MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study.

2.50
Hdl Handle:
http://hdl.handle.net/10541/86442
Title:
MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study.
Authors:
Cuthbert, G; Thompson, K; McCullough, S; Watmore, A; Dickinson, H; Telford, Nicholas; Mugneret, F; Harrison, C; Griffiths, M; Bown, N
Abstract:
The MLL gene, located at 11q23, is frequently rearranged in acute leukaemia as either chimaeric fusion genes or partial tandem duplications. We report a series of 12 acute leukaemia cases with apparent amplification of the MLL gene ascertained using fluorescence in situ hybridisation (FISH). Seven cases showed intrachromosomal amplification of MLL, four cases showed extrachromosomal amplification as double minute chromosomes (dmin) and one case had separate subclones with dmin and homogenously staining region (hsr). Southern blot analysis of the MLL gene showed MLL gene rearrangement in three of the 10 successful cases. These cases do not naturally fall into either of the two recognised categories of MLL rearrangement and may represent a third variety of MLL gene abnormalities.
Affiliation:
School of Biochemistry and Genetics, University of Newcastle upon Tyne, UK.
Citation:
MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study. 2000, 14 (11):1885-91 Leukemia
Journal:
Leukemia
Issue Date:
Nov-2000
URI:
http://hdl.handle.net/10541/86442
PubMed ID:
11069023
Type:
Article
Language:
en
ISSN:
0887-6924
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCuthbert, Gen
dc.contributor.authorThompson, Ken
dc.contributor.authorMcCullough, Sen
dc.contributor.authorWatmore, Aen
dc.contributor.authorDickinson, Hen
dc.contributor.authorTelford, Nicholasen
dc.contributor.authorMugneret, Fen
dc.contributor.authorHarrison, Cen
dc.contributor.authorGriffiths, Men
dc.contributor.authorBown, Nen
dc.date.accessioned2009-11-19T10:12:20Z-
dc.date.available2009-11-19T10:12:20Z-
dc.date.issued2000-11-
dc.identifier.citationMLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study. 2000, 14 (11):1885-91 Leukemiaen
dc.identifier.issn0887-6924-
dc.identifier.pmid11069023-
dc.identifier.urihttp://hdl.handle.net/10541/86442-
dc.description.abstractThe MLL gene, located at 11q23, is frequently rearranged in acute leukaemia as either chimaeric fusion genes or partial tandem duplications. We report a series of 12 acute leukaemia cases with apparent amplification of the MLL gene ascertained using fluorescence in situ hybridisation (FISH). Seven cases showed intrachromosomal amplification of MLL, four cases showed extrachromosomal amplification as double minute chromosomes (dmin) and one case had separate subclones with dmin and homogenously staining region (hsr). Southern blot analysis of the MLL gene showed MLL gene rearrangement in three of the 10 successful cases. These cases do not naturally fall into either of the two recognised categories of MLL rearrangement and may represent a third variety of MLL gene abnormalities.en
dc.language.isoenen
dc.subjectLeukaemiaen
dc.subjectMyeloid-Lymphoid Leukaemia Proteinen
dc.subject.meshAcute Disease-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBlotting, Southern-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshChromosomes, Human, Pair 11-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshExtrachromosomal Inheritance-
dc.subject.meshFemale-
dc.subject.meshGene Amplification-
dc.subject.meshGreat Britain-
dc.subject.meshHumans-
dc.subject.meshIn Situ Hybridization, Fluorescence-
dc.subject.meshKaryotyping-
dc.subject.meshLeukemia-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMyeloid-Lymphoid Leukemia Protein-
dc.subject.meshProto-Oncogenes-
dc.subject.meshSurvival Analysis-
dc.subject.meshTranscription Factors-
dc.titleMLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study.en
dc.typeArticleen
dc.contributor.departmentSchool of Biochemistry and Genetics, University of Newcastle upon Tyne, UK.en
dc.identifier.journalLeukemiaen

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