P27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium.

2.50
Hdl Handle:
http://hdl.handle.net/10541/86670
Title:
P27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium.
Authors:
Clarke, Robert B; Howell, Anthony ( 0000-0002-3879-5991 ) ; Potten, Christopher S; Anderson, Elizabeth
Abstract:
To test the hypothesis that steroid receptor-expressing cells are derived from the proliferative population, we examined expression of the p27(KIP1) inhibitor of cyclin-dependent kinase activity (a differentiation marker) while tracking the fate of proliferating cells in normal human breast tissue implanted into athymic nude mice using tritiated thymidine [3H]-dT. We identified a small number of cells that appeared to have divided just once before switching on p27(KIP1) expression. p27(KIP1)+ve cells also expressed steroid receptors, but not the Ki67 proliferation-associated antigen. These data support the hypothesis that steroid receptor-expressing cells are a differentiated population within the normal human breast epithelium.
Affiliation:
Clinical Research Department, Christie Hospital, M20 4BX, Manchester, UK.
Citation:
P27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium. 2000, 36 Suppl 4:S28-9 Eur. J. Cancer
Journal:
European Journal of Cancer
Issue Date:
Sep-2000
URI:
http://hdl.handle.net/10541/86670
DOI:
10.1016/S0959-8049(00)00212-4
PubMed ID:
11056305
Type:
Article
Language:
en
ISSN:
0959-8049
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorClarke, Robert Ben
dc.contributor.authorHowell, Anthonyen
dc.contributor.authorPotten, Christopher Sen
dc.contributor.authorAnderson, Elizabethen
dc.date.accessioned2009-11-23T12:07:05Z-
dc.date.available2009-11-23T12:07:05Z-
dc.date.issued2000-09-
dc.identifier.citationP27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium. 2000, 36 Suppl 4:S28-9 Eur. J. Canceren
dc.identifier.issn0959-8049-
dc.identifier.pmid11056305-
dc.identifier.doi10.1016/S0959-8049(00)00212-4-
dc.identifier.urihttp://hdl.handle.net/10541/86670-
dc.description.abstractTo test the hypothesis that steroid receptor-expressing cells are derived from the proliferative population, we examined expression of the p27(KIP1) inhibitor of cyclin-dependent kinase activity (a differentiation marker) while tracking the fate of proliferating cells in normal human breast tissue implanted into athymic nude mice using tritiated thymidine [3H]-dT. We identified a small number of cells that appeared to have divided just once before switching on p27(KIP1) expression. p27(KIP1)+ve cells also expressed steroid receptors, but not the Ki67 proliferation-associated antigen. These data support the hypothesis that steroid receptor-expressing cells are a differentiated population within the normal human breast epithelium.en
dc.language.isoenen
dc.subjectTumour Suppressor Proteinsen
dc.subject.meshAnimals-
dc.subject.meshBiological Markers-
dc.subject.meshBreast-
dc.subject.meshCell Cycle Proteins-
dc.subject.meshCell Differentiation-
dc.subject.meshCyclin-Dependent Kinase Inhibitor p27-
dc.subject.meshEpithelium-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshKi-67 Antigen-
dc.subject.meshMice-
dc.subject.meshMice, Nude-
dc.subject.meshMicrotubule-Associated Proteins-
dc.subject.meshTumor Suppressor Proteins-
dc.titleP27(KIP1) expression indicates that steroid receptor-positive cells are a non-proliferating, differentiated subpopulation of the normal human breast epithelium.en
dc.typeArticleen
dc.contributor.departmentClinical Research Department, Christie Hospital, M20 4BX, Manchester, UK.en
dc.identifier.journalEuropean Journal of Canceren
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