2.50
Hdl Handle:
http://hdl.handle.net/10541/86672
Title:
Stem cells: the intestinal stem cell as a paradigm.
Authors:
Bach, Simon P; Renehan, Andrew G; Potten, Christopher S
Abstract:
Stem cell research provides a foundation for therapeutic advancement in oncology, clinical genetics and a diverse array of degenerative disorders. For example, the elucidation of pathways governing proliferative regulation and differentiation within cellular systems will result in medical strategies aimed at the root cause of cancer. At present the characterization of reliable stem cell markers is the immediate aim in this particular field. Over the past 30 years investigators have determined many of the physical and functional properties of stem cells through careful and imaginative experimentation. Intestinal stem cells reside at the crypt base and give rise to all cell types found within the crypt. They readily undergo altruistic apoptosis in response to toxic stimuli although their progeny are hardier and will regain stem cell function to repopulate the tissue compartment, giving rise to the concept of a proliferative hierarchy. Contention exists when deciding whether the full complement of cells within a crypt is derived from either a single or multiple stems. Evidence has also arisen to challenge the long held view that colorectal tumours arise from a single mutated stem cell, as early adenomas from a human XO/XY mosaic contained distinct clones. Mechanisms governing the stem cell cycle and subsequent proliferative activity largely remain obscure. The adenomatous polyposis coli gene product has, however, been shown to promote the degradation of beta-catenin, an enhancer of cell proliferation, thereby downregulating this activity in healthy individuals.
Affiliation:
CRC Department of Epithelial Biology, Paterson Institute for Cancer Research and Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester, UK.
Citation:
Stem cells: the intestinal stem cell as a paradigm. 2000, 21 (3):469-76 Carcinogenesis
Journal:
Carcinogenesis
Issue Date:
Mar-2000
URI:
http://hdl.handle.net/10541/86672
DOI:
10.1093/carcin/21.3.469
PubMed ID:
10688867
Type:
Article
Language:
en
ISSN:
0143-3334
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBach, Simon Pen
dc.contributor.authorRenehan, Andrew Gen
dc.contributor.authorPotten, Christopher Sen
dc.date.accessioned2009-11-23T12:13:46Z-
dc.date.available2009-11-23T12:13:46Z-
dc.date.issued2000-03-
dc.identifier.citationStem cells: the intestinal stem cell as a paradigm. 2000, 21 (3):469-76 Carcinogenesisen
dc.identifier.issn0143-3334-
dc.identifier.pmid10688867-
dc.identifier.doi10.1093/carcin/21.3.469-
dc.identifier.urihttp://hdl.handle.net/10541/86672-
dc.description.abstractStem cell research provides a foundation for therapeutic advancement in oncology, clinical genetics and a diverse array of degenerative disorders. For example, the elucidation of pathways governing proliferative regulation and differentiation within cellular systems will result in medical strategies aimed at the root cause of cancer. At present the characterization of reliable stem cell markers is the immediate aim in this particular field. Over the past 30 years investigators have determined many of the physical and functional properties of stem cells through careful and imaginative experimentation. Intestinal stem cells reside at the crypt base and give rise to all cell types found within the crypt. They readily undergo altruistic apoptosis in response to toxic stimuli although their progeny are hardier and will regain stem cell function to repopulate the tissue compartment, giving rise to the concept of a proliferative hierarchy. Contention exists when deciding whether the full complement of cells within a crypt is derived from either a single or multiple stems. Evidence has also arisen to challenge the long held view that colorectal tumours arise from a single mutated stem cell, as early adenomas from a human XO/XY mosaic contained distinct clones. Mechanisms governing the stem cell cycle and subsequent proliferative activity largely remain obscure. The adenomatous polyposis coli gene product has, however, been shown to promote the degradation of beta-catenin, an enhancer of cell proliferation, thereby downregulating this activity in healthy individuals.en
dc.language.isoenen
dc.subjectColorectal Canceren
dc.subjectTumour Suppressor Protein p53en
dc.subject.meshAdenomatous Polyposis Coli-
dc.subject.meshAnimals-
dc.subject.meshCell Differentiation-
dc.subject.meshCell Division-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshCyclin-Dependent Kinase Inhibitor p21-
dc.subject.meshCyclins-
dc.subject.meshCyclooxygenase 2-
dc.subject.meshGlucagon-Like Peptides-
dc.subject.meshHumans-
dc.subject.meshIntestinal Mucosa-
dc.subject.meshIntestines-
dc.subject.meshIsoenzymes-
dc.subject.meshMembrane Proteins-
dc.subject.meshNeoplasms-
dc.subject.meshPeptides-
dc.subject.meshProstaglandin-Endoperoxide Synthases-
dc.subject.meshProto-Oncogene Proteins c-bcl-2-
dc.subject.meshSignal Transduction-
dc.subject.meshStem Cells-
dc.subject.meshTransforming Growth Factor beta-
dc.subject.meshTumor Suppressor Protein p53-
dc.titleStem cells: the intestinal stem cell as a paradigm.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Epithelial Biology, Paterson Institute for Cancer Research and Department of Surgery, Christie Hospital NHS Trust, Wilmslow Road, Manchester, UK.en
dc.identifier.journalCarcinogenesisen
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