Authors
Wilson, James WNostro, M C
Balzi, Manuela
Faraoni, P
Cianchi, F
Becciolini, Aldo
Potten, Christopher S
Affiliation
CRC Epithelial Biology Laboratory, Paterson Institute for Cancer Research, Manchester, UK.Issue Date
2000-01
Metadata
Show full item recordAbstract
We have found that the anti-apoptotic Bcl-2 family protein, Bcl-w, was frequently expressed in colorectal adenocarcinomas, with 69/75 showing positive staining with anti-Bcl-w IgG. Adenomas demonstrated a much lower frequency of Bcl-w expression (only 1 of 17), as did adenocarcinomas from other epithelial tissues such as breast (0/8), stomach (1112) and cervix (0/12). Bcl-w status could be related to the histopathological classification of the tumours, with TNM stage III tumours showing significantly higher levels of expression than tumours of better prognostic grade (at P = 0.009). Those patients with node involvement also had tumours with significantly elevated levels of Bcl-w (at P = 0.02), compared to those which were node-negative. The results suggest that Bcl-w could play a general role in the progression from adenoma to adenocarcinoma in the colorectal epithelium. Currently, more data are being collected to allow us to assess the importance of Bcl-w for disease progression and patient survival.Citation
Bcl-w expression in colorectal adenocarcinoma. 2000, 82 (1):178-85 Br. J. CancerJournal
British Journal of CancerDOI
10.1054/bjoc.1999.0897PubMed ID
10638987Type
ArticleLanguage
enISSN
0007-0920ae974a485f413a2113503eed53cd6c53
10.1054/bjoc.1999.0897