Space-time clustering patterns in childhood leukaemia support a role for infection.

2.50
Hdl Handle:
http://hdl.handle.net/10541/86365
Title:
Space-time clustering patterns in childhood leukaemia support a role for infection.
Authors:
Birch, Jillian M; Alexander, F E; Blair, Val; Eden, Tim O B; Taylor, G M; McNally, R J Q
Abstract:
Previous studies of space-time clustering in childhood leukaemia have produced equivocal and inconsistent results. To address this issue we have used Manchester Children's Tumour Registry leukaemia data in space-time clustering analyses. Knox tests for space-time interactions between cases were applied with fixed thresholds of close in space, <5 km and close in time <1 year apart. Addresses at birth as well as diagnosis were utilized. Tests were repeated replacing geographical distance with distance to the Nth nearest neighbour. N was chosen such that the mean distance was 5 km. Data were also examined by a second order procedure based on K-functions. All methods showed highly significant evidence of space-time clustering based on place of birth and time of diagnosis, particularly for all leukaemias aged 0-14 and 0-4 years, and acute lymphoblastic leukaemia (ALL) 0-4 years. Some results based on location at diagnosis were significant but mainly gave larger P-values. The results are consistent with an infectious hypothesis. Furthermore, we found an excess of male cases over females involved in space-time pairs. We suggest this may be related to genetic differences in susceptibility to infection between males and females. These findings provide the basis for future studies to identify possible infectious agents.
Affiliation:
CRC Paediatric & Familial Cancer Research Group, Royal Manchester Children's Hospital, Stancliffe, UK.
Citation:
Space-time clustering patterns in childhood leukaemia support a role for infection. 2000, 82 (9):1571-6 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
May-2000
URI:
http://hdl.handle.net/10541/86365
DOI:
10.1054/bjoc.1999.1072
PubMed ID:
10789727
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorAlexander, F Een
dc.contributor.authorBlair, Valen
dc.contributor.authorEden, Tim O Ben
dc.contributor.authorTaylor, G Men
dc.contributor.authorMcNally, R J Qen
dc.date.accessioned2009-11-18T11:25:44Z-
dc.date.available2009-11-18T11:25:44Z-
dc.date.issued2000-05-
dc.identifier.citationSpace-time clustering patterns in childhood leukaemia support a role for infection. 2000, 82 (9):1571-6 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid10789727-
dc.identifier.doi10.1054/bjoc.1999.1072-
dc.identifier.urihttp://hdl.handle.net/10541/86365-
dc.description.abstractPrevious studies of space-time clustering in childhood leukaemia have produced equivocal and inconsistent results. To address this issue we have used Manchester Children's Tumour Registry leukaemia data in space-time clustering analyses. Knox tests for space-time interactions between cases were applied with fixed thresholds of close in space, <5 km and close in time <1 year apart. Addresses at birth as well as diagnosis were utilized. Tests were repeated replacing geographical distance with distance to the Nth nearest neighbour. N was chosen such that the mean distance was 5 km. Data were also examined by a second order procedure based on K-functions. All methods showed highly significant evidence of space-time clustering based on place of birth and time of diagnosis, particularly for all leukaemias aged 0-14 and 0-4 years, and acute lymphoblastic leukaemia (ALL) 0-4 years. Some results based on location at diagnosis were significant but mainly gave larger P-values. The results are consistent with an infectious hypothesis. Furthermore, we found an excess of male cases over females involved in space-time pairs. We suggest this may be related to genetic differences in susceptibility to infection between males and females. These findings provide the basis for future studies to identify possible infectious agents.en
dc.language.isoenen
dc.subjectLeukaemiaen
dc.subject.meshAdolescent-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshCluster Analysis-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGreat Britain-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshInfection-
dc.subject.meshLeukemia-
dc.subject.meshMale-
dc.subject.meshSex Factors-
dc.titleSpace-time clustering patterns in childhood leukaemia support a role for infection.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric & Familial Cancer Research Group, Royal Manchester Children's Hospital, Stancliffe, UK.en
dc.identifier.journalBritish Journal of Canceren

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