Small cell carcinoma of the uterine cervix: a clinicopathological review.

2.50
Hdl Handle:
http://hdl.handle.net/10541/87878
Title:
Small cell carcinoma of the uterine cervix: a clinicopathological review.
Authors:
Sykes, Andrew J; Shanks, Jonathan H; Davidson, Susan E
Abstract:
Small cell carcinoma of the cervix is rare, with an aggressive natural history. We report on a series of 11 patients treated at the Christie Hospital, Manchester and examine their treatment and survival. Eleven patients with small cell carcinoma of the cervix were identified retrospectively from patient case notes. Treatment was individualised and included a variety of combinations of surgery radiotherapy and chemotherapy. Four patients were disease-free between 21 and 108 months (crude disease-free survival 36%). They presented with earlier disease and were older than the average for the group. They were all initially treated with radical radiotherapy. 7 patients died between 7 and 25 months. Despite combination chemotherapy, survival with advanced disease was poor. Published studies are small and fail to provide definitive answers on the best management of small cell carcinoma of the cervix. Drawing on the experience of small cell carcinoma of the lung however, combination therapy with radiotherapy, chemotherapy and possibly surgery requires careful assessment by an oncologist.
Affiliation:
Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.
Citation:
Small cell carcinoma of the uterine cervix: a clinicopathological review. 1999, 14 (2):381-6 Int. J. Oncol.
Journal:
International Journal of Oncology
Issue Date:
Feb-1999
URI:
http://hdl.handle.net/10541/87878
PubMed ID:
9917517
Type:
Article
Language:
en
ISSN:
1019-6439
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSykes, Andrew Jen
dc.contributor.authorShanks, Jonathan Hen
dc.contributor.authorDavidson, Susan Een
dc.date.accessioned2009-12-14T13:29:03Z-
dc.date.available2009-12-14T13:29:03Z-
dc.date.issued1999-02-
dc.identifier.citationSmall cell carcinoma of the uterine cervix: a clinicopathological review. 1999, 14 (2):381-6 Int. J. Oncol.en
dc.identifier.issn1019-6439-
dc.identifier.pmid9917517-
dc.identifier.urihttp://hdl.handle.net/10541/87878-
dc.description.abstractSmall cell carcinoma of the cervix is rare, with an aggressive natural history. We report on a series of 11 patients treated at the Christie Hospital, Manchester and examine their treatment and survival. Eleven patients with small cell carcinoma of the cervix were identified retrospectively from patient case notes. Treatment was individualised and included a variety of combinations of surgery radiotherapy and chemotherapy. Four patients were disease-free between 21 and 108 months (crude disease-free survival 36%). They presented with earlier disease and were older than the average for the group. They were all initially treated with radical radiotherapy. 7 patients died between 7 and 25 months. Despite combination chemotherapy, survival with advanced disease was poor. Published studies are small and fail to provide definitive answers on the best management of small cell carcinoma of the cervix. Drawing on the experience of small cell carcinoma of the lung however, combination therapy with radiotherapy, chemotherapy and possibly surgery requires careful assessment by an oncologist.en
dc.language.isoenen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshCarcinoma, Small Cell-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshSurvival Analysis-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleSmall cell carcinoma of the uterine cervix: a clinicopathological review.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.en
dc.identifier.journalInternational Journal of Oncologyen

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