Expression of CD11b/CD18 on neutrophils after consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous haematopoietic stem cell transplantation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/86190
Title:
Expression of CD11b/CD18 on neutrophils after consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous haematopoietic stem cell transplantation.
Authors:
Wang, X; Clowes, C; Duarte, R; Pu, Qingqiu
Abstract:
Quantitative expression of neutrophil CD11b/CD18 following chemotherapy (either conventional dose consolidation chemotherapy or high dose chemotherapy with autologous stem cell transplantation) was investigated during the early recovery phase (neutrophil count 0. 5-1.0x109/l) and at full recovery (neutrophil count 1.0-2.5x109/l) following treatment. CD11b/18 expression was normal in stem cell transplantation supported patients during both early and full neutrophil recovery. By contrast CD11b/CD18 expression was markedly decreased in patients who received chemotherapy without stem cell support. These results suggest that recovery of neutrophil count may not always coincide with recovery of neutrophil function and that G-CSF stimulated peripheral stem cell transplantation enhances neutrophil function post chemotherapy.
Affiliation:
School of Biological Science, The University of Manchester, UK.
Citation:
Expression of CD11b/CD18 on neutrophils after consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous haematopoietic stem cell transplantation. 2000, 17 (3):597-602 Int. J. Oncol.
Journal:
International Journal of Oncology
Issue Date:
Sep-2000
URI:
http://hdl.handle.net/10541/86190
PubMed ID:
10938404
Type:
Article
Language:
en
ISSN:
1019-6439
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWang, Xen
dc.contributor.authorClowes, Cen
dc.contributor.authorDuarte, Ren
dc.contributor.authorPu, Qingqiuen
dc.date.accessioned2009-11-13T15:48:47Z-
dc.date.available2009-11-13T15:48:47Z-
dc.date.issued2000-09-
dc.identifier.citationExpression of CD11b/CD18 on neutrophils after consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous haematopoietic stem cell transplantation. 2000, 17 (3):597-602 Int. J. Oncol.en
dc.identifier.issn1019-6439-
dc.identifier.pmid10938404-
dc.identifier.urihttp://hdl.handle.net/10541/86190-
dc.description.abstractQuantitative expression of neutrophil CD11b/CD18 following chemotherapy (either conventional dose consolidation chemotherapy or high dose chemotherapy with autologous stem cell transplantation) was investigated during the early recovery phase (neutrophil count 0. 5-1.0x109/l) and at full recovery (neutrophil count 1.0-2.5x109/l) following treatment. CD11b/18 expression was normal in stem cell transplantation supported patients during both early and full neutrophil recovery. By contrast CD11b/CD18 expression was markedly decreased in patients who received chemotherapy without stem cell support. These results suggest that recovery of neutrophil count may not always coincide with recovery of neutrophil function and that G-CSF stimulated peripheral stem cell transplantation enhances neutrophil function post chemotherapy.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectLeukaemic Gene Expresssion Regulationen
dc.subjectHaematopoietic Stem Cell Transplantationen
dc.subjectMyeloid Leukaemiaen
dc.subject.meshAcute Disease-
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAntigens, CD18-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshBiological Markers-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshCytarabine-
dc.subject.meshEtoposide-
dc.subject.meshFemale-
dc.subject.meshFilgrastim-
dc.subject.meshGene Expression Regulation, Leukemic-
dc.subject.meshHematopoietic Stem Cell Transplantation-
dc.subject.meshHumans-
dc.subject.meshLeukemia, Myeloid-
dc.subject.meshMacrophage-1 Antigen-
dc.subject.meshMale-
dc.subject.meshMelphalan-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshNeutropenia-
dc.subject.meshRemission Induction-
dc.titleExpression of CD11b/CD18 on neutrophils after consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous haematopoietic stem cell transplantation.en
dc.typeArticleen
dc.contributor.departmentSchool of Biological Science, The University of Manchester, UK.en
dc.identifier.journalInternational Journal of Oncologyen

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