Gonadotrophin-releasing hormone analogues: a novel treatment for premenstrual asthma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/87917
Title:
Gonadotrophin-releasing hormone analogues: a novel treatment for premenstrual asthma.
Authors:
Murray, Robert D; New, J P; Barber, Philip V; Shalet, Stephen M
Abstract:
Premenstrual exacerbation of asthma, as reflected by a reduction in peak expiratory flow rate (PEFR), has been demonstrated in 40-100% of female asthmatics. Epidemiological data demonstrate that admission to hospital with an exacerbation of asthma occurs more frequently perimenstrually. Therapeutic interventions aimed at modifying this precipitating factor, however, remain limited. We report on a 32-yr old female with asthma in whom a marked increase in symptoms and reduction in PEFR occurred premenstrually, necessitating recurrent admissions to hospital. Frequent severe exacerbations resulted in the chronic use of oral maintenance corticosteroids. In order to suppress gonadotrophin secretion and ovarian function, a long-acting gonadotrophin-releasing hormone analogue was administered with a view to inducing a reversible menopause. This resulted in improvement in respiratory symptoms, the absence of PEFR dips premenstrually, a reduction in maintenance prednisolone dosage and no further hospital admissions during a follow-up period of 14 months. The authors propose that gonadotrophin-releasing hormone-analogue therapy is a rational and innovative adjuvant treatment worthy of further study in cases of severe premenstrual asthma.
Affiliation:
Dept of Endocrinology, Christie Hospital, Manchester, UK.
Citation:
Gonadotrophin-releasing hormone analogues: a novel treatment for premenstrual asthma. 1999, 14 (4):966-7 Eur. Respir. J.
Journal:
The European Respiratory Journal
Issue Date:
Oct-1999
URI:
http://hdl.handle.net/10541/87917
PubMed ID:
10573250
Type:
Article
Language:
en
ISSN:
0903-1936
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMurray, Robert Den
dc.contributor.authorNew, J Pen
dc.contributor.authorBarber, Philip Ven
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2009-12-14T16:12:51Z-
dc.date.available2009-12-14T16:12:51Z-
dc.date.issued1999-10-
dc.identifier.citationGonadotrophin-releasing hormone analogues: a novel treatment for premenstrual asthma. 1999, 14 (4):966-7 Eur. Respir. J.en
dc.identifier.issn0903-1936-
dc.identifier.pmid10573250-
dc.identifier.urihttp://hdl.handle.net/10541/87917-
dc.description.abstractPremenstrual exacerbation of asthma, as reflected by a reduction in peak expiratory flow rate (PEFR), has been demonstrated in 40-100% of female asthmatics. Epidemiological data demonstrate that admission to hospital with an exacerbation of asthma occurs more frequently perimenstrually. Therapeutic interventions aimed at modifying this precipitating factor, however, remain limited. We report on a 32-yr old female with asthma in whom a marked increase in symptoms and reduction in PEFR occurred premenstrually, necessitating recurrent admissions to hospital. Frequent severe exacerbations resulted in the chronic use of oral maintenance corticosteroids. In order to suppress gonadotrophin secretion and ovarian function, a long-acting gonadotrophin-releasing hormone analogue was administered with a view to inducing a reversible menopause. This resulted in improvement in respiratory symptoms, the absence of PEFR dips premenstrually, a reduction in maintenance prednisolone dosage and no further hospital admissions during a follow-up period of 14 months. The authors propose that gonadotrophin-releasing hormone-analogue therapy is a rational and innovative adjuvant treatment worthy of further study in cases of severe premenstrual asthma.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAnti-Asthmatic Agents-
dc.subject.meshAsthma-
dc.subject.meshDrug Therapy, Combination-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGoserelin-
dc.subject.meshHumans-
dc.subject.meshPeak Expiratory Flow Rate-
dc.subject.meshPremenstrual Syndrome-
dc.titleGonadotrophin-releasing hormone analogues: a novel treatment for premenstrual asthma.en
dc.typeArticleen
dc.contributor.departmentDept of Endocrinology, Christie Hospital, Manchester, UK.en
dc.identifier.journalThe European Respiratory Journalen

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