2.50
Hdl Handle:
http://hdl.handle.net/10541/86508
Title:
Breast cancer diagnosis using scattered X-rays.
Authors:
Lewis, R A; Rogers, K D; Hall, C J; Towns-Andrews, E; Slawson, S; Evans, A; Pinder, S E; Ellis, I O; Boggis, C R; Hufton, Alan P; Dance, D R
Abstract:
Small-angle X-ray diffraction data has been collected from 99 ;core-cut' breast tissue specimens representing a number of different pathologies. Data in the range 75-1390 A have been compared with controls from patients with no breast disease. Bessel functions and Bragg maxima resulting from the fibrillar structure of collagen have been identified. The Bragg maxima indexed onto a 649 A lattice. Systematic differences in the intensities and D-spacings between the collagen of malignant, benign and normal tissue groups have been clearly demonstrated and quantified. These differences appear to be due to a significantly lower structural order within the malignant tissues. Possible explanations for this are discussed and the potential for utilizing this observation in cancer diagnosis is considered.
Affiliation:
Daresbury Laboratory, Warrington WA4 4AD, UK.
Citation:
Breast cancer diagnosis using scattered X-rays. 2000, 7 (Pt 5):348-52 J Synchrotron Radiat
Journal:
Journal of Synchrotron Radiation
Issue Date:
1-Sep-2000
URI:
http://hdl.handle.net/10541/86508
DOI:
10.1107/S0909049500009973
PubMed ID:
16609219
Type:
Article
Language:
en
ISSN:
0909-0495
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLewis, R Aen
dc.contributor.authorRogers, K Den
dc.contributor.authorHall, C Jen
dc.contributor.authorTowns-Andrews, Een
dc.contributor.authorSlawson, Sen
dc.contributor.authorEvans, Aen
dc.contributor.authorPinder, S Een
dc.contributor.authorEllis, I Oen
dc.contributor.authorBoggis, C Ren
dc.contributor.authorHufton, Alan Pen
dc.contributor.authorDance, D Ren
dc.date.accessioned2009-11-19T16:12:28Z-
dc.date.available2009-11-19T16:12:28Z-
dc.date.issued2000-09-01-
dc.identifier.citationBreast cancer diagnosis using scattered X-rays. 2000, 7 (Pt 5):348-52 J Synchrotron Radiaten
dc.identifier.issn0909-0495-
dc.identifier.pmid16609219-
dc.identifier.doi10.1107/S0909049500009973-
dc.identifier.urihttp://hdl.handle.net/10541/86508-
dc.description.abstractSmall-angle X-ray diffraction data has been collected from 99 ;core-cut' breast tissue specimens representing a number of different pathologies. Data in the range 75-1390 A have been compared with controls from patients with no breast disease. Bessel functions and Bragg maxima resulting from the fibrillar structure of collagen have been identified. The Bragg maxima indexed onto a 649 A lattice. Systematic differences in the intensities and D-spacings between the collagen of malignant, benign and normal tissue groups have been clearly demonstrated and quantified. These differences appear to be due to a significantly lower structural order within the malignant tissues. Possible explanations for this are discussed and the potential for utilizing this observation in cancer diagnosis is considered.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCollagenen
dc.subjectDiagnosisen
dc.subjectEnzyme Degradationen
dc.subjectScattered X-Raysen
dc.titleBreast cancer diagnosis using scattered X-rays.en
dc.typeArticleen
dc.contributor.departmentDaresbury Laboratory, Warrington WA4 4AD, UK.en
dc.identifier.journalJournal of Synchrotron Radiationen

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