Successful treatment of aspergillus brain abscess in a child with acute lymphoblastic leukemia.

2.50
Hdl Handle:
http://hdl.handle.net/10541/86534
Title:
Successful treatment of aspergillus brain abscess in a child with acute lymphoblastic leukemia.
Authors:
Ng, Antony; Gadong, N; Kelsey, Anna M; Denning, David W; Leggate, J; Eden, Tim O B
Abstract:
Cerebral aspergillosis carries a high mortality in immunocompromised patients. However, favorable outcome can be achieved by the prolonged use of antifungal agents and the maintenance of adequate drug levels. The authors report a 2-year-old girl who developed an aspergillus brain abscess during treatment for acute lymphoblastic leukemia. Predisposing factors for the fungal infection and details of the antifungal therapy are described. Prolonged treatment with AmBisome and 5-flucytosine successfully eradicated the lesion, but the girl's antileukemic therapy was compromised due to the infection. She developed a central nervous system and bone marrow relapse 9 and 15 months, respectively, after the initial presentation. The report emphasizes the need for further consideration of effective, long-term antifungal prophylaxis and a careful balance between aggressive treatment for severe infection and antileukemic therapy.
Affiliation:
Department of Pathology, Royal Manchester Children's Hospital, UK.
Citation:
Successful treatment of aspergillus brain abscess in a child with acute lymphoblastic leukemia. 2000, 17 (6):497-504 Pediatr Hematol Oncol
Journal:
Pediatric Hematology and Oncology
Issue Date:
Sep-2000
URI:
http://hdl.handle.net/10541/86534
DOI:
10.1080/08880010050120863
PubMed ID:
10989471
Type:
Article
Language:
en
ISSN:
0888-0018
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorNg, Antonyen
dc.contributor.authorGadong, Nen
dc.contributor.authorKelsey, Anna Men
dc.contributor.authorDenning, David Wen
dc.contributor.authorLeggate, Jen
dc.contributor.authorEden, Tim O Ben
dc.date.accessioned2009-11-19T16:59:14Z-
dc.date.available2009-11-19T16:59:14Z-
dc.date.issued2000-09-
dc.identifier.citationSuccessful treatment of aspergillus brain abscess in a child with acute lymphoblastic leukemia. 2000, 17 (6):497-504 Pediatr Hematol Oncolen
dc.identifier.issn0888-0018-
dc.identifier.pmid10989471-
dc.identifier.doi10.1080/08880010050120863-
dc.identifier.urihttp://hdl.handle.net/10541/86534-
dc.description.abstractCerebral aspergillosis carries a high mortality in immunocompromised patients. However, favorable outcome can be achieved by the prolonged use of antifungal agents and the maintenance of adequate drug levels. The authors report a 2-year-old girl who developed an aspergillus brain abscess during treatment for acute lymphoblastic leukemia. Predisposing factors for the fungal infection and details of the antifungal therapy are described. Prolonged treatment with AmBisome and 5-flucytosine successfully eradicated the lesion, but the girl's antileukemic therapy was compromised due to the infection. She developed a central nervous system and bone marrow relapse 9 and 15 months, respectively, after the initial presentation. The report emphasizes the need for further consideration of effective, long-term antifungal prophylaxis and a careful balance between aggressive treatment for severe infection and antileukemic therapy.en
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Lukaemia-Lymphomaen
dc.subject.meshAmphotericin B-
dc.subject.meshAntibiotics, Antifungal-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshAspergillosis-
dc.subject.meshAspergillus fumigatus-
dc.subject.meshBrain Abscess-
dc.subject.meshCerebral Cortex-
dc.subject.meshChild, Preschool-
dc.subject.meshFemale-
dc.subject.meshFlucytosine-
dc.subject.meshHumans-
dc.subject.meshImmunosuppression-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.titleSuccessful treatment of aspergillus brain abscess in a child with acute lymphoblastic leukemia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Royal Manchester Children's Hospital, UK.en
dc.identifier.journalPediatric Hematology and Oncologyen

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