Myofibroblastoma of breast: evidence favoring smooth-muscle rather than myofibroblastic differentiation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/87998
Title:
Myofibroblastoma of breast: evidence favoring smooth-muscle rather than myofibroblastic differentiation.
Authors:
Eyden, Brian P; Shanks, Jonathan H; Ioachim, E; Ali, H H; Christensen, L; Howat, A J
Abstract:
A histopathological study of two cases of the tumor known in the literature as myofibroblastoma of the breast is presented. The tumors occurred in Caucasian males aged 57 and 62 years. Histologically, these were moderately cellular, lobulated spindle-cell lesions, each with a reasonably well-delineated edge with surrounding fatty connective tissue. No breast ducts or lobules were present. Tumor cell nuclei were bland, with small nucleoli and some nuclear grooving. Nuclear atypia and mitoses were absent. Immunostaining revealed positivity for a-smooth-muscle actin, desmin, and CD34. Tumor cells contained rough endoplasmic reticulum, bundles of myofilaments with focal densities, intermediate filaments, attachment plaques alternating with plasmalemmal caveolae, and focal lamina. Ultrastructural findings pointed to true smooth-muscle differentiation, and the cell-surface in particular lacked surface features of myofibroblasts (fibronectin fibrils [microtendons] and fibronexus junctions). These and published data suggest that at least some of the lesions referred to in the literature as myofibroblastoma may not be myofibroblastic and may be better designated as myogenic stromal tumors or as variants of leiomyoma.
Affiliation:
Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, UK.
Citation:
Myofibroblastoma of breast: evidence favoring smooth-muscle rather than myofibroblastic differentiation., 23 (4):249-57 Ultrastruct Pathol
Journal:
Ultrastructural Pathology
Issue Date:
1999
URI:
http://hdl.handle.net/10541/87998
DOI:
10.1080/019131299281581
PubMed ID:
10503744
Type:
Article
Language:
en
ISSN:
0191-3123
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorShanks, Jonathan Hen
dc.contributor.authorIoachim, Een
dc.contributor.authorAli, H Hen
dc.contributor.authorChristensen, Len
dc.contributor.authorHowat, A Jen
dc.date.accessioned2009-12-15T15:31:32Z-
dc.date.available2009-12-15T15:31:32Z-
dc.date.issued1999-
dc.identifier.citationMyofibroblastoma of breast: evidence favoring smooth-muscle rather than myofibroblastic differentiation., 23 (4):249-57 Ultrastruct Patholen
dc.identifier.issn0191-3123-
dc.identifier.pmid10503744-
dc.identifier.doi10.1080/019131299281581-
dc.identifier.urihttp://hdl.handle.net/10541/87998-
dc.description.abstractA histopathological study of two cases of the tumor known in the literature as myofibroblastoma of the breast is presented. The tumors occurred in Caucasian males aged 57 and 62 years. Histologically, these were moderately cellular, lobulated spindle-cell lesions, each with a reasonably well-delineated edge with surrounding fatty connective tissue. No breast ducts or lobules were present. Tumor cell nuclei were bland, with small nucleoli and some nuclear grooving. Nuclear atypia and mitoses were absent. Immunostaining revealed positivity for a-smooth-muscle actin, desmin, and CD34. Tumor cells contained rough endoplasmic reticulum, bundles of myofilaments with focal densities, intermediate filaments, attachment plaques alternating with plasmalemmal caveolae, and focal lamina. Ultrastructural findings pointed to true smooth-muscle differentiation, and the cell-surface in particular lacked surface features of myofibroblasts (fibronectin fibrils [microtendons] and fibronexus junctions). These and published data suggest that at least some of the lesions referred to in the literature as myofibroblastoma may not be myofibroblastic and may be better designated as myogenic stromal tumors or as variants of leiomyoma.en
dc.language.isoenen
dc.subjectMale Breast Canceren
dc.subjectMuscle Tissue Canceren
dc.subject.meshActins-
dc.subject.meshAntigens, CD34-
dc.subject.meshBreast Neoplasms, Male-
dc.subject.meshCytoplasm-
dc.subject.meshDesmin-
dc.subject.meshFibroblasts-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLeiomyoma-
dc.subject.meshMale-
dc.subject.meshMicrofilaments-
dc.subject.meshMiddle Aged-
dc.subject.meshMuscle, Smooth-
dc.subject.meshNeoplasms, Muscle Tissue-
dc.subject.meshVimentin-
dc.titleMyofibroblastoma of breast: evidence favoring smooth-muscle rather than myofibroblastic differentiation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital National Health Service Trust, Manchester, UK.en
dc.identifier.journalUltrastructural Pathologyen

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