Leptin binding activity changes with age: the link between leptin and puberty.

2.50
Hdl Handle:
http://hdl.handle.net/10541/88013
Title:
Leptin binding activity changes with age: the link between leptin and puberty.
Authors:
Quinton, N D; Smith, R F; Clayton, Peter E; Gill, M S; Shalet, Stephen M; Justice, S K; Simon, S A; Walters, S; Postel-Vinay, M C; Blakemore, A I; Ross, R J
Abstract:
The timing of the physical transition from child to adult is determined by a biological clock that switches off the pituitary gonadal axis during infancy until puberty. Body composition (and in particular, fat mass), through leptin, are critical signals to this clock. However, no direct relationship between leptin and puberty has been demonstrated. Leptin is bound in the circulation by a high-affinity binding protein, which has been identified as a soluble leptin receptor. We found circulating levels of leptin binding activity (LBA) to be low at birth, to be high in the prepubertal years, to fall through puberty, and then to remain stable during adult life. LBA correlated with pubertal status in both boys and girls. We postulate that the fall in LBA, associated with increasing age and puberty, reflects a reduction in expression of truncated leptin receptors, and leptin is then available to the full-length receptor, which transmits the biological signal for leptin. The high levels of LBA occur during the years when the pituitary gonadal axis is quiescent. Thus, the change in LBA could explain how leptin regulates puberty.
Affiliation:
The Division of Clinical Sciences, Sheffield University, Biomedical Research Centre, Sheffield Hallam University, United Kingdom.
Citation:
Leptin binding activity changes with age: the link between leptin and puberty. 1999, 84 (7):2336-41 J. Clin. Endocrinol. Metab.
Journal:
The Journal of Clinical Endocrinology and Metabolism
Issue Date:
Jul-1999
URI:
http://hdl.handle.net/10541/88013
DOI:
10.1210/jc.84.7.2336
PubMed ID:
10404799
Type:
Article
Language:
en
ISSN:
0021-972X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorQuinton, N Den
dc.contributor.authorSmith, R Fen
dc.contributor.authorClayton, Peter Een
dc.contributor.authorGill, M Sen
dc.contributor.authorShalet, Stephen Men
dc.contributor.authorJustice, S Ken
dc.contributor.authorSimon, S Aen
dc.contributor.authorWalters, Sen
dc.contributor.authorPostel-Vinay, M Cen
dc.contributor.authorBlakemore, A Ien
dc.contributor.authorRoss, R Jen
dc.date.accessioned2009-12-15T14:55:23Z-
dc.date.available2009-12-15T14:55:23Z-
dc.date.issued1999-07-
dc.identifier.citationLeptin binding activity changes with age: the link between leptin and puberty. 1999, 84 (7):2336-41 J. Clin. Endocrinol. Metab.en
dc.identifier.issn0021-972X-
dc.identifier.pmid10404799-
dc.identifier.doi10.1210/jc.84.7.2336-
dc.identifier.urihttp://hdl.handle.net/10541/88013-
dc.description.abstractThe timing of the physical transition from child to adult is determined by a biological clock that switches off the pituitary gonadal axis during infancy until puberty. Body composition (and in particular, fat mass), through leptin, are critical signals to this clock. However, no direct relationship between leptin and puberty has been demonstrated. Leptin is bound in the circulation by a high-affinity binding protein, which has been identified as a soluble leptin receptor. We found circulating levels of leptin binding activity (LBA) to be low at birth, to be high in the prepubertal years, to fall through puberty, and then to remain stable during adult life. LBA correlated with pubertal status in both boys and girls. We postulate that the fall in LBA, associated with increasing age and puberty, reflects a reduction in expression of truncated leptin receptors, and leptin is then available to the full-length receptor, which transmits the biological signal for leptin. The high levels of LBA occur during the years when the pituitary gonadal axis is quiescent. Thus, the change in LBA could explain how leptin regulates puberty.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAging-
dc.subject.meshBinding, Competitive-
dc.subject.meshBody Mass Index-
dc.subject.meshCarrier Proteins-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshChromatography, High Pressure Liquid-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshLeptin-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshProtein Binding-
dc.subject.meshProteins-
dc.subject.meshPuberty-
dc.subject.meshReceptors, Cell Surface-
dc.subject.meshReceptors, Leptin-
dc.subject.meshTestis-
dc.titleLeptin binding activity changes with age: the link between leptin and puberty.en
dc.typeArticleen
dc.contributor.departmentThe Division of Clinical Sciences, Sheffield University, Biomedical Research Centre, Sheffield Hallam University, United Kingdom.en
dc.identifier.journalThe Journal of Clinical Endocrinology and Metabolismen

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