2.50
Hdl Handle:
http://hdl.handle.net/10541/86147
Title:
Bcl-w expression in colorectal adenocarcinoma.
Authors:
Wilson, James W; Nostro, M C; Balzi, Manuela; Faraoni, P; Cianchi, F; Becciolini, Aldo; Potten, Christopher S
Abstract:
We have found that the anti-apoptotic Bcl-2 family protein, Bcl-w, was frequently expressed in colorectal adenocarcinomas, with 69/75 showing positive staining with anti-Bcl-w IgG. Adenomas demonstrated a much lower frequency of Bcl-w expression (only 1 of 17), as did adenocarcinomas from other epithelial tissues such as breast (0/8), stomach (1112) and cervix (0/12). Bcl-w status could be related to the histopathological classification of the tumours, with TNM stage III tumours showing significantly higher levels of expression than tumours of better prognostic grade (at P = 0.009). Those patients with node involvement also had tumours with significantly elevated levels of Bcl-w (at P = 0.02), compared to those which were node-negative. The results suggest that Bcl-w could play a general role in the progression from adenoma to adenocarcinoma in the colorectal epithelium. Currently, more data are being collected to allow us to assess the importance of Bcl-w for disease progression and patient survival.
Affiliation:
CRC Epithelial Biology Laboratory, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
Bcl-w expression in colorectal adenocarcinoma. 2000, 82 (1):178-85 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Jan-2000
URI:
http://hdl.handle.net/10541/86147
DOI:
10.1054/bjoc.1999.0897
PubMed ID:
10638987
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWilson, James Wen
dc.contributor.authorNostro, M Cen
dc.contributor.authorBalzi, Manuelaen
dc.contributor.authorFaraoni, Pen
dc.contributor.authorCianchi, Fen
dc.contributor.authorBecciolini, Aldoen
dc.contributor.authorPotten, Christopher Sen
dc.date.accessioned2009-11-13T15:28:41Z-
dc.date.available2009-11-13T15:28:41Z-
dc.date.issued2000-01-
dc.identifier.citationBcl-w expression in colorectal adenocarcinoma. 2000, 82 (1):178-85 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid10638987-
dc.identifier.doi10.1054/bjoc.1999.0897-
dc.identifier.urihttp://hdl.handle.net/10541/86147-
dc.description.abstractWe have found that the anti-apoptotic Bcl-2 family protein, Bcl-w, was frequently expressed in colorectal adenocarcinomas, with 69/75 showing positive staining with anti-Bcl-w IgG. Adenomas demonstrated a much lower frequency of Bcl-w expression (only 1 of 17), as did adenocarcinomas from other epithelial tissues such as breast (0/8), stomach (1112) and cervix (0/12). Bcl-w status could be related to the histopathological classification of the tumours, with TNM stage III tumours showing significantly higher levels of expression than tumours of better prognostic grade (at P = 0.009). Those patients with node involvement also had tumours with significantly elevated levels of Bcl-w (at P = 0.02), compared to those which were node-negative. The results suggest that Bcl-w could play a general role in the progression from adenoma to adenocarcinoma in the colorectal epithelium. Currently, more data are being collected to allow us to assess the importance of Bcl-w for disease progression and patient survival.en
dc.language.isoenen
dc.subjectColonic Canceren
dc.subjectCancer Proteinsen
dc.subjectRectal Canceren
dc.subjectTumour Suppressor Protein p53en
dc.subject.meshAdenocarcinoma-
dc.subject.meshAdenocarcinoma, Mucinous-
dc.subject.meshApoptosis Regulatory Proteins-
dc.subject.meshColonic Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIntestinal Mucosa-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshPloidies-
dc.subject.meshPrognosis-
dc.subject.meshProteins-
dc.subject.meshRectal Neoplasms-
dc.subject.meshSex Factors-
dc.subject.meshTumor Suppressor Protein p53-
dc.titleBcl-w expression in colorectal adenocarcinoma.en
dc.typeArticleen
dc.contributor.departmentCRC Epithelial Biology Laboratory, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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