Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast.

2.50
Hdl Handle:
http://hdl.handle.net/10541/88011
Title:
Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast.
Authors:
Hargreaves, Danielle F; Potten, Christopher S; Harding, Claudia; Shaw, Lesley E; Morton, Michael S; Roberts, Stephen A; Howell, Anthony ( 0000-0002-3879-5991 ) ; Bundred, Nigel J
Abstract:
An association has been reported between consumption of a high soy diet and a low incidence of breast cancer within populations of Southeast Asia. Phytoestrogens present in soy act as partial estrogen agonists or antagonists and can inhibit breast cancer cell proliferation in vitro. The effect of 14-day dietary soy supplementation with 60 g (45 mg isoflavones) on the normal breast of 84 premenopausal patients was determined. Serum concentrations of the isoflavanoids, genistein, daidzein, and equol, were raised in patients after soy supplementation (P < or = 0.025). Nipple aspirate (NA) levels of genistein and daidzein were higher than paired serum levels, both before (P < 0.001 and P = 0.001, respectively) and after soy supplementation (P < 0.001 and P = 0.049, respectively); however, there was no significant increase in NA isoflavone levels in response to soy. NA levels of apolipoprotein D were significantly lowered and pS2 levels raised in response to soy supplementation (P < or = 0.002), indicative of an estrogenic stimulus. No effect of soy supplementation on breast epithelial cell proliferation, estrogen and progesterone receptor status, apoptosis, mitosis, or Bcl-2 expression was detected. In conclusion, short term dietary soy has a weak estrogenic response on the breast, as measured by nipple aspirate apolipoprotein D and pS2 expression. No antiestrogenic effect of soy on the breast was detected.
Affiliation:
Epithelial Biology Group, Paterson Institute for Cancer Research.
Citation:
Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast. 1999, 84 (11):4017-24 J. Clin. Endocrinol. Metab.
Journal:
The Journal of Clinical Endocrinology and Metabolism
Issue Date:
Nov-1999
URI:
http://hdl.handle.net/10541/88011
DOI:
10.1210/jc.84.11.4017
PubMed ID:
10566643
Type:
Article
Language:
en
ISSN:
0021-972X
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHargreaves, Danielle Fen
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorHarding, Claudiaen
dc.contributor.authorShaw, Lesley Een
dc.contributor.authorMorton, Michael Sen
dc.contributor.authorRoberts, Stephen Aen
dc.contributor.authorHowell, Anthonyen
dc.contributor.authorBundred, Nigel Jen
dc.date.accessioned2009-12-15T16:27:39Z-
dc.date.available2009-12-15T16:27:39Z-
dc.date.issued1999-11-
dc.identifier.citationTwo-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast. 1999, 84 (11):4017-24 J. Clin. Endocrinol. Metab.en
dc.identifier.issn0021-972X-
dc.identifier.pmid10566643-
dc.identifier.doi10.1210/jc.84.11.4017-
dc.identifier.urihttp://hdl.handle.net/10541/88011-
dc.description.abstractAn association has been reported between consumption of a high soy diet and a low incidence of breast cancer within populations of Southeast Asia. Phytoestrogens present in soy act as partial estrogen agonists or antagonists and can inhibit breast cancer cell proliferation in vitro. The effect of 14-day dietary soy supplementation with 60 g (45 mg isoflavones) on the normal breast of 84 premenopausal patients was determined. Serum concentrations of the isoflavanoids, genistein, daidzein, and equol, were raised in patients after soy supplementation (P < or = 0.025). Nipple aspirate (NA) levels of genistein and daidzein were higher than paired serum levels, both before (P < 0.001 and P = 0.001, respectively) and after soy supplementation (P < 0.001 and P = 0.049, respectively); however, there was no significant increase in NA isoflavone levels in response to soy. NA levels of apolipoprotein D were significantly lowered and pS2 levels raised in response to soy supplementation (P < or = 0.002), indicative of an estrogenic stimulus. No effect of soy supplementation on breast epithelial cell proliferation, estrogen and progesterone receptor status, apoptosis, mitosis, or Bcl-2 expression was detected. In conclusion, short term dietary soy has a weak estrogenic response on the breast, as measured by nipple aspirate apolipoprotein D and pS2 expression. No antiestrogenic effect of soy on the breast was detected.en
dc.language.isoenen
dc.subjectNon-Steroidal Oestrogenen
dc.subjectTumour Suppressor Proteinsen
dc.subject.meshAdult-
dc.subject.meshApolipoproteins-
dc.subject.meshApolipoproteins D-
dc.subject.meshBody Fluids-
dc.subject.meshChromans-
dc.subject.meshDiet-
dc.subject.meshEstrogens, Non-Steroidal-
dc.subject.meshFemale-
dc.subject.meshGenistein-
dc.subject.meshHumans-
dc.subject.meshIsoflavones-
dc.subject.meshNipples-
dc.subject.meshPhytoestrogens-
dc.subject.meshPlant Preparations-
dc.subject.meshProteins-
dc.subject.meshSoybean Proteins-
dc.subject.meshSoybeans-
dc.subject.meshSuction-
dc.subject.meshTumor Suppressor Proteins-
dc.titleTwo-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast.en
dc.typeArticleen
dc.contributor.departmentEpithelial Biology Group, Paterson Institute for Cancer Research.en
dc.identifier.journalThe Journal of Clinical Endocrinology and Metabolismen

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