Early investigation and initiation of therapy for invasive pulmonary aspergillosis in leukaemic and bone marrow transplant patients.

2.50
Hdl Handle:
http://hdl.handle.net/10541/87906
Title:
Early investigation and initiation of therapy for invasive pulmonary aspergillosis in leukaemic and bone marrow transplant patients.
Authors:
Barnes, Amanda J; Oppenheim, B A; Chang, James; Morgenstern, Godfrey R; Scarffe, J Howard
Abstract:
Invasive fungal infections are an increasingly common problem in cancer patients and in other vulnerable groups. Invasive pulmonary aspergillosis (IPA) in the neutropenic host presents particular challenges in terms of diagnosis and therapy. Against the background of a recognized problem of invasive aspergillosis in haematology/oncology patients treated at the Christie Hospital, we undertook a prospective study in patients at risk for IPA. The aim of the study was to improve outcome by using the linked strategies of first, early diagnosis, and secondly, early aggressive therapy with a lipid-associated formulation of amphotericin B, amphotericin B colloidal dispersion ('Amphocil'). Early investigation comprised the use of high-resolution computerized tomography scanning of the thorax and fibreoptic bronchoscopy to obtain bronchoalveolar lavage specimens, processed using conventional detection and culture methods. Using this approach, the incidence of proven or probable IPA in patients with acute leukaemia was 9%. Prompt initiation of amphotericin B colloidal dispersion therapy led to a successful outcome in 11 of 13 patients, compared with a mortality of 100% in historical controls.
Affiliation:
Public Health Laboratory, Withington Hospital, Manchester, UK.
Citation:
Early investigation and initiation of therapy for invasive pulmonary aspergillosis in leukaemic and bone marrow transplant patients. 1999, 42 (5-6):403-8 Mycoses
Journal:
Mycoses
Issue Date:
1999
URI:
http://hdl.handle.net/10541/87906
DOI:
10.1046/j.1439-0507.1999.00483.x
PubMed ID:
10536432
Type:
Article
Language:
en
ISSN:
0933-7407
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBarnes, Amanda Jen
dc.contributor.authorOppenheim, B Aen
dc.contributor.authorChang, Jamesen
dc.contributor.authorMorgenstern, Godfrey Ren
dc.contributor.authorScarffe, J Howarden
dc.date.accessioned2009-12-14T15:40:31Z-
dc.date.available2009-12-14T15:40:31Z-
dc.date.issued1999-
dc.identifier.citationEarly investigation and initiation of therapy for invasive pulmonary aspergillosis in leukaemic and bone marrow transplant patients. 1999, 42 (5-6):403-8 Mycosesen
dc.identifier.issn0933-7407-
dc.identifier.pmid10536432-
dc.identifier.doi10.1046/j.1439-0507.1999.00483.x-
dc.identifier.urihttp://hdl.handle.net/10541/87906-
dc.description.abstractInvasive fungal infections are an increasingly common problem in cancer patients and in other vulnerable groups. Invasive pulmonary aspergillosis (IPA) in the neutropenic host presents particular challenges in terms of diagnosis and therapy. Against the background of a recognized problem of invasive aspergillosis in haematology/oncology patients treated at the Christie Hospital, we undertook a prospective study in patients at risk for IPA. The aim of the study was to improve outcome by using the linked strategies of first, early diagnosis, and secondly, early aggressive therapy with a lipid-associated formulation of amphotericin B, amphotericin B colloidal dispersion ('Amphocil'). Early investigation comprised the use of high-resolution computerized tomography scanning of the thorax and fibreoptic bronchoscopy to obtain bronchoalveolar lavage specimens, processed using conventional detection and culture methods. Using this approach, the incidence of proven or probable IPA in patients with acute leukaemia was 9%. Prompt initiation of amphotericin B colloidal dispersion therapy led to a successful outcome in 11 of 13 patients, compared with a mortality of 100% in historical controls.en
dc.language.isoenen
dc.subjectLeukaemiaen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAmphotericin B-
dc.subject.meshAspergillosis-
dc.subject.meshBone Marrow Transplantation-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLeukemia-
dc.subject.meshLung Diseases, Fungal-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.titleEarly investigation and initiation of therapy for invasive pulmonary aspergillosis in leukaemic and bone marrow transplant patients.en
dc.typeArticleen
dc.contributor.departmentPublic Health Laboratory, Withington Hospital, Manchester, UK.en
dc.identifier.journalMycosesen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.