Metastatic renal cell carcinoma to the nose and paranasal sinuses.

2.50
Hdl Handle:
http://hdl.handle.net/10541/86645
Title:
Metastatic renal cell carcinoma to the nose and paranasal sinuses.
Authors:
Simo, Ricard; Sykes, Andrew J; Hargreaves, Simon P; Axon, Patrick R; Birzgalis, Andrew R; Slevin, Nicholas J ( 0000-0002-3367-7013 ) ; Farrington, William T
Abstract:
BACKGROUND: Renal cell carcinoma represents 3% of all malignant tumors. Metastatic deposits of renal cell carcinoma to the head and neck region are infrequent. The objective of this work is to analyze the clinical presentation, radiologic features, surgical and radiotherapy treatment, and outcome of metastatic renal cell carcinoma to the nose and sinuses. METHODS: Retrospective review of 6 patients diagnosed with renal cell carcinoma who had nasal metastasis develop and were seen at the Christie Hospital in Manchester over the past 8 years. RESULTS: Six patients with renal cell carcinoma were seen with recurrent epistaxis, nasal obstruction, and unpleasant nasal crusting. Three patients had orbital involvement. Examination under general anaesthesia and biopsy was performed in all 6 cases. Histologic studies confirmed metastases of renal cell carcinoma in all 6 patients. All patients underwent local external beam radiotherapy. The most common dose used was 35 Gy in 8 daily fractions. All patients had symptomatic control of local nasal disease with a minimum follow-up of 2 years in 4 patients. Two patients died within 6 months of the radiotherapy treatment as a result of their primary tumor. CONCLUSIONS: Metastatic renal cell carcinoma to the nose and paranasal sinuses is rare but has unpleasant symptoms. Local symptomatic control with radiotherapy is excellent.
Affiliation:
University Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Lewisham, Lewisham High Street, London SE13 6LR, United Kingdom.
Citation:
Metastatic renal cell carcinoma to the nose and paranasal sinuses. 2000, 22 (7):722-7 Head Neck
Journal:
Head & Neck
Issue Date:
Oct-2000
URI:
http://hdl.handle.net/10541/86645
DOI:
10.1002/1097-0347(200010)22:7<722::AID-HED13>3.0.CO;2-0
PubMed ID:
11002329
Type:
Article
Language:
en
ISSN:
1043-3074
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorSimo, Ricarden
dc.contributor.authorSykes, Andrew Jen
dc.contributor.authorHargreaves, Simon Pen
dc.contributor.authorAxon, Patrick Ren
dc.contributor.authorBirzgalis, Andrew Ren
dc.contributor.authorSlevin, Nicholas Jen
dc.contributor.authorFarrington, William Ten
dc.date.accessioned2009-11-23T10:11:05Z-
dc.date.available2009-11-23T10:11:05Z-
dc.date.issued2000-10-
dc.identifier.citationMetastatic renal cell carcinoma to the nose and paranasal sinuses. 2000, 22 (7):722-7 Head Necken
dc.identifier.issn1043-3074-
dc.identifier.pmid11002329-
dc.identifier.doi10.1002/1097-0347(200010)22:7<722::AID-HED13>3.0.CO;2-0-
dc.identifier.urihttp://hdl.handle.net/10541/86645-
dc.description.abstractBACKGROUND: Renal cell carcinoma represents 3% of all malignant tumors. Metastatic deposits of renal cell carcinoma to the head and neck region are infrequent. The objective of this work is to analyze the clinical presentation, radiologic features, surgical and radiotherapy treatment, and outcome of metastatic renal cell carcinoma to the nose and sinuses. METHODS: Retrospective review of 6 patients diagnosed with renal cell carcinoma who had nasal metastasis develop and were seen at the Christie Hospital in Manchester over the past 8 years. RESULTS: Six patients with renal cell carcinoma were seen with recurrent epistaxis, nasal obstruction, and unpleasant nasal crusting. Three patients had orbital involvement. Examination under general anaesthesia and biopsy was performed in all 6 cases. Histologic studies confirmed metastases of renal cell carcinoma in all 6 patients. All patients underwent local external beam radiotherapy. The most common dose used was 35 Gy in 8 daily fractions. All patients had symptomatic control of local nasal disease with a minimum follow-up of 2 years in 4 patients. Two patients died within 6 months of the radiotherapy treatment as a result of their primary tumor. CONCLUSIONS: Metastatic renal cell carcinoma to the nose and paranasal sinuses is rare but has unpleasant symptoms. Local symptomatic control with radiotherapy is excellent.en
dc.language.isoenen
dc.subjectKidney Canceren
dc.subjectRenal Canceren
dc.subjectNose Canceren
dc.subjectNasal Canceren
dc.subject.meshAged-
dc.subject.meshBiopsy-
dc.subject.meshCarcinoma, Renal Cell-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshKidney Neoplasms-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNose Neoplasms-
dc.subject.meshParanasal Sinus Neoplasms-
dc.subject.meshPrognosis-
dc.subject.meshRetrospective Studies-
dc.subject.meshTomography, X-Ray Computed-
dc.titleMetastatic renal cell carcinoma to the nose and paranasal sinuses.en
dc.typeArticleen
dc.contributor.departmentUniversity Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Lewisham, Lewisham High Street, London SE13 6LR, United Kingdom.en
dc.identifier.journalHead & Necken

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