The accuracy of diagnoses as reported in families with cancer: a retrospective study.

2.50
Hdl Handle:
http://hdl.handle.net/10541/87852
Title:
The accuracy of diagnoses as reported in families with cancer: a retrospective study.
Authors:
Douglas, Fiona S; O'Dair, Lindsay; Robinson, Marion; Evans, D Gareth R; Lynch, Sally A
Abstract:
Assessment of risk of developing hereditary cancer and subsequent clinical surveillance is largely based on family history. It is considered standard practice to confirm as many diagnoses as possible in cancer families. Our aim was (1) to assess inaccuracies in reporting of cancers by families, (2) to assess the need for confirmation of diagnosis, and (3) to estimate how many families would have been entered unnecessarily or excluded from screening. A retrospective study of 595 case notes was performed in two centres. Methods of confirmation included information from the cancer registries, death certificates, hospital notes, and histopathological records. Accuracy varied by site of cancer and by the closeness of the relationship to the affected person. Reported abdominal malignancies were inaccurate in 20%, whereas 5% of reported breast cancers were inaccurate. In two families the family history of cancer proved fictitious. Management was altered in 231213 (11%) families following cancer confirmation. The results of the study favour verification of cancer diagnoses particularly if decisions regarding surveillance or prophylactic surgery are based on the family history.
Affiliation:
Department of Medical Genetics, St Mary's Hospital, Manchester, UK.
Citation:
The accuracy of diagnoses as reported in families with cancer: a retrospective study. 1999, 36 (4):309-12 J. Med. Genet.
Journal:
Journal of Medical Genetics
Issue Date:
Apr-1999
URI:
http://hdl.handle.net/10541/87852
DOI:
10.1136/jmg.36.4.309
PubMed ID:
10227399
Type:
Article
Language:
en
ISSN:
0022-2593
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDouglas, Fiona Sen
dc.contributor.authorO'Dair, Lindsayen
dc.contributor.authorRobinson, Marionen
dc.contributor.authorEvans, D Gareth Ren
dc.contributor.authorLynch, Sally Aen
dc.date.accessioned2009-12-14T13:16:32Z-
dc.date.available2009-12-14T13:16:32Z-
dc.date.issued1999-04-
dc.identifier.citationThe accuracy of diagnoses as reported in families with cancer: a retrospective study. 1999, 36 (4):309-12 J. Med. Genet.en
dc.identifier.issn0022-2593-
dc.identifier.pmid10227399-
dc.identifier.doi10.1136/jmg.36.4.309-
dc.identifier.urihttp://hdl.handle.net/10541/87852-
dc.description.abstractAssessment of risk of developing hereditary cancer and subsequent clinical surveillance is largely based on family history. It is considered standard practice to confirm as many diagnoses as possible in cancer families. Our aim was (1) to assess inaccuracies in reporting of cancers by families, (2) to assess the need for confirmation of diagnosis, and (3) to estimate how many families would have been entered unnecessarily or excluded from screening. A retrospective study of 595 case notes was performed in two centres. Methods of confirmation included information from the cancer registries, death certificates, hospital notes, and histopathological records. Accuracy varied by site of cancer and by the closeness of the relationship to the affected person. Reported abdominal malignancies were inaccurate in 20%, whereas 5% of reported breast cancers were inaccurate. In two families the family history of cancer proved fictitious. Management was altered in 231213 (11%) families following cancer confirmation. The results of the study favour verification of cancer diagnoses particularly if decisions regarding surveillance or prophylactic surgery are based on the family history.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshFamily Health-
dc.subject.meshHumans-
dc.subject.meshMedical Records-
dc.subject.meshNeoplasms-
dc.subject.meshRetrospective Studies-
dc.titleThe accuracy of diagnoses as reported in families with cancer: a retrospective study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Genetics, St Mary's Hospital, Manchester, UK.en
dc.identifier.journalJournal of Medical Geneticsen

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