2.50
Hdl Handle:
http://hdl.handle.net/10541/86454
Title:
Radiotherapy for carcinoma of the posterior pharyngeal wall.
Authors:
Cooper, Rachel A; Slevin, Nicholas J ( 0000-0002-3367-7013 ) ; Carrington, Bernadette M; Sykes, Andrew J; Birzgalis, Andrew R; Mott, David J
Abstract:
Posterior pharyngeal carcinoma has an extremely poor prognosis regardless of the method of treatment. The purpose of this study was to assess the local control and survival in patients with carcinoma of the posterior pharyngeal wall treated with definitive radiotherapy and to determine prognostic factors which may be relevant to the current UICC staging classification. Between January 1991 and December 1995, 22 patients with a mean age of 60 years (range 44-82) received definitive radiotherapy, using a homogeneous technique, for carcinoma of the posterior pharyngeal wall. The median follow-up was 42 months (range 25-66). The overall 3-year survival and local control for the whole group was 50% and 73% respectively. Patients with early stage (T1 and T2) disease had a significantly better overall 3-year survival rate of 77% compared to 11% for patients with advanced stage (T3 and T4) disease (p=0.0010). Similarly, patients with early stage disease had a significantly improved 3-year local control rate compared to patients with more advanced stage disease (92% and 44% respectively, p=0.0080). Patients with node positive disease had an inferior survival rate of 29% compared to 60% for those with node negative disease though the difference did not reach statistical significance. In addition only one patient with initial node negative disease had isolated nodal relapse. There was no significant late morbidity. For patients with early stage disease we have obtained local control and survival rates comparable to other groups with a once daily, short fractionation radiotherapy scheme but with reduced morbidity. In late stage disease altered fractionation schemes should be considered in order to achieve better local control and survival. Isolated nodal relapse was not a significant problem in this cohort of patients. Outcome correlates with primary tumour size and this is reflected in the current UICC staging classification.
Affiliation:
Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.
Citation:
Radiotherapy for carcinoma of the posterior pharyngeal wall. 2000, 16 (3):611-5 Int. J. Oncol.
Journal:
International Journal of Oncology
Issue Date:
Mar-2000
URI:
http://hdl.handle.net/10541/86454
PubMed ID:
10675496
Type:
Article
Language:
en
ISSN:
1019-6439
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCooper, Rachel Aen
dc.contributor.authorSlevin, Nicholas Jen
dc.contributor.authorCarrington, Bernadette Men
dc.contributor.authorSykes, Andrew Jen
dc.contributor.authorBirzgalis, Andrew Ren
dc.contributor.authorMott, David Jen
dc.date.accessioned2009-11-19T10:00:16Z-
dc.date.available2009-11-19T10:00:16Z-
dc.date.issued2000-03-
dc.identifier.citationRadiotherapy for carcinoma of the posterior pharyngeal wall. 2000, 16 (3):611-5 Int. J. Oncol.en
dc.identifier.issn1019-6439-
dc.identifier.pmid10675496-
dc.identifier.urihttp://hdl.handle.net/10541/86454-
dc.description.abstractPosterior pharyngeal carcinoma has an extremely poor prognosis regardless of the method of treatment. The purpose of this study was to assess the local control and survival in patients with carcinoma of the posterior pharyngeal wall treated with definitive radiotherapy and to determine prognostic factors which may be relevant to the current UICC staging classification. Between January 1991 and December 1995, 22 patients with a mean age of 60 years (range 44-82) received definitive radiotherapy, using a homogeneous technique, for carcinoma of the posterior pharyngeal wall. The median follow-up was 42 months (range 25-66). The overall 3-year survival and local control for the whole group was 50% and 73% respectively. Patients with early stage (T1 and T2) disease had a significantly better overall 3-year survival rate of 77% compared to 11% for patients with advanced stage (T3 and T4) disease (p=0.0010). Similarly, patients with early stage disease had a significantly improved 3-year local control rate compared to patients with more advanced stage disease (92% and 44% respectively, p=0.0080). Patients with node positive disease had an inferior survival rate of 29% compared to 60% for those with node negative disease though the difference did not reach statistical significance. In addition only one patient with initial node negative disease had isolated nodal relapse. There was no significant late morbidity. For patients with early stage disease we have obtained local control and survival rates comparable to other groups with a once daily, short fractionation radiotherapy scheme but with reduced morbidity. In late stage disease altered fractionation schemes should be considered in order to achieve better local control and survival. Isolated nodal relapse was not a significant problem in this cohort of patients. Outcome correlates with primary tumour size and this is reflected in the current UICC staging classification.en
dc.language.isoenen
dc.subjectPharyngeal Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPharyngeal Neoplasms-
dc.subject.meshSurvival Rate-
dc.titleRadiotherapy for carcinoma of the posterior pharyngeal wall.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Christie Hospital NHS Trust, Manchester, M20 4BX, UK.en
dc.identifier.journalInternational Journal of Oncologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.