URI:
http://hdl.handle.net/10541/88019
DOI:
10.1053/clon.1999.9007
PubMed ID:
10194585
Type:
Article
Language:
en
ISSN:
0936-6555
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMagee, Brianen
dc.contributor.authorStewart, Alan Len
dc.contributor.authorSwindell, Ricen
dc.date.accessioned2009-12-15T15:54:44Z-
dc.date.available2009-12-15T15:54:44Z-
dc.date.issued1999-
dc.identifier.citationOutcome of radiotherapy after breast conserving surgery in screen detected breast cancers. 1999, 11 (1):40-5 Clin Oncolen
dc.identifier.issn0936-6555-
dc.identifier.pmid10194585-
dc.identifier.doi10.1053/clon.1999.9007-
dc.identifier.urihttp://hdl.handle.net/10541/88019-
dc.description.abstractThe treatment outcomes were reviewed for all the patients at this institute who underwent breast irradiation after breast conserving surgery in 1991. Of a total of 643 patients treated, 194 (30%) had presented with tumours detected by screening mammography. The breast was irradiated with a tangential pair of fields, giving a dose of 40 Gy in 15 fractions over 3 weeks in 97% of these patients. A boost was not used. With a median follow-up of 4.7 years, there was better cancer related survival in patients with screen detected cancers compared with those that were non-screen detected (94% versus 84% at 5 years; P = 0.002). The breast recurrence rate at 5 years was 1% for screen detected cancers compared with 6% for those that were non-screen detected (P = 0.01). Factors additional to screen detected status that were found to be significant for cancer survival were pathological stage (P = 0.03) and histological grade (P = 0.01). In a Cox multivariate analysis, only two factors were significant for breast recurrence: screen detected status (P = 0.023) and histological grade (P = 0.016). This study suggests that breast irradiation with 40 Gy given over 3 weeks after breast conserving surgery for screen detected breast cancer gives a high level of local control out to 5 years.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshAged-
dc.subject.meshAntineoplastic Agents, Hormonal-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma, Ductal, Breast-
dc.subject.meshCarcinoma, Lobular-
dc.subject.meshChemotherapy, Adjuvant-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshMammography-
dc.subject.meshMass Screening-
dc.subject.meshMastectomy, Segmental-
dc.subject.meshMiddle Aged-
dc.subject.meshMultivariate Analysis-
dc.subject.meshProspective Studies-
dc.subject.meshRadiation Dosage-
dc.subject.meshRadiotherapy, Adjuvant-
dc.subject.meshSurvival Analysis-
dc.subject.meshTamoxifen-
dc.subject.meshTreatment Outcome-
dc.titleOutcome of radiotherapy after breast conserving surgery in screen detected breast cancers.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital, Manchester, UK.en
dc.identifier.journalClinical Oncologyen

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